Lung function, insulin resistance and incidence of cardiovascular disease: a longitudinal cohort study.
(2003) In Journal of Internal Medicine 253(5). p.574-581- Abstract
- Objectives. To explore whether a reduced lung function is a risk factor for developing diabetes and insulin resistance (IR), and whether such relationship contributes to the largely unexplained association between lung function and incidence of cardiovascular disease (CVD).
Design. Forced vital capacity (FVC) was assessed at baseline. Incidence of diabetes and IR [according to the homeostasis model assessment (HOMA) model] was assessed in a follow-up examination after 13.9 ± 2.6 and 9.4 ± 3.6 years for men and women, respectively. After the follow-up examination, incidence of CVD (stroke, myocardial infarction or cardiovascular death) was monitored over 7 years.
Setting. Populations-based cohort... (More) - Objectives. To explore whether a reduced lung function is a risk factor for developing diabetes and insulin resistance (IR), and whether such relationship contributes to the largely unexplained association between lung function and incidence of cardiovascular disease (CVD).
Design. Forced vital capacity (FVC) was assessed at baseline. Incidence of diabetes and IR [according to the homeostasis model assessment (HOMA) model] was assessed in a follow-up examination after 13.9 ± 2.6 and 9.4 ± 3.6 years for men and women, respectively. After the follow-up examination, incidence of CVD (stroke, myocardial infarction or cardiovascular death) was monitored over 7 years.
Setting. Populations-based cohort study.
Subjects. Initially nondiabetic men (n = 1436, mean age 44.6 years) and women (n = 896, mean age 49.8 years).
Results. Prevalence of IR at the follow-up examination was 34, 26, 21 and 21%, respectively, for men in the first (lowest), second, third and fourth quartile of baseline FVC (P for trend <0.0001). The corresponding values for women were 30, 29, 25 and 17%, respectively (P for trend <0.001). Adjusted for potential confounders, the odds ratio (OR) for IR (per 10% increase in FVC) was 0.91 (CI: 0.84-0.99) for men and 0.89 (CI: 0.80-0.98) for women. FVC was similarly significantly associated with the incidence of diabetes (OR = 0.90, CI: 0.81-1.00), adjusted for sex and other confounders.
The incidence of CVD after the follow-up examination was significantly increased only amongst subjects with low FVC who had developed IR (RR = 1.7, CI: 1.02-2.7).
Conclusion. Subjects with a moderately reduced FVC have an increased risk of developing IR and diabetes. This relationship seems to contribute to the largely unexplained association between reduced lung function and incidence of CVD. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/113299
- author
- Engström, Gunnar LU ; Hedblad, Bo LU ; Nilsson, P ; Wollmer, Per LU ; Berglund, Göran LU and Janzon, Lars LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Internal Medicine
- volume
- 253
- issue
- 5
- pages
- 574 - 581
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:12702035
- wos:000182323100010
- scopus:0037734258
- ISSN
- 1365-2796
- DOI
- 10.1046/j.1365-2796.2003.01138.x
- language
- English
- LU publication?
- yes
- id
- d6441afe-d1bf-4157-9eb9-82760c44a898 (old id 113299)
- date added to LUP
- 2016-04-01 16:21:25
- date last changed
- 2023-10-02 18:07:04
@article{d6441afe-d1bf-4157-9eb9-82760c44a898,
abstract = {{Objectives. To explore whether a reduced lung function is a risk factor for developing diabetes and insulin resistance (IR), and whether such relationship contributes to the largely unexplained association between lung function and incidence of cardiovascular disease (CVD).<br/><br>
<br/><br>
Design. Forced vital capacity (FVC) was assessed at baseline. Incidence of diabetes and IR [according to the homeostasis model assessment (HOMA) model] was assessed in a follow-up examination after 13.9 ± 2.6 and 9.4 ± 3.6 years for men and women, respectively. After the follow-up examination, incidence of CVD (stroke, myocardial infarction or cardiovascular death) was monitored over 7 years.<br/><br>
<br/><br>
Setting. Populations-based cohort study.<br/><br>
<br/><br>
Subjects. Initially nondiabetic men (n = 1436, mean age 44.6 years) and women (n = 896, mean age 49.8 years).<br/><br>
<br/><br>
Results. Prevalence of IR at the follow-up examination was 34, 26, 21 and 21%, respectively, for men in the first (lowest), second, third and fourth quartile of baseline FVC (P for trend <0.0001). The corresponding values for women were 30, 29, 25 and 17%, respectively (P for trend <0.001). Adjusted for potential confounders, the odds ratio (OR) for IR (per 10% increase in FVC) was 0.91 (CI: 0.84-0.99) for men and 0.89 (CI: 0.80-0.98) for women. FVC was similarly significantly associated with the incidence of diabetes (OR = 0.90, CI: 0.81-1.00), adjusted for sex and other confounders.<br/><br>
<br/><br>
The incidence of CVD after the follow-up examination was significantly increased only amongst subjects with low FVC who had developed IR (RR = 1.7, CI: 1.02-2.7).<br/><br>
<br/><br>
Conclusion. Subjects with a moderately reduced FVC have an increased risk of developing IR and diabetes. This relationship seems to contribute to the largely unexplained association between reduced lung function and incidence of CVD.}},
author = {{Engström, Gunnar and Hedblad, Bo and Nilsson, P and Wollmer, Per and Berglund, Göran and Janzon, Lars}},
issn = {{1365-2796}},
language = {{eng}},
number = {{5}},
pages = {{574--581}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Internal Medicine}},
title = {{Lung function, insulin resistance and incidence of cardiovascular disease: a longitudinal cohort study.}},
url = {{https://lup.lub.lu.se/search/files/4647917/623738.pdf}},
doi = {{10.1046/j.1365-2796.2003.01138.x}},
volume = {{253}},
year = {{2003}},
}