Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death
(2001) In Brain Research Bulletin 56(3-4). p.331-335- Abstract
- In hereditary Huntington's disease, a triplet repeat disease, there is extensive loss of striatal neurons. It has been shown that brain-derived neurotrophic factor (BDNF) protects striatal neurons against a variety of insults. We confirmed that BDNF enhances survival and DARPP-32 expression in primary striatal cultures derived from postnatal mice. Furthermore, BDNF inhibited intracellular oxyradical stress triggered by dopamine, and partially blocked basal and dopamine-induced apoptosis. Nevertheless, BDNF failed to rescue striatal neurons from dopamine-induced cell death. Therefore, BDNF inhibits free radical and apoptotic pathways in medium spiny neurons, but does so downstream from the point of commitment to cell death.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1121754
- author
- Petersén, Åsa LU ; Larsen, K E ; Behr, G G ; Romero, N ; Przedborski, S ; Brundin, Patrik LU and Sulzer, D
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Huntington’s disease, Autophagy, DARPP-32, Medium spiny neuron
- in
- Brain Research Bulletin
- volume
- 56
- issue
- 3-4
- pages
- 331 - 335
- publisher
- Elsevier
- external identifiers
-
- pmid:11719268
- scopus:0035503713
- ISSN
- 0361-9230
- DOI
- 10.1016/S0361-9230(01)00580-9
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Translational Neuroendocrinology (013210010)
- id
- 921b92bc-20a5-40a9-a0b6-33570ff34050 (old id 1121754)
- date added to LUP
- 2016-04-01 11:39:11
- date last changed
- 2022-01-26 08:11:16
@article{921b92bc-20a5-40a9-a0b6-33570ff34050, abstract = {{In hereditary Huntington's disease, a triplet repeat disease, there is extensive loss of striatal neurons. It has been shown that brain-derived neurotrophic factor (BDNF) protects striatal neurons against a variety of insults. We confirmed that BDNF enhances survival and DARPP-32 expression in primary striatal cultures derived from postnatal mice. Furthermore, BDNF inhibited intracellular oxyradical stress triggered by dopamine, and partially blocked basal and dopamine-induced apoptosis. Nevertheless, BDNF failed to rescue striatal neurons from dopamine-induced cell death. Therefore, BDNF inhibits free radical and apoptotic pathways in medium spiny neurons, but does so downstream from the point of commitment to cell death.}}, author = {{Petersén, Åsa and Larsen, K E and Behr, G G and Romero, N and Przedborski, S and Brundin, Patrik and Sulzer, D}}, issn = {{0361-9230}}, keywords = {{Huntington’s disease; Autophagy; DARPP-32; Medium spiny neuron}}, language = {{eng}}, number = {{3-4}}, pages = {{331--335}}, publisher = {{Elsevier}}, series = {{Brain Research Bulletin}}, title = {{Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death}}, url = {{http://dx.doi.org/10.1016/S0361-9230(01)00580-9}}, doi = {{10.1016/S0361-9230(01)00580-9}}, volume = {{56}}, year = {{2001}}, }