Protein-free diets do not protect high-incidence diabetes-prone BioBreeding rats from diabetes.
(2002) In Metabolism: Clinical and Experimental 51(5). p.569-574- Abstract
- Dietary factors have been reported to affect the development of spontaneous diabetes in various colonies of inbred and outbred diabetes-prone (DP) BioBreeding (BB) rats. Several studies have attributed a protective effect to a diet omitting crude protein mixtures in favor of purified casein, hydrolyzed casein, or free amino acids. We have used inbred BB rats, all of which become diabetic in specific pathogen-free (SPF) conditions when fed ordinary rat chow, to test the capacity of 2 different protein-free diets to modulate BB rat diabetes in 2 distinct pathogen-free environments. BB rats known to all develop diabetes by 100 days of age were fed from birth with 1 of 3 diets. By 120 days of age, 100% of the animals on a standard diabetogenic... (More)
- Dietary factors have been reported to affect the development of spontaneous diabetes in various colonies of inbred and outbred diabetes-prone (DP) BioBreeding (BB) rats. Several studies have attributed a protective effect to a diet omitting crude protein mixtures in favor of purified casein, hydrolyzed casein, or free amino acids. We have used inbred BB rats, all of which become diabetic in specific pathogen-free (SPF) conditions when fed ordinary rat chow, to test the capacity of 2 different protein-free diets to modulate BB rat diabetes in 2 distinct pathogen-free environments. BB rats known to all develop diabetes by 100 days of age were fed from birth with 1 of 3 diets. By 120 days of age, 100% of the animals on a standard diabetogenic chow diet, 83% of animals on an amino acid-based protein-free diet, and 100% of animals on a hydrolyzed casein-based diet had developed diabetes (P >.05). A slight delay in the age of onset was observed among rats fed the amino acid-based diet, but t (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1124820
- author
- Simonson, W ; Ramanathan, S ; Bieg, S ; Poussier, P and Lernmark, Åke LU
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Metabolism: Clinical and Experimental
- volume
- 51
- issue
- 5
- pages
- 569 - 574
- publisher
- Elsevier
- external identifiers
-
- scopus:0036256865
- ISSN
- 0026-0495
- DOI
- 10.1053/meta.2002.31979
- language
- English
- LU publication?
- no
- id
- 3baef55f-7275-496d-9ba8-037bc4ba05a2 (old id 1124820)
- date added to LUP
- 2016-04-04 10:36:49
- date last changed
- 2022-01-29 20:31:39
@article{3baef55f-7275-496d-9ba8-037bc4ba05a2, abstract = {{Dietary factors have been reported to affect the development of spontaneous diabetes in various colonies of inbred and outbred diabetes-prone (DP) BioBreeding (BB) rats. Several studies have attributed a protective effect to a diet omitting crude protein mixtures in favor of purified casein, hydrolyzed casein, or free amino acids. We have used inbred BB rats, all of which become diabetic in specific pathogen-free (SPF) conditions when fed ordinary rat chow, to test the capacity of 2 different protein-free diets to modulate BB rat diabetes in 2 distinct pathogen-free environments. BB rats known to all develop diabetes by 100 days of age were fed from birth with 1 of 3 diets. By 120 days of age, 100% of the animals on a standard diabetogenic chow diet, 83% of animals on an amino acid-based protein-free diet, and 100% of animals on a hydrolyzed casein-based diet had developed diabetes (P >.05). A slight delay in the age of onset was observed among rats fed the amino acid-based diet, but t}}, author = {{Simonson, W and Ramanathan, S and Bieg, S and Poussier, P and Lernmark, Åke}}, issn = {{0026-0495}}, language = {{eng}}, number = {{5}}, pages = {{569--574}}, publisher = {{Elsevier}}, series = {{Metabolism: Clinical and Experimental}}, title = {{Protein-free diets do not protect high-incidence diabetes-prone BioBreeding rats from diabetes.}}, url = {{http://dx.doi.org/10.1053/meta.2002.31979}}, doi = {{10.1053/meta.2002.31979}}, volume = {{51}}, year = {{2002}}, }