Major metabolic pathway for N-methyl-2-pyrrolidone in humans
(1997) In Drug Metabolism and Disposition 25(2). p.267-269- Abstract
- The aim was to study the metabolic pathway for N-methyl-2-pyrrolidone (NMP) in humans. Three healthy male volunteers were administered 100 mg NMP orally. All urine was collected during nine consecutive days. The identification and quantification of the metabolites were performed by gas chromatography/mass spectrometry (GC/MS). NMP, 5-hydroxy-N-methyl-2-pyrrolidone (5-HNMP), N-methylsuccinimide (MSI), and 2-hydroxy-N-methylsuccinimide (2-HMSI) were found in urine. The mean excreted fractions for NMP, 5-HNMP, MSI, and 2-HMSI were 0.8%, 44%, 0.4%, and 20%, respectively. There was no conjugation with glucoronic acid or sulfate or either 5-HNMP or 2-HMSI. One-third of the orally dosed NMP was not recovered in urine as either NMP, 5-HNMP, MSI,... (More)
- The aim was to study the metabolic pathway for N-methyl-2-pyrrolidone (NMP) in humans. Three healthy male volunteers were administered 100 mg NMP orally. All urine was collected during nine consecutive days. The identification and quantification of the metabolites were performed by gas chromatography/mass spectrometry (GC/MS). NMP, 5-hydroxy-N-methyl-2-pyrrolidone (5-HNMP), N-methylsuccinimide (MSI), and 2-hydroxy-N-methylsuccinimide (2-HMSI) were found in urine. The mean excreted fractions for NMP, 5-HNMP, MSI, and 2-HMSI were 0.8%, 44%, 0.4%, and 20%, respectively. There was no conjugation with glucoronic acid or sulfate or either 5-HNMP or 2-HMSI. One-third of the orally dosed NMP was not recovered in urine as either NMP, 5-HNMP, MSI, or 2-HMSI. The half-lives for 5-HNMP, MSI, and 2-HMSI in urine were approximately 4, 8, and 17 hr, respectively. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1111499
- author
- Åkesson, Bengt LU and Jönsson, Bo A LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Drug Metabolism and Disposition
- volume
- 25
- issue
- 2
- pages
- 267 - 269
- publisher
- American Society for Pharmacology and Experimental Therapeutics
- external identifiers
-
- pmid:9029058
- scopus:0342275194
- ISSN
- 1521-009X
- language
- English
- LU publication?
- yes
- id
- 7c5cc1b4-953f-4d4d-9b0c-8318e943f362 (old id 1111499)
- alternative location
- http://dmd.aspetjournals.org/cgi/content/full/25/2/267
- date added to LUP
- 2016-04-01 12:10:57
- date last changed
- 2022-03-28 21:23:57
@article{7c5cc1b4-953f-4d4d-9b0c-8318e943f362, abstract = {{The aim was to study the metabolic pathway for N-methyl-2-pyrrolidone (NMP) in humans. Three healthy male volunteers were administered 100 mg NMP orally. All urine was collected during nine consecutive days. The identification and quantification of the metabolites were performed by gas chromatography/mass spectrometry (GC/MS). NMP, 5-hydroxy-N-methyl-2-pyrrolidone (5-HNMP), N-methylsuccinimide (MSI), and 2-hydroxy-N-methylsuccinimide (2-HMSI) were found in urine. The mean excreted fractions for NMP, 5-HNMP, MSI, and 2-HMSI were 0.8%, 44%, 0.4%, and 20%, respectively. There was no conjugation with glucoronic acid or sulfate or either 5-HNMP or 2-HMSI. One-third of the orally dosed NMP was not recovered in urine as either NMP, 5-HNMP, MSI, or 2-HMSI. The half-lives for 5-HNMP, MSI, and 2-HMSI in urine were approximately 4, 8, and 17 hr, respectively.}}, author = {{Åkesson, Bengt and Jönsson, Bo A}}, issn = {{1521-009X}}, language = {{eng}}, number = {{2}}, pages = {{267--269}}, publisher = {{American Society for Pharmacology and Experimental Therapeutics}}, series = {{Drug Metabolism and Disposition}}, title = {{Major metabolic pathway for N-methyl-2-pyrrolidone in humans}}, url = {{http://dmd.aspetjournals.org/cgi/content/full/25/2/267}}, volume = {{25}}, year = {{1997}}, }