Restitution of neurophysiological functions, performance, and subjective symptoms after moderate insulin-induced hypoglycaemia in non-diabetic men
(1996) In Diabetic Medicine 13(3). p.218-225- Abstract
- The restoration of cognitive function was studied in 10 healthy men aged 26 years (25.5 +/- 1.2 years; mean +/- SD) after insulin-induced hypoglycaemia (arterialized blood glucose 2.5 +/- 0.4 mmol l-1) for 62 +/- 8 min. Another group of six men participated in a single blind sham study for comparison. The hypoglycaemic event caused a significant increase (p = 0.006) in serum adrenaline levels. Ratings of adrenergically mediated symptoms increased during hypoglycaemia (p = 0.006), as did neuroglycopenic symptoms (p = 0.002), although neuroglycopenia ratings increased in both studies. During hypoglycaemia, P300 amplitudes in a relatively demanding visual search task decreased (p = 0.02), whereas easier tasks were unaffected. The amplitudes... (More)
- The restoration of cognitive function was studied in 10 healthy men aged 26 years (25.5 +/- 1.2 years; mean +/- SD) after insulin-induced hypoglycaemia (arterialized blood glucose 2.5 +/- 0.4 mmol l-1) for 62 +/- 8 min. Another group of six men participated in a single blind sham study for comparison. The hypoglycaemic event caused a significant increase (p = 0.006) in serum adrenaline levels. Ratings of adrenergically mediated symptoms increased during hypoglycaemia (p = 0.006), as did neuroglycopenic symptoms (p = 0.002), although neuroglycopenia ratings increased in both studies. During hypoglycaemia, P300 amplitudes in a relatively demanding visual search task decreased (p = 0.02), whereas easier tasks were unaffected. The amplitudes were restored after 40 min of normoglycaemia. Reaction time deteriorated after restoration of normoglycaemia, suggesting an effect of hypoglycaemia on learning. Thus, hypoglycaemia at a blood glucose level that is common among patients treated with insulin causes clear cognitive dysfunction, although restoration of the cognitive dysfunction to normal was fast. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1110229
- author
- Lindgren, M ; Eckert, B ; Stenberg, Georg LU and Agardh, Carl-David LU
- organization
- publishing date
- 1996
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Hypoglycaemia Cognitive Function
- in
- Diabetic Medicine
- volume
- 13
- issue
- 3
- pages
- 218 - 225
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:8689841
- scopus:0029926688
- ISSN
- 1464-5491
- DOI
- 10.1002/(SICI)1096-9136(199603)13:3<218::AID-DIA25>3.0.CO;2-D
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit on Vascular Diabetic Complications (013241510), Clinical Neurophysiology (013013001)
- id
- 518f2bf6-f092-4818-80c1-ba0e77253cfa (old id 1110229)
- date added to LUP
- 2016-04-01 15:49:51
- date last changed
- 2022-01-28 07:22:26
@article{518f2bf6-f092-4818-80c1-ba0e77253cfa, abstract = {{The restoration of cognitive function was studied in 10 healthy men aged 26 years (25.5 +/- 1.2 years; mean +/- SD) after insulin-induced hypoglycaemia (arterialized blood glucose 2.5 +/- 0.4 mmol l-1) for 62 +/- 8 min. Another group of six men participated in a single blind sham study for comparison. The hypoglycaemic event caused a significant increase (p = 0.006) in serum adrenaline levels. Ratings of adrenergically mediated symptoms increased during hypoglycaemia (p = 0.006), as did neuroglycopenic symptoms (p = 0.002), although neuroglycopenia ratings increased in both studies. During hypoglycaemia, P300 amplitudes in a relatively demanding visual search task decreased (p = 0.02), whereas easier tasks were unaffected. The amplitudes were restored after 40 min of normoglycaemia. Reaction time deteriorated after restoration of normoglycaemia, suggesting an effect of hypoglycaemia on learning. Thus, hypoglycaemia at a blood glucose level that is common among patients treated with insulin causes clear cognitive dysfunction, although restoration of the cognitive dysfunction to normal was fast.}}, author = {{Lindgren, M and Eckert, B and Stenberg, Georg and Agardh, Carl-David}}, issn = {{1464-5491}}, keywords = {{Hypoglycaemia Cognitive Function}}, language = {{eng}}, number = {{3}}, pages = {{218--225}}, publisher = {{Wiley-Blackwell}}, series = {{Diabetic Medicine}}, title = {{Restitution of neurophysiological functions, performance, and subjective symptoms after moderate insulin-induced hypoglycaemia in non-diabetic men}}, url = {{http://dx.doi.org/10.1002/(SICI)1096-9136(199603)13:3<218::AID-DIA25>3.0.CO;2-D}}, doi = {{10.1002/(SICI)1096-9136(199603)13:3<218::AID-DIA25>3.0.CO;2-D}}, volume = {{13}}, year = {{1996}}, }