Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults
Vinge, Ellen LU ; Lindergård, Birger LU ; Nilsson-Ehle, Peter LU and Grubb, Anders LU
(1999)
In Scandinavian Journal of Clinical & Laboratory Investigation
59(8).
p.587-592
- Abstract
- In an effort to increase our knowledge of the optimal use of serum cystatin C and creatinine as glomerular filtration rate (GFR) markers, these variables, as well as lean tissue mass and GFR, were determined in a population of 42 healthy young adults (men and women with normal GFR). Dual-energy X-ray absorptiometry and measurement of the plasma clearance of iohexol were used to measure lean tissue mass and GFR, respectively. Serum creatinine was significantly correlated to lean tissue mass (r=0.65; p < 0.0001) but not to GFR (1/creatinine vs. GFR: r=0.11; p=0.106). In contrast, serum cystatin C correlated with GFR (1/cystatin C vs. GFR: r=0.32; p=0.0387), especially in men (1/cystatin C vs. GFR: r=0.64; p=0.0055), but not to lean tissue... (More)
- In an effort to increase our knowledge of the optimal use of serum cystatin C and creatinine as glomerular filtration rate (GFR) markers, these variables, as well as lean tissue mass and GFR, were determined in a population of 42 healthy young adults (men and women with normal GFR). Dual-energy X-ray absorptiometry and measurement of the plasma clearance of iohexol were used to measure lean tissue mass and GFR, respectively. Serum creatinine was significantly correlated to lean tissue mass (r=0.65; p < 0.0001) but not to GFR (1/creatinine vs. GFR: r=0.11; p=0.106). In contrast, serum cystatin C correlated with GFR (1/cystatin C vs. GFR: r=0.32; p=0.0387), especially in men (1/cystatin C vs. GFR: r=0.64; p=0.0055), but not to lean tissue mass. These results might explain previous observations that serum cystatin C seems to be a better marker for GFR than serum creatinine, particularly for individuals with small to moderate decreases in GFR. However, the results also show that the serum concentrations of both creatinine and cystatin C are determined not only by GFR, but also by other factors. Since these additional factors differ for cystatin C and creatinine, it seems justified to use serum creatinine and cystatin C in conjunction to estimate GFR, at least until it is known in what situations serum creatinine or cystatin C is the preferable marker. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1115505
- author
- Vinge, Ellen
LU
; Lindergård, Birger
LU
; Nilsson-Ehle, Peter
LU
and Grubb, Anders
LU
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Sex characteristics
- in
- Scandinavian Journal of Clinical & Laboratory Investigation
- volume
- 59
- issue
- 8
- pages
- 587 - 592
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:10691049
- scopus:0033367864
- ISSN
- 1502-7686
- DOI
- 10.1080/00365519950185076
- language
- English
- LU publication?
- yes
- id
- 672e3a75-c02f-44e1-948e-72acd3b10206 (old id 1115505)
- date added to LUP
- 2016-04-01 16:27:23
- date last changed
- 2023-01-04 23:56:08
@article{672e3a75-c02f-44e1-948e-72acd3b10206,
abstract = {{In an effort to increase our knowledge of the optimal use of serum cystatin C and creatinine as glomerular filtration rate (GFR) markers, these variables, as well as lean tissue mass and GFR, were determined in a population of 42 healthy young adults (men and women with normal GFR). Dual-energy X-ray absorptiometry and measurement of the plasma clearance of iohexol were used to measure lean tissue mass and GFR, respectively. Serum creatinine was significantly correlated to lean tissue mass (r=0.65; p < 0.0001) but not to GFR (1/creatinine vs. GFR: r=0.11; p=0.106). In contrast, serum cystatin C correlated with GFR (1/cystatin C vs. GFR: r=0.32; p=0.0387), especially in men (1/cystatin C vs. GFR: r=0.64; p=0.0055), but not to lean tissue mass. These results might explain previous observations that serum cystatin C seems to be a better marker for GFR than serum creatinine, particularly for individuals with small to moderate decreases in GFR. However, the results also show that the serum concentrations of both creatinine and cystatin C are determined not only by GFR, but also by other factors. Since these additional factors differ for cystatin C and creatinine, it seems justified to use serum creatinine and cystatin C in conjunction to estimate GFR, at least until it is known in what situations serum creatinine or cystatin C is the preferable marker.}},
author = {{Vinge, Ellen and Lindergård, Birger and Nilsson-Ehle, Peter and Grubb, Anders}},
issn = {{1502-7686}},
keywords = {{Sex characteristics}},
language = {{eng}},
number = {{8}},
pages = {{587--592}},
publisher = {{Informa Healthcare}},
series = {{Scandinavian Journal of Clinical & Laboratory Investigation}},
title = {{Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults}},
url = {{http://dx.doi.org/10.1080/00365519950185076}},
doi = {{10.1080/00365519950185076}},
volume = {{59}},
year = {{1999}},
}