The importance of cofactors in the histologic progression of minimal and mild chronic hepatitis C
(1997) In Liver 17(5). p.215-223- Abstract
- A follow-up liver biopsy was done 9-16 years (mean 12 years) after initial biopsy in 20 untreated Swedish patients infected with hepatitis C (8 men, 12 women; mean age 30 years at initial biopsy) in whom first biopsy had been classified as chronic persistent hepatitis. A significant progression of liver damage was found when using Histology Activity Index (HAI) scoring according to Knodell (p=0.006 for total HAI score; p=0.03 for grading, i.e., sum of HAI components 1, 2, and 3; p=0.01 for staging, i.e., HAI component 4, fibrosis). Fourteen of 20 (70%) patients had increased while 6 had decreased or unchanged HAI scores on follow-up biopsy. Occasional heavy alcohol drinkers (n=6) had an increased follow-up HAI score as compared with... (More)
- A follow-up liver biopsy was done 9-16 years (mean 12 years) after initial biopsy in 20 untreated Swedish patients infected with hepatitis C (8 men, 12 women; mean age 30 years at initial biopsy) in whom first biopsy had been classified as chronic persistent hepatitis. A significant progression of liver damage was found when using Histology Activity Index (HAI) scoring according to Knodell (p=0.006 for total HAI score; p=0.03 for grading, i.e., sum of HAI components 1, 2, and 3; p=0.01 for staging, i.e., HAI component 4, fibrosis). Fourteen of 20 (70%) patients had increased while 6 had decreased or unchanged HAI scores on follow-up biopsy. Occasional heavy alcohol drinkers (n=6) had an increased follow-up HAI score as compared with nondrinkers (p<0.05). Eight of 14 who deteriorated on follow-up versus 0 of 6 with improved or unchanged liver histology were anti-HBc positive (p=0.04). There was no significant correlation between HCV genotype and prognosis; however, the only two patients with liver cirrhosis on follow-up had genotype 1b. In conclusion, most patients with minimal or mild chronic hepatitis C in the present study had histologic progression on the latest biopsy. Cofactors such as alcohol abuse and exposure to hepatitis B may have a greater influence than HCV alone in determining the rate of deterioration of liver disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1111259
- author
- Shev, S ; Dhillon, A P ; Lindh, M ; Serleus, Z ; Wejstal, R ; Widell, Anders LU and Norkrans, G
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Liver
- volume
- 17
- issue
- 5
- pages
- 215 - 223
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:9387912
- scopus:0030671209
- ISSN
- 0106-9543
- language
- English
- LU publication?
- yes
- id
- a5d89ace-ab58-434b-b3cc-ec3d71e94855 (old id 1111259)
- date added to LUP
- 2016-04-01 12:00:32
- date last changed
- 2022-03-28 18:55:53
@article{a5d89ace-ab58-434b-b3cc-ec3d71e94855, abstract = {{A follow-up liver biopsy was done 9-16 years (mean 12 years) after initial biopsy in 20 untreated Swedish patients infected with hepatitis C (8 men, 12 women; mean age 30 years at initial biopsy) in whom first biopsy had been classified as chronic persistent hepatitis. A significant progression of liver damage was found when using Histology Activity Index (HAI) scoring according to Knodell (p=0.006 for total HAI score; p=0.03 for grading, i.e., sum of HAI components 1, 2, and 3; p=0.01 for staging, i.e., HAI component 4, fibrosis). Fourteen of 20 (70%) patients had increased while 6 had decreased or unchanged HAI scores on follow-up biopsy. Occasional heavy alcohol drinkers (n=6) had an increased follow-up HAI score as compared with nondrinkers (p<0.05). Eight of 14 who deteriorated on follow-up versus 0 of 6 with improved or unchanged liver histology were anti-HBc positive (p=0.04). There was no significant correlation between HCV genotype and prognosis; however, the only two patients with liver cirrhosis on follow-up had genotype 1b. In conclusion, most patients with minimal or mild chronic hepatitis C in the present study had histologic progression on the latest biopsy. Cofactors such as alcohol abuse and exposure to hepatitis B may have a greater influence than HCV alone in determining the rate of deterioration of liver disease.}}, author = {{Shev, S and Dhillon, A P and Lindh, M and Serleus, Z and Wejstal, R and Widell, Anders and Norkrans, G}}, issn = {{0106-9543}}, language = {{eng}}, number = {{5}}, pages = {{215--223}}, publisher = {{Wiley-Blackwell}}, series = {{Liver}}, title = {{The importance of cofactors in the histologic progression of minimal and mild chronic hepatitis C}}, volume = {{17}}, year = {{1997}}, }