CSF studies in violent offenders. II. Blood-brain barrier dysfunction without concurrent inflammation or structure degeneration
(2001) In Journal of Neural Transmission 108(7). p.879-886- Abstract
- Cerebral dysfunction without corresponding structural pathology has been reported in brain imaging studies of violent offenders. Biochemical markers in the CSF reflect various types of CNS pathology, such as blood-brain barrier dysfunction (CSF/S albumin ratio), infectious or inflammatory processes (IgG and IgM indices), neuronal or axonal degeneration (CSF-tau protein) and synaptic de- or regeneration (CSF-growth associated protein-43 (GAP-43)). We compared these CSF markers in 19 non-psychotic perpetrators of severe violent crimes undergoing pretrial forensic psychiatric investigation and 19 age- and sex-matched controls. Index subjects had significantly higher albumin ratios (p = 0.002), indicating abnormal vascular permeability as part... (More)
- Cerebral dysfunction without corresponding structural pathology has been reported in brain imaging studies of violent offenders. Biochemical markers in the CSF reflect various types of CNS pathology, such as blood-brain barrier dysfunction (CSF/S albumin ratio), infectious or inflammatory processes (IgG and IgM indices), neuronal or axonal degeneration (CSF-tau protein) and synaptic de- or regeneration (CSF-growth associated protein-43 (GAP-43)). We compared these CSF markers in 19 non-psychotic perpetrators of severe violent crimes undergoing pretrial forensic psychiatric investigation and 19 age- and sex-matched controls. Index subjects had significantly higher albumin ratios (p = 0.002), indicating abnormal vascular permeability as part of the complex CNS dysfunction previously reported in violent offenders. Axis I disorders, including substance abuse or current medication, did not explain this finding. Since Ig-indices, CSF-tau protein or CSF-GAP-43 were not increased, there was no support for inflammation or neuronal/synaptic degeneration as etiological factors to CNS dysfunction in this category of subjects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1120698
- author
- Söderström, Henrik LU ; Blennow, Kaj LU ; Manhem, A. and Forsman, A
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Violence, offenders, blood-brain barrier, tau-protein, GAP-43
- in
- Journal of Neural Transmission
- volume
- 108
- issue
- 7
- pages
- 879 - 886
- publisher
- Springer
- external identifiers
-
- pmid:11515753
- scopus:0034914640
- ISSN
- 0300-9564
- DOI
- 10.1007/s007020170037
- language
- English
- LU publication?
- no
- id
- 759fe1a8-e1a4-4227-abb9-6bfebe49e8d9 (old id 1120698)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/11515753
- http://link.springer.com/article/10.1007%2Fs007020170037
- date added to LUP
- 2016-04-01 17:03:24
- date last changed
- 2022-01-29 00:01:04
@article{759fe1a8-e1a4-4227-abb9-6bfebe49e8d9, abstract = {{Cerebral dysfunction without corresponding structural pathology has been reported in brain imaging studies of violent offenders. Biochemical markers in the CSF reflect various types of CNS pathology, such as blood-brain barrier dysfunction (CSF/S albumin ratio), infectious or inflammatory processes (IgG and IgM indices), neuronal or axonal degeneration (CSF-tau protein) and synaptic de- or regeneration (CSF-growth associated protein-43 (GAP-43)). We compared these CSF markers in 19 non-psychotic perpetrators of severe violent crimes undergoing pretrial forensic psychiatric investigation and 19 age- and sex-matched controls. Index subjects had significantly higher albumin ratios (p = 0.002), indicating abnormal vascular permeability as part of the complex CNS dysfunction previously reported in violent offenders. Axis I disorders, including substance abuse or current medication, did not explain this finding. Since Ig-indices, CSF-tau protein or CSF-GAP-43 were not increased, there was no support for inflammation or neuronal/synaptic degeneration as etiological factors to CNS dysfunction in this category of subjects.}}, author = {{Söderström, Henrik and Blennow, Kaj and Manhem, A. and Forsman, A}}, issn = {{0300-9564}}, keywords = {{Violence; offenders; blood-brain barrier; tau-protein; GAP-43}}, language = {{eng}}, number = {{7}}, pages = {{879--886}}, publisher = {{Springer}}, series = {{Journal of Neural Transmission}}, title = {{CSF studies in violent offenders. II. Blood-brain barrier dysfunction without concurrent inflammation or structure degeneration}}, url = {{http://dx.doi.org/10.1007/s007020170037}}, doi = {{10.1007/s007020170037}}, volume = {{108}}, year = {{2001}}, }