Local host response in the lower respiratory tract in nephropathia epidemica
(1993) In Scandinavian Journal of Infectious Diseases 25(5). p.639-646- Abstract
- Various lines of evidence suggest a respiratory route of transmission of nephropathia epidemica (NE). To study the response of the respiratory tract in NE, fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) was performed in 5 patients in the acute phase of the disease. Compared to a reference group of 15 healthy individuals, BAL fluid of NE patients contained significantly higher total numbers of cells (p < 0.05) and significantly higher numbers of lysozyme-positive macrophages (p < 0.01), CD8+ T cells (p < 0.01), and natural killer (NK) cells (p < 0.01). There was no significant difference in numbers of CD4+ T cells, B cells, or neutrophils. When blood samples of 16 patients were examined at various intervals after... (More)
- Various lines of evidence suggest a respiratory route of transmission of nephropathia epidemica (NE). To study the response of the respiratory tract in NE, fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) was performed in 5 patients in the acute phase of the disease. Compared to a reference group of 15 healthy individuals, BAL fluid of NE patients contained significantly higher total numbers of cells (p < 0.05) and significantly higher numbers of lysozyme-positive macrophages (p < 0.01), CD8+ T cells (p < 0.01), and natural killer (NK) cells (p < 0.01). There was no significant difference in numbers of CD4+ T cells, B cells, or neutrophils. When blood samples of 16 patients were examined at various intervals after onset of NE, a significant decrease in the number of NK cells (p < 0.01) was found in the acute phase of the disease. The findings are compatible with the presence of a local host response in the lower respiratory tract to NE virus infection. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1107087
- author
- Linderholm, Mats ; Bjermer, Leif LU ; Juto, Per ; Roos, Göran ; Sandstrom, Thomas ; Settergren, Bo and Tarnvik, Arne
- organization
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Infectious Diseases
- volume
- 25
- issue
- 5
- pages
- 639 - 646
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:7904380
- scopus:0027424836
- ISSN
- 1651-1980
- DOI
- 10.3109/00365549309008554
- language
- English
- LU publication?
- yes
- id
- d6afe053-cda9-44db-972d-206c16e20c58 (old id 1107087)
- date added to LUP
- 2016-04-01 16:55:59
- date last changed
- 2021-03-28 03:24:48
@article{d6afe053-cda9-44db-972d-206c16e20c58, abstract = {{Various lines of evidence suggest a respiratory route of transmission of nephropathia epidemica (NE). To study the response of the respiratory tract in NE, fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) was performed in 5 patients in the acute phase of the disease. Compared to a reference group of 15 healthy individuals, BAL fluid of NE patients contained significantly higher total numbers of cells (p < 0.05) and significantly higher numbers of lysozyme-positive macrophages (p < 0.01), CD8+ T cells (p < 0.01), and natural killer (NK) cells (p < 0.01). There was no significant difference in numbers of CD4+ T cells, B cells, or neutrophils. When blood samples of 16 patients were examined at various intervals after onset of NE, a significant decrease in the number of NK cells (p < 0.01) was found in the acute phase of the disease. The findings are compatible with the presence of a local host response in the lower respiratory tract to NE virus infection.}}, author = {{Linderholm, Mats and Bjermer, Leif and Juto, Per and Roos, Göran and Sandstrom, Thomas and Settergren, Bo and Tarnvik, Arne}}, issn = {{1651-1980}}, language = {{eng}}, number = {{5}}, pages = {{639--646}}, publisher = {{Informa Healthcare}}, series = {{Scandinavian Journal of Infectious Diseases}}, title = {{Local host response in the lower respiratory tract in nephropathia epidemica}}, url = {{http://dx.doi.org/10.3109/00365549309008554}}, doi = {{10.3109/00365549309008554}}, volume = {{25}}, year = {{1993}}, }