Helicobacter pylori infection is associated with a decreased risk of developing oesophageal neoplasms
(2001) In Helicobacter 6(4). p.310-316- Abstract
- Background. The role of Helicobacter pylori infection in the development of oesophageal malignancies was investigated through a multivariate conditional logistic regression analysis in a nested case-control study. Methods. Blood samples and a questionnaire on smoking and alcohol habits were collected from a cohort of 32,906 city residents during a health-screening programme between 1974 and 1992. Forty-four cases of oesophageal cancer and 149 matched controls were selected. The mean interval between screening and cancer diagnosis was 11.9 years. H. pylori seropositivity was determined by an enzyme-linked immunosorbant assay measuring IgG. Occupation was included in the statistical analysis as an indicator of socio-economic status. Results.... (More)
- Background. The role of Helicobacter pylori infection in the development of oesophageal malignancies was investigated through a multivariate conditional logistic regression analysis in a nested case-control study. Methods. Blood samples and a questionnaire on smoking and alcohol habits were collected from a cohort of 32,906 city residents during a health-screening programme between 1974 and 1992. Forty-four cases of oesophageal cancer and 149 matched controls were selected. The mean interval between screening and cancer diagnosis was 11.9 years. H. pylori seropositivity was determined by an enzyme-linked immunosorbant assay measuring IgG. Occupation was included in the statistical analysis as an indicator of socio-economic status. Results. Helicobacter pylori seropositivity was present in 10 of the cases (22.7%) and 67 of the controls (45.0%). In a multivariate model, vith adjustment for occupation, tobacco and alcohol consumption, the odds ratio for developing in oesophageal malignancy when infected with H. pylori was 0.29 (95% confidence interval (CI): 0.12-0.67). Current smokers had an odds ratio of 17.3 (95% Cl: 3.0-99.4) and the odds ratio for ex-smokers was 5.9 (95% CI: 1.15-29.9). High alcohol consumption was no longer significantly, associated with oesophageal neoplasms after tobacco smoking was included into the model, odds ratio 1.22 (95% CI: 0.46-3.2). The protective effect of H. pylori was more pronounced for oesophageal adenocarcinoma (seven cases, odds ratio 0.16, 95% Cl: 0.00-1.06) than for squamous-cell carcinoma (29 cases, odds ratio 0.41, 95% Cl: 0.14-1.2). Conclusions. Helicobacter pylori infection is associated with a decreased risk of developing an oesophageal malignancy. Current smokers and ex-smokers have instead a definite increased risk of oesophageal neoplasms. (Less)
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https://lup.lub.lu.se/record/1118552
- author
- Simán, Henrik LU ; Forsgren, Arne LU ; Berglund, Göran LU and Florén, Claes-Henrik LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Oesophageal neoplasm, Helicobacter pylori, nested case-control study
- in
- Helicobacter
- volume
- 6
- issue
- 4
- pages
- 310 - 316
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000172806800007
- scopus:0035660684
- ISSN
- 1083-4389
- DOI
- 10.1046/j.1523-5378.2001.00041.x
- language
- English
- LU publication?
- yes
- id
- 44aa0bc8-6b43-437b-9915-71e6fad12657 (old id 1118552)
- date added to LUP
- 2016-04-01 12:02:55
- date last changed
- 2024-02-23 17:00:25
@article{44aa0bc8-6b43-437b-9915-71e6fad12657,
abstract = {{Background. The role of Helicobacter pylori infection in the development of oesophageal malignancies was investigated through a multivariate conditional logistic regression analysis in a nested case-control study. Methods. Blood samples and a questionnaire on smoking and alcohol habits were collected from a cohort of 32,906 city residents during a health-screening programme between 1974 and 1992. Forty-four cases of oesophageal cancer and 149 matched controls were selected. The mean interval between screening and cancer diagnosis was 11.9 years. H. pylori seropositivity was determined by an enzyme-linked immunosorbant assay measuring IgG. Occupation was included in the statistical analysis as an indicator of socio-economic status. Results. Helicobacter pylori seropositivity was present in 10 of the cases (22.7%) and 67 of the controls (45.0%). In a multivariate model, vith adjustment for occupation, tobacco and alcohol consumption, the odds ratio for developing in oesophageal malignancy when infected with H. pylori was 0.29 (95% confidence interval (CI): 0.12-0.67). Current smokers had an odds ratio of 17.3 (95% Cl: 3.0-99.4) and the odds ratio for ex-smokers was 5.9 (95% CI: 1.15-29.9). High alcohol consumption was no longer significantly, associated with oesophageal neoplasms after tobacco smoking was included into the model, odds ratio 1.22 (95% CI: 0.46-3.2). The protective effect of H. pylori was more pronounced for oesophageal adenocarcinoma (seven cases, odds ratio 0.16, 95% Cl: 0.00-1.06) than for squamous-cell carcinoma (29 cases, odds ratio 0.41, 95% Cl: 0.14-1.2). Conclusions. Helicobacter pylori infection is associated with a decreased risk of developing an oesophageal malignancy. Current smokers and ex-smokers have instead a definite increased risk of oesophageal neoplasms.}},
author = {{Simán, Henrik and Forsgren, Arne and Berglund, Göran and Florén, Claes-Henrik}},
issn = {{1083-4389}},
keywords = {{Oesophageal neoplasm; Helicobacter pylori; nested case-control study}},
language = {{eng}},
number = {{4}},
pages = {{310--316}},
publisher = {{Wiley-Blackwell}},
series = {{Helicobacter}},
title = {{Helicobacter pylori infection is associated with a decreased risk of developing oesophageal neoplasms}},
url = {{http://dx.doi.org/10.1046/j.1523-5378.2001.00041.x}},
doi = {{10.1046/j.1523-5378.2001.00041.x}},
volume = {{6}},
year = {{2001}},
}