Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study
(2004) In Journal of Infectious Diseases 190(9). p.1631-1641- Abstract
- Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI and FokI-ApaI that were driven by the increased transmission to affected offspring of the FokI F and ApaI A alleles in combination. The ApaI A allele was also transmitted to affected offspring significantly more often than expected. Case-control analysis showed no... (More)
- Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI and FokI-ApaI that were driven by the increased transmission to affected offspring of the FokI F and ApaI A alleles in combination. The ApaI A allele was also transmitted to affected offspring significantly more often than expected. Case-control analysis showed no statistically significant association between TB and VDR variants. BsmI, ApaI, and TaqI showed strong linkage disequilibrium. The significance of the family-based associations found between TB and FokI-BsmI-ApaI-TaqI and the FA haplotype supports a role for VDR haplotypes, rather than individual genotypes, in susceptibility to TB. (Less)
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https://lup.lub.lu.se/record/1129402
- author
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Infectious Diseases
- volume
- 190
- issue
- 9
- pages
- 1631 - 1641
- publisher
- Oxford University Press
- external identifiers
-
- pmid:15478069
- scopus:5444259819
- ISSN
- 1537-6613
- DOI
- 10.1086/424462
- language
- English
- LU publication?
- no
- id
- 402110bb-d117-4a49-9f31-38846d1b2645 (old id 1129402)
- date added to LUP
- 2016-04-01 15:31:19
- date last changed
- 2022-01-28 05:43:39
@article{402110bb-d117-4a49-9f31-38846d1b2645, abstract = {{Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI and FokI-ApaI that were driven by the increased transmission to affected offspring of the FokI F and ApaI A alleles in combination. The ApaI A allele was also transmitted to affected offspring significantly more often than expected. Case-control analysis showed no statistically significant association between TB and VDR variants. BsmI, ApaI, and TaqI showed strong linkage disequilibrium. The significance of the family-based associations found between TB and FokI-BsmI-ApaI-TaqI and the FA haplotype supports a role for VDR haplotypes, rather than individual genotypes, in susceptibility to TB.}}, author = {{Bornman, Liza and Campbell, Sarah J and Fielding, Katherine and Bah, Boubacar and Sillah, Jackson and Gustafson, Per and Manneh, Kebba and Lisse, Ida and Allen, Angela and Sirugo, Giorgio and Sylla, Aissatou and Aaby, Peter and McAdam, Keith P W J and Bah-Sow, Oumou and Bennett, Steve}}, issn = {{1537-6613}}, language = {{eng}}, number = {{9}}, pages = {{1631--1641}}, publisher = {{Oxford University Press}}, series = {{Journal of Infectious Diseases}}, title = {{Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study}}, url = {{http://dx.doi.org/10.1086/424462}}, doi = {{10.1086/424462}}, volume = {{190}}, year = {{2004}}, }