Prognostic implications of cytogenetic aberrations in diffuse large B-cell lymphomas
Jerkeman, Mats LU ; Johansson, Bertil LU ; Åkerman, Måns LU ; Cavallin-Ståhl, Eva LU ; Kristoffersson, Ulf LU and Mitelman, Felix LU
(1999)
In European Journal of Haematology
62(3).
p.184-190
- Abstract
- A single institution series of 81 consecutive, cytogenetically analyzed, diffuse large B-cell lymphomas (DLBL), the majority of which treated with anthracycline-containing combination chemotherapy, were reviewed retrospectively to investigate whether the karyotypic pattern or certain abnormalities correlate with survival. Clonal chromosome changes were found in 79 of the 81 cases. The prognostic impact of the following aberrations, all suggested in previous studies to be associated with either shorter or longer survival, were tested: 1q21-23 breakpoints, +2/dup(2p), +3/dup(3p), +5, +6, 6q21-25 breakpoints, monosomy 7/der(7p)/i(7q), trisomy 7, 14q11-12 breakpoints, monosomy 17/der(17p)/i(17q), trisomy 18, > 4 marker chromosomes, > 4... (More)
- A single institution series of 81 consecutive, cytogenetically analyzed, diffuse large B-cell lymphomas (DLBL), the majority of which treated with anthracycline-containing combination chemotherapy, were reviewed retrospectively to investigate whether the karyotypic pattern or certain abnormalities correlate with survival. Clonal chromosome changes were found in 79 of the 81 cases. The prognostic impact of the following aberrations, all suggested in previous studies to be associated with either shorter or longer survival, were tested: 1q21-23 breakpoints, +2/dup(2p), +3/dup(3p), +5, +6, 6q21-25 breakpoints, monosomy 7/der(7p)/i(7q), trisomy 7, 14q11-12 breakpoints, monosomy 17/der(17p)/i(17q), trisomy 18, > 4 marker chromosomes, > 4 breakpoints, and > or = 10 abnormalities. Univariate analysis showed that a breakpoint at 1q21-23 or trisomy 6 was associated with a shorter survival. However, when adjusted for age, stage, performance status and lactate dehydrogenase level, none of the cytogenetic aberrations had an independent prognostic value. Thus, the present investigation provides no support for any of the above-mentioned abnormalities being of prognostic importance in DLBL. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1116066
- author
- Jerkeman, Mats
LU
; Johansson, Bertil
LU
; Åkerman, Måns
LU
; Cavallin-Ståhl, Eva
LU
; Kristoffersson, Ulf
LU
and Mitelman, Felix
LU
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- B-Lymphocyte, Large cell lymphoma, Chromosomal aberration, Cytogenetics, Prognosis, Human, Non Hodgkin lymphoma, Lymphoproliferative syndrome, Malignant hemopathy, Genetics
- in
- European Journal of Haematology
- volume
- 62
- issue
- 3
- pages
- 184 - 190
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:10089896
- scopus:0032988154
- ISSN
- 1600-0609
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000), Division of Clinical Genetics (013022003)
- id
- 4f17039e-913e-4a70-bc87-c5ae64e39f94 (old id 1116066)
- date added to LUP
- 2016-04-01 12:09:53
- date last changed
- 2022-02-11 02:53:51
@article{4f17039e-913e-4a70-bc87-c5ae64e39f94,
abstract = {{A single institution series of 81 consecutive, cytogenetically analyzed, diffuse large B-cell lymphomas (DLBL), the majority of which treated with anthracycline-containing combination chemotherapy, were reviewed retrospectively to investigate whether the karyotypic pattern or certain abnormalities correlate with survival. Clonal chromosome changes were found in 79 of the 81 cases. The prognostic impact of the following aberrations, all suggested in previous studies to be associated with either shorter or longer survival, were tested: 1q21-23 breakpoints, +2/dup(2p), +3/dup(3p), +5, +6, 6q21-25 breakpoints, monosomy 7/der(7p)/i(7q), trisomy 7, 14q11-12 breakpoints, monosomy 17/der(17p)/i(17q), trisomy 18, > 4 marker chromosomes, > 4 breakpoints, and > or = 10 abnormalities. Univariate analysis showed that a breakpoint at 1q21-23 or trisomy 6 was associated with a shorter survival. However, when adjusted for age, stage, performance status and lactate dehydrogenase level, none of the cytogenetic aberrations had an independent prognostic value. Thus, the present investigation provides no support for any of the above-mentioned abnormalities being of prognostic importance in DLBL.}},
author = {{Jerkeman, Mats and Johansson, Bertil and Åkerman, Måns and Cavallin-Ståhl, Eva and Kristoffersson, Ulf and Mitelman, Felix}},
issn = {{1600-0609}},
keywords = {{B-Lymphocyte; Large cell lymphoma; Chromosomal aberration; Cytogenetics; Prognosis; Human; Non Hodgkin lymphoma; Lymphoproliferative syndrome; Malignant hemopathy; Genetics}},
language = {{eng}},
number = {{3}},
pages = {{184--190}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Haematology}},
title = {{Prognostic implications of cytogenetic aberrations in diffuse large B-cell lymphomas}},
volume = {{62}},
year = {{1999}},
}