Neurturin enhances the survival of intrastriatal fetal dopaminergic transplants
Rosenblad, Carl ; Kirik, Deniz LU and Björklund, Anders LU
(1999)
In NeuroReport
10(8).
p.1783-1887
- Abstract
- We investigated here the effect of the novel glial cell line-derived neurotrophic factor (GDNF)-family member neurturin (NTN) on transplanted fetal dopamine (DA) neurons. Three groups of rats with complete unilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal DA system received intrastriatal grafts of embryonic ventral mesencephalic tissue. Following transplantation animals received repeated injections of vehicle or NTN (0.3 microg or 3.0 microg) over three weeks posttransplantation. NTN-treated animals had significantly (1.8-fold) more tyrosine hydroxylase-immunoreactive (TH-IR) neurons. Graft volume, TH-IR cell volume and overall dopaminergic host reinnervation remained unchanged. Amphetamine-induced rotation was rapidly... (More)
- We investigated here the effect of the novel glial cell line-derived neurotrophic factor (GDNF)-family member neurturin (NTN) on transplanted fetal dopamine (DA) neurons. Three groups of rats with complete unilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal DA system received intrastriatal grafts of embryonic ventral mesencephalic tissue. Following transplantation animals received repeated injections of vehicle or NTN (0.3 microg or 3.0 microg) over three weeks posttransplantation. NTN-treated animals had significantly (1.8-fold) more tyrosine hydroxylase-immunoreactive (TH-IR) neurons. Graft volume, TH-IR cell volume and overall dopaminergic host reinnervation remained unchanged. Amphetamine-induced rotation was rapidly compensated in all grafted rats. We conclude that administration of NTN may be a powerful way to increase survival of transplanted fetal DA neurons. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1115889
- author
- Rosenblad, Carl
; Kirik, Deniz
LU
and Björklund, Anders
LU
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- in
- NeuroReport
- volume
- 10
- issue
- 8
- pages
- 1783 - 1887
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:10501575
- scopus:0033519586
- ISSN
- 1473-558X
- language
- English
- LU publication?
- yes
- id
- 803efa1d-2654-4817-9d45-86e33874585c (old id 1115889)
- date added to LUP
- 2016-04-01 12:20:39
- date last changed
- 2022-01-27 02:18:53
@article{803efa1d-2654-4817-9d45-86e33874585c,
abstract = {{We investigated here the effect of the novel glial cell line-derived neurotrophic factor (GDNF)-family member neurturin (NTN) on transplanted fetal dopamine (DA) neurons. Three groups of rats with complete unilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal DA system received intrastriatal grafts of embryonic ventral mesencephalic tissue. Following transplantation animals received repeated injections of vehicle or NTN (0.3 microg or 3.0 microg) over three weeks posttransplantation. NTN-treated animals had significantly (1.8-fold) more tyrosine hydroxylase-immunoreactive (TH-IR) neurons. Graft volume, TH-IR cell volume and overall dopaminergic host reinnervation remained unchanged. Amphetamine-induced rotation was rapidly compensated in all grafted rats. We conclude that administration of NTN may be a powerful way to increase survival of transplanted fetal DA neurons.}},
author = {{Rosenblad, Carl and Kirik, Deniz and Björklund, Anders}},
issn = {{1473-558X}},
language = {{eng}},
number = {{8}},
pages = {{1783--1887}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{NeuroReport}},
title = {{Neurturin enhances the survival of intrastriatal fetal dopaminergic transplants}},
volume = {{10}},
year = {{1999}},
}