Hepatic cirrhosis increases sensitivity of kidney to endotoxin in rats
(2002) In Medical Science Monitor 8(2). p.56-60- Abstract
- BACKGROUND: Renal failure in cirrhotic patients is a severe complication and endotoxemia might be involved. We investigated the effect of endotoxin on renal function of cirrhotic rats and the potential protective role of N-acetylcysteine (NAC). MATERIAL/METHODS: Hepatic cirrhosis was generated in a rat model by carbon tetrachloride. Both cirrhotic and normal rats were insulted by endotoxin intravenously, while another cirrhotic group was pre-treated with NAC. Blood urea nitrogen (BUN) and creatinine were assayed eight hours later. The changes in serum tumor necrosis factor-a (TNF-a) were assayed by ELISA. The histological changes in the kidney were observed after hematoxylin and eosin staining. RESULTS: Endotoxin increased the BUN and... (More)
- BACKGROUND: Renal failure in cirrhotic patients is a severe complication and endotoxemia might be involved. We investigated the effect of endotoxin on renal function of cirrhotic rats and the potential protective role of N-acetylcysteine (NAC). MATERIAL/METHODS: Hepatic cirrhosis was generated in a rat model by carbon tetrachloride. Both cirrhotic and normal rats were insulted by endotoxin intravenously, while another cirrhotic group was pre-treated with NAC. Blood urea nitrogen (BUN) and creatinine were assayed eight hours later. The changes in serum tumor necrosis factor-a (TNF-a) were assayed by ELISA. The histological changes in the kidney were observed after hematoxylin and eosin staining. RESULTS: Endotoxin increased the BUN and creatinine levels in both normal and cirrhotic rats, with a much higher elevation in the latter group. TNF-a concentration was also increased by endotoxin; the changes are positively correlated with BUN and creatinine. NAC pretreatment significantly attenuates the effects of endotoxin on BUN, creatinine and TNF-a levels in cirrhotic rats with no improvement in systemic toxicity symptoms. There were no obvious histological changes in the kidney of these animals. CONCLUSIONS: Hepatic cirrhosis increased the sensitivity of renal function to endotoxemia, which may be protected by NAC. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1124145
- author
- Liu, Jian-Jun ; Wang, Ji-Yao ; Zhang, Chi ; Nilsson, Åke LU and Duan, Rui-Dong LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Medical Science Monitor
- volume
- 8
- issue
- 2
- pages
- 56 - 60
- publisher
- International Scientific Information (ISI)
- external identifiers
-
- pmid:11862160
- scopus:17644443866
- ISSN
- 1643-3750
- language
- English
- LU publication?
- yes
- id
- 97a8c9dd-92d0-4733-b51e-4ab9b76baa28 (old id 1124145)
- alternative location
- http://www.medscimonit.com/abstracted.php?level=5&icid=420918
- date added to LUP
- 2016-04-01 12:03:41
- date last changed
- 2024-02-23 17:16:39
@article{97a8c9dd-92d0-4733-b51e-4ab9b76baa28, abstract = {{BACKGROUND: Renal failure in cirrhotic patients is a severe complication and endotoxemia might be involved. We investigated the effect of endotoxin on renal function of cirrhotic rats and the potential protective role of N-acetylcysteine (NAC). MATERIAL/METHODS: Hepatic cirrhosis was generated in a rat model by carbon tetrachloride. Both cirrhotic and normal rats were insulted by endotoxin intravenously, while another cirrhotic group was pre-treated with NAC. Blood urea nitrogen (BUN) and creatinine were assayed eight hours later. The changes in serum tumor necrosis factor-a (TNF-a) were assayed by ELISA. The histological changes in the kidney were observed after hematoxylin and eosin staining. RESULTS: Endotoxin increased the BUN and creatinine levels in both normal and cirrhotic rats, with a much higher elevation in the latter group. TNF-a concentration was also increased by endotoxin; the changes are positively correlated with BUN and creatinine. NAC pretreatment significantly attenuates the effects of endotoxin on BUN, creatinine and TNF-a levels in cirrhotic rats with no improvement in systemic toxicity symptoms. There were no obvious histological changes in the kidney of these animals. CONCLUSIONS: Hepatic cirrhosis increased the sensitivity of renal function to endotoxemia, which may be protected by NAC.}}, author = {{Liu, Jian-Jun and Wang, Ji-Yao and Zhang, Chi and Nilsson, Åke and Duan, Rui-Dong}}, issn = {{1643-3750}}, language = {{eng}}, number = {{2}}, pages = {{56--60}}, publisher = {{International Scientific Information (ISI)}}, series = {{Medical Science Monitor}}, title = {{Hepatic cirrhosis increases sensitivity of kidney to endotoxin in rats}}, url = {{http://www.medscimonit.com/abstracted.php?level=5&icid=420918}}, volume = {{8}}, year = {{2002}}, }