Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
(2005) In Journal of Clinical Investigation 115(1). p.118-127- Abstract
- The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
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https://lup.lub.lu.se/record/1132673
- author
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Investigation
- volume
- 115
- issue
- 1
- pages
- 118 - 127
- publisher
- The American Society for Clinical Investigation
- external identifiers
-
- pmid:15630451
- scopus:85047694353
- ISSN
- 0021-9738
- DOI
- 10.1172/JCI200519189
- language
- English
- LU publication?
- no
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematopoietic Stem Cell Laboratory (013022012)
- id
- 120de287-e6de-46eb-92d4-22b73325e5f9 (old id 1132673)
- date added to LUP
- 2016-04-01 16:03:21
- date last changed
- 2022-04-22 19:10:13
@article{120de287-e6de-46eb-92d4-22b73325e5f9, abstract = {{The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.}}, author = {{Li, Xuri and Tjwa, Marc and Moons, Lieve and Fons, Pierre and Noel, Agnes and Ny, Annelii and Zhou, Jian Min and Lennartsson, Johan and Li, Hong and Luttun, Aernout and Pontén, Annica and Devy, Laetitia and Bouche, Ann and Oh, Hideyasu and Manderveld, Ann and Blacher, Silvia and Communi, Davi}}, issn = {{0021-9738}}, language = {{eng}}, number = {{1}}, pages = {{118--127}}, publisher = {{The American Society for Clinical Investigation}}, series = {{Journal of Clinical Investigation}}, title = {{Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors}}, url = {{http://dx.doi.org/10.1172/JCI200519189}}, doi = {{10.1172/JCI200519189}}, volume = {{115}}, year = {{2005}}, }