Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets
(1998) In Journal of Applied Physiology 84(4). p.1208-1216- Abstract
- We tested the hypothesis that controlled hypoxemic resuscitation improves early cerebral metabolic and electrophysiological recovery in hypoxic newborn piglets. Severely hypoxic anesthetized piglets were randomly divided into three resuscitation groups: hypoxemic, 21% O2, and 100% O2 groups (8 in each group). The hypoxemic group was mechanically ventilated with 12-18% O2 adjusted to achieve a cerebral venous O2 saturation of 17-23% (baseline; 45 +/- 1%). Base excess (BE) reached -22 +/- 1 mM at the end of hypoxia. During a 2-h resuscitation period, no significant differences in time to recovery of electroencephalography (EEG), quality of EEG at recovery, or extracellular hypoxanthine concentrations in the cerebral cortex and striatum were... (More)
- We tested the hypothesis that controlled hypoxemic resuscitation improves early cerebral metabolic and electrophysiological recovery in hypoxic newborn piglets. Severely hypoxic anesthetized piglets were randomly divided into three resuscitation groups: hypoxemic, 21% O2, and 100% O2 groups (8 in each group). The hypoxemic group was mechanically ventilated with 12-18% O2 adjusted to achieve a cerebral venous O2 saturation of 17-23% (baseline; 45 +/- 1%). Base excess (BE) reached -22 +/- 1 mM at the end of hypoxia. During a 2-h resuscitation period, no significant differences in time to recovery of electroencephalography (EEG), quality of EEG at recovery, or extracellular hypoxanthine concentrations in the cerebral cortex and striatum were found among the groups. BE and plasma hypoxanthine, however, normalized significantly more slowly during controlled hypoxemic resuscitation than during resuscitation with 21 or 100% O2. We conclude that early brain recovery during controlled hypoxemic resuscitation was as efficient as, but not superior to, recovery during resuscitation with 21 or 100% O2. The systemic metabolic recovery from hypoxia, however, was delayed during controlled hypoxemic resuscitation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1112715
- author
- Feet, B A ; Brun, N C ; Hellström-Westas, Lena LU ; Svenningsen, Niels W ; Greisen, G and Saugstad, O D
- organization
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- asphyxia, electroencephalography, near-infrared spectrophotometry, hypoxanthine, newborn piglets
- in
- Journal of Applied Physiology
- volume
- 84
- issue
- 4
- pages
- 1208 - 1216
- publisher
- American Physiological Society
- external identifiers
-
- pmid:9516186
- scopus:0031898449
- ISSN
- 1522-1601
- language
- English
- LU publication?
- yes
- id
- 3e37c679-9f85-4aae-b10e-c260a8b121af (old id 1112715)
- alternative location
- http://jap.physiology.org/cgi/content/full/84/4/1208
- date added to LUP
- 2016-04-01 12:35:57
- date last changed
- 2022-01-27 07:17:21
@article{3e37c679-9f85-4aae-b10e-c260a8b121af,
abstract = {{We tested the hypothesis that controlled hypoxemic resuscitation improves early cerebral metabolic and electrophysiological recovery in hypoxic newborn piglets. Severely hypoxic anesthetized piglets were randomly divided into three resuscitation groups: hypoxemic, 21% O2, and 100% O2 groups (8 in each group). The hypoxemic group was mechanically ventilated with 12-18% O2 adjusted to achieve a cerebral venous O2 saturation of 17-23% (baseline; 45 +/- 1%). Base excess (BE) reached -22 +/- 1 mM at the end of hypoxia. During a 2-h resuscitation period, no significant differences in time to recovery of electroencephalography (EEG), quality of EEG at recovery, or extracellular hypoxanthine concentrations in the cerebral cortex and striatum were found among the groups. BE and plasma hypoxanthine, however, normalized significantly more slowly during controlled hypoxemic resuscitation than during resuscitation with 21 or 100% O2. We conclude that early brain recovery during controlled hypoxemic resuscitation was as efficient as, but not superior to, recovery during resuscitation with 21 or 100% O2. The systemic metabolic recovery from hypoxia, however, was delayed during controlled hypoxemic resuscitation.}},
author = {{Feet, B A and Brun, N C and Hellström-Westas, Lena and Svenningsen, Niels W and Greisen, G and Saugstad, O D}},
issn = {{1522-1601}},
keywords = {{asphyxia; electroencephalography; near-infrared spectrophotometry; hypoxanthine; newborn piglets}},
language = {{eng}},
number = {{4}},
pages = {{1208--1216}},
publisher = {{American Physiological Society}},
series = {{Journal of Applied Physiology}},
title = {{Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets}},
url = {{http://jap.physiology.org/cgi/content/full/84/4/1208}},
volume = {{84}},
year = {{1998}},
}