Nerve Regeneration In Nerve Grafts Conditioned By Vibration Exposure
Bergman, Stina ; Widerberg, Annika LU ; Danielsen, Nils LU ; Lundborg, Göran LU and Dahlin, Lars LU
(1995)
In Restorative Neurology and Neuroscience
7(3).
p.165-169
- Abstract
- Regeneration distances were studied in nerves from vibration-exposed limbs. One hind limb of anaesthetized rats was attached to a vibration exciter and exposed to vibration (80 Hz/32 m/s2) for 5 h/day for 2 or 5 days. Seven days after the latest period a 10-mm long nerve graft was taken from the vibrated sciatic nerve and sutured into a corresponding defect in the contralateral sciatic nerve and vice versa, thereby creating two different models within the same animal: (i) regeneration from a freshly transected unvibrated nerve into a vibrated graft and (ii) regeneration from a vibrated nerve into a fresh nerve graft (vibrated recipient side). Four, 6 or 8 days postoperatively (p.o.) the distances achieved by the regenerating axons were... (More)
- Regeneration distances were studied in nerves from vibration-exposed limbs. One hind limb of anaesthetized rats was attached to a vibration exciter and exposed to vibration (80 Hz/32 m/s2) for 5 h/day for 2 or 5 days. Seven days after the latest period a 10-mm long nerve graft was taken from the vibrated sciatic nerve and sutured into a corresponding defect in the contralateral sciatic nerve and vice versa, thereby creating two different models within the same animal: (i) regeneration from a freshly transected unvibrated nerve into a vibrated graft and (ii) regeneration from a vibrated nerve into a fresh nerve graft (vibrated recipient side). Four, 6 or 8 days postoperatively (p.o.) the distances achieved by the regenerating axons were determined using the pinch reflex test. Two days of vibration did not influence the regeneration, but 5 days of vibration reduced the initial delay period and a slight reduction of regeneration rate was observed. After 5 days of vibration an increased regeneration distance was observed in both models at day 4 p.o. and at day 6 p.o. in vibrated grafts. This study demonstrates that vibration can condition peripheral nerves and this may by caused by local changes in the peripheral nerve trunk and in the neuron itself. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1109654
- author
- Bergman, Stina
; Widerberg, Annika
LU
; Danielsen, Nils
LU
; Lundborg, Göran
LU
and Dahlin, Lars
LU
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Sciatic nerve, Lesion, Regeneration, Transplantation, Vibration, Schwann cell, Conditioning, Rat, Peripheral nerve, Peripheral nervous system, Rodentia, Mammalia, Vertebrata
- in
- Restorative Neurology and Neuroscience
- volume
- 7
- issue
- 3
- pages
- 165 - 169
- publisher
- IOS Press
- external identifiers
-
- scopus:0028916996
- pmid:21551785
- ISSN
- 1878-3627
- DOI
- 10.3233/RNN-1994-7306
- language
- English
- LU publication?
- no
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hand Surgery Research Group (013241910), Reconstructive Surgery (013240300)
- id
- bd7c5db1-d6a3-436d-b216-ca54675b82a9 (old id 1109654)
- date added to LUP
- 2016-04-01 17:02:34
- date last changed
- 2021-01-03 10:04:48
@article{bd7c5db1-d6a3-436d-b216-ca54675b82a9,
abstract = {{Regeneration distances were studied in nerves from vibration-exposed limbs. One hind limb of anaesthetized rats was attached to a vibration exciter and exposed to vibration (80 Hz/32 m/s2) for 5 h/day for 2 or 5 days. Seven days after the latest period a 10-mm long nerve graft was taken from the vibrated sciatic nerve and sutured into a corresponding defect in the contralateral sciatic nerve and vice versa, thereby creating two different models within the same animal: (i) regeneration from a freshly transected unvibrated nerve into a vibrated graft and (ii) regeneration from a vibrated nerve into a fresh nerve graft (vibrated recipient side). Four, 6 or 8 days postoperatively (p.o.) the distances achieved by the regenerating axons were determined using the pinch reflex test. Two days of vibration did not influence the regeneration, but 5 days of vibration reduced the initial delay period and a slight reduction of regeneration rate was observed. After 5 days of vibration an increased regeneration distance was observed in both models at day 4 p.o. and at day 6 p.o. in vibrated grafts. This study demonstrates that vibration can condition peripheral nerves and this may by caused by local changes in the peripheral nerve trunk and in the neuron itself.}},
author = {{Bergman, Stina and Widerberg, Annika and Danielsen, Nils and Lundborg, Göran and Dahlin, Lars}},
issn = {{1878-3627}},
keywords = {{Sciatic nerve; Lesion; Regeneration; Transplantation; Vibration; Schwann cell; Conditioning; Rat; Peripheral nerve; Peripheral nervous system; Rodentia; Mammalia; Vertebrata}},
language = {{eng}},
number = {{3}},
pages = {{165--169}},
publisher = {{IOS Press}},
series = {{Restorative Neurology and Neuroscience}},
title = {{Nerve Regeneration In Nerve Grafts Conditioned By Vibration Exposure}},
url = {{http://dx.doi.org/10.3233/RNN-1994-7306}},
doi = {{10.3233/RNN-1994-7306}},
volume = {{7}},
year = {{1995}},
}