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Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells

Ittner, Lars M ; Wurdak, Heiko ; Schwerdtfeger, Kerstin ; Kunz, Thomas ; Ille, Fabian ; Levéen, Per LU ; Hjalt, Tord LU ; Suter, Ueli ; Karlsson, Stefan LU orcid and Hafezi, Farhad , et al. (2005) In Journal of Biology 4(11).
Abstract
BACKGROUND: Development of the eye depends partly on the periocular mesenchyme derived from the neural crest (NC), but the fate of NC cells in mammalian eye development and the signals coordinating the formation of ocular structures are poorly understood. RESULTS: Here we reveal distinct NC contributions to both anterior and posterior mesenchymal eye structures and show that TGFbeta signaling in these cells is crucial for normal eye development. In the anterior eye, TGFbeta2 released from the lens is required for the expression of transcription factors Pitx2 and Foxc1 in the NC-derived cornea and in the chamber-angle structures of the eye that control intraocular pressure. TGFbeta enhances Foxc1 and induces Pitx2 expression in cell... (More)
BACKGROUND: Development of the eye depends partly on the periocular mesenchyme derived from the neural crest (NC), but the fate of NC cells in mammalian eye development and the signals coordinating the formation of ocular structures are poorly understood. RESULTS: Here we reveal distinct NC contributions to both anterior and posterior mesenchymal eye structures and show that TGFbeta signaling in these cells is crucial for normal eye development. In the anterior eye, TGFbeta2 released from the lens is required for the expression of transcription factors Pitx2 and Foxc1 in the NC-derived cornea and in the chamber-angle structures of the eye that control intraocular pressure. TGFbeta enhances Foxc1 and induces Pitx2 expression in cell cultures. As in patients carrying mutations in PITX2 and FOXC1, TGFbeta signal inactivation in NC cells leads to ocular defects characteristic of the human disorder Axenfeld-Rieger's anomaly. In the posterior eye, NC cell-specific inactivation of TGFbeta signaling results in a condition reminiscent of the human disorder persistent hyperplastic primary vitreous. As a secondary effect, retinal patterning is also disturbed in mutant mice. CONCLUSION: In the developing eye the lens acts as a TGFbeta signaling center that controls the development of eye structures derived from the NC. Defective TGFbeta signal transduction interferes with NC-cell differentiation and survival anterior to the lens and with normal tissue morphogenesis and patterning posterior to the lens. The similarity to developmental eye disorders in humans suggests that defective TGFbeta signal modulation in ocular NC derivatives contributes to the pathophysiology of these diseases. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Biology
volume
4
issue
11
publisher
BioMed Central (BMC)
external identifiers
  • pmid:16403239
  • scopus:33645067959
  • pmid:16403239
ISSN
1475-4924
DOI
10.1186/jbiol29
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Division of Molecular Medicine and Gene Therapy (013022010), Paediatrics (Lund) (013002000)
id
d26541b8-d1db-47cf-87d3-d8bde02db500 (old id 1132334)
date added to LUP
2016-04-01 11:59:37
date last changed
2022-04-13 04:32:05
@article{d26541b8-d1db-47cf-87d3-d8bde02db500,
  abstract     = {{BACKGROUND: Development of the eye depends partly on the periocular mesenchyme derived from the neural crest (NC), but the fate of NC cells in mammalian eye development and the signals coordinating the formation of ocular structures are poorly understood. RESULTS: Here we reveal distinct NC contributions to both anterior and posterior mesenchymal eye structures and show that TGFbeta signaling in these cells is crucial for normal eye development. In the anterior eye, TGFbeta2 released from the lens is required for the expression of transcription factors Pitx2 and Foxc1 in the NC-derived cornea and in the chamber-angle structures of the eye that control intraocular pressure. TGFbeta enhances Foxc1 and induces Pitx2 expression in cell cultures. As in patients carrying mutations in PITX2 and FOXC1, TGFbeta signal inactivation in NC cells leads to ocular defects characteristic of the human disorder Axenfeld-Rieger's anomaly. In the posterior eye, NC cell-specific inactivation of TGFbeta signaling results in a condition reminiscent of the human disorder persistent hyperplastic primary vitreous. As a secondary effect, retinal patterning is also disturbed in mutant mice. CONCLUSION: In the developing eye the lens acts as a TGFbeta signaling center that controls the development of eye structures derived from the NC. Defective TGFbeta signal transduction interferes with NC-cell differentiation and survival anterior to the lens and with normal tissue morphogenesis and patterning posterior to the lens. The similarity to developmental eye disorders in humans suggests that defective TGFbeta signal modulation in ocular NC derivatives contributes to the pathophysiology of these diseases.}},
  author       = {{Ittner, Lars M and Wurdak, Heiko and Schwerdtfeger, Kerstin and Kunz, Thomas and Ille, Fabian and Levéen, Per and Hjalt, Tord and Suter, Ueli and Karlsson, Stefan and Hafezi, Farhad and Born, Walter and Sommer, Lukas}},
  issn         = {{1475-4924}},
  language     = {{eng}},
  number       = {{11}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Journal of Biology}},
  title        = {{Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells}},
  url          = {{http://dx.doi.org/10.1186/jbiol29}},
  doi          = {{10.1186/jbiol29}},
  volume       = {{4}},
  year         = {{2005}},
}