Limitations of chromosome classification by multicolor karyotyping
(2001) In American Journal of Human Genetics 68(4). p.1043-1047- Abstract
- Multicolor karyotyping technologies, such as spectral karyotyping (SKY) (Schrock et al.1996; Liyanage et al. 1996) and multiplex (M-) FISH (Speicher et al. 1996), have proved to be extremely useful in prenatal, postnatal, and cancer cytogenetics. However, these technologies have inherent limitations that, in certain situations, may result in chromosomal misclassification. In this report, we present nine cases, which fall into five categories, in which multicolor karyotyping has produced erroneous interpretations. Most errors appear to have a similar mechanistic basis.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1121774
- author
- Lee, Charles ; Gisselsson Nord, David LU ; Jin, Charlotte LU ; Nordgren, Ann ; Ferguson, David O. ; Blennow, Elisabeth ; Fletcher, Jonathan A. and Morton, Cynthia C.
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Human Genetics
- volume
- 68
- issue
- 4
- pages
- 1043 - 1047
- publisher
- Cell Press
- external identifiers
-
- pmid:11222105
- scopus:0035074295
- ISSN
- 0002-9297
- DOI
- 10.1086/319503
- language
- English
- LU publication?
- yes
- id
- 140b2ec4-4f72-4592-9c3f-e01995fcc2ca (old id 1121774)
- date added to LUP
- 2016-04-01 11:36:59
- date last changed
- 2022-04-20 19:13:55
@article{140b2ec4-4f72-4592-9c3f-e01995fcc2ca, abstract = {{Multicolor karyotyping technologies, such as spectral karyotyping (SKY) (Schrock et al.1996; Liyanage et al. 1996) and multiplex (M-) FISH (Speicher et al. 1996), have proved to be extremely useful in prenatal, postnatal, and cancer cytogenetics. However, these technologies have inherent limitations that, in certain situations, may result in chromosomal misclassification. In this report, we present nine cases, which fall into five categories, in which multicolor karyotyping has produced erroneous interpretations. Most errors appear to have a similar mechanistic basis.}}, author = {{Lee, Charles and Gisselsson Nord, David and Jin, Charlotte and Nordgren, Ann and Ferguson, David O. and Blennow, Elisabeth and Fletcher, Jonathan A. and Morton, Cynthia C.}}, issn = {{0002-9297}}, language = {{eng}}, number = {{4}}, pages = {{1043--1047}}, publisher = {{Cell Press}}, series = {{American Journal of Human Genetics}}, title = {{Limitations of chromosome classification by multicolor karyotyping}}, url = {{http://dx.doi.org/10.1086/319503}}, doi = {{10.1086/319503}}, volume = {{68}}, year = {{2001}}, }