Altered endothelial/pericyte ratio in Goto-Kakizaki rat retina
(1997) In Journal of Diabetes and its Complications 11(3). p.158-162- Abstract
- The Goto-Kakizaki (GK) rat represents a model of hereditary non-insulin-dependent diabetes mellitus (NIDDM), characterized by nonobesity, mild hyperglycemia from early life, impaired glucose tolerance test results, and a markedly defective insulin response to glucose. The rats develop signs of both nephropathy and neuropathy, but, to our knowledge, retinal changes have not been reported so far in this model of NIDDM. Hence, the aim of the present study was to assess whether morphological vascular changes could be demonstrated in retinal vessel preparations of GK rats. The endothelial/pericyte ratio was found to be higher in GK rats aged 8 months as well as after 24-30 months compared to their matched controls (2.3 +/- 0.2 versus 2.0 +/-... (More)
- The Goto-Kakizaki (GK) rat represents a model of hereditary non-insulin-dependent diabetes mellitus (NIDDM), characterized by nonobesity, mild hyperglycemia from early life, impaired glucose tolerance test results, and a markedly defective insulin response to glucose. The rats develop signs of both nephropathy and neuropathy, but, to our knowledge, retinal changes have not been reported so far in this model of NIDDM. Hence, the aim of the present study was to assess whether morphological vascular changes could be demonstrated in retinal vessel preparations of GK rats. The endothelial/pericyte ratio was found to be higher in GK rats aged 8 months as well as after 24-30 months compared to their matched controls (2.3 +/- 0.2 versus 2.0 +/- 0.1; p < 0.01, and 2.6 +/- 0.2 versus 1.9 +/- 0.1; p < 0.001, respectively). Furthermore, in 24 to 30-months-old GK rats, the endothelial/pericyte ratio was higher than in 8 month old GK rats (p < 0.05). Thus, the GK rat appears to be a suitable model for experimental studies of chronic complications, including diabetic retinopathy, in NIDDM. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1111705
- author
- Agardh, Carl-David LU ; Agardh, Elisabet LU ; Zhang, Hui and Östenson, Claes-Göran
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Diabetes and its Complications
- volume
- 11
- issue
- 3
- pages
- 158 - 162
- publisher
- Elsevier
- external identifiers
-
- pmid:9174896
- scopus:0031006055
- ISSN
- 1873-460X
- DOI
- 10.1016/S1056-8727(96)00049-9
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit on Vascular Diabetic Complications (013241510)
- id
- a624509e-9d10-4501-b0a4-f644a9a49a55 (old id 1111705)
- date added to LUP
- 2016-04-01 17:06:28
- date last changed
- 2022-01-29 00:23:03
@article{a624509e-9d10-4501-b0a4-f644a9a49a55, abstract = {{The Goto-Kakizaki (GK) rat represents a model of hereditary non-insulin-dependent diabetes mellitus (NIDDM), characterized by nonobesity, mild hyperglycemia from early life, impaired glucose tolerance test results, and a markedly defective insulin response to glucose. The rats develop signs of both nephropathy and neuropathy, but, to our knowledge, retinal changes have not been reported so far in this model of NIDDM. Hence, the aim of the present study was to assess whether morphological vascular changes could be demonstrated in retinal vessel preparations of GK rats. The endothelial/pericyte ratio was found to be higher in GK rats aged 8 months as well as after 24-30 months compared to their matched controls (2.3 +/- 0.2 versus 2.0 +/- 0.1; p < 0.01, and 2.6 +/- 0.2 versus 1.9 +/- 0.1; p < 0.001, respectively). Furthermore, in 24 to 30-months-old GK rats, the endothelial/pericyte ratio was higher than in 8 month old GK rats (p < 0.05). Thus, the GK rat appears to be a suitable model for experimental studies of chronic complications, including diabetic retinopathy, in NIDDM.}}, author = {{Agardh, Carl-David and Agardh, Elisabet and Zhang, Hui and Östenson, Claes-Göran}}, issn = {{1873-460X}}, language = {{eng}}, number = {{3}}, pages = {{158--162}}, publisher = {{Elsevier}}, series = {{Journal of Diabetes and its Complications}}, title = {{Altered endothelial/pericyte ratio in Goto-Kakizaki rat retina}}, url = {{http://dx.doi.org/10.1016/S1056-8727(96)00049-9}}, doi = {{10.1016/S1056-8727(96)00049-9}}, volume = {{11}}, year = {{1997}}, }