Role of gamma/delta T cell receptor-expressing lymphocytes in cutaneous infection caused by Staphylococcus aureus.
(2003) In Clinical and Experimental Immunology 132(2). p.209-215- Abstract
- The high number of /-expressing T cells found in the epithelial lining layer suggests that they form a first line of defence against invading pathogens. To evaluate the role of / T cell-receptor (TCR)-expressing cells in cutaneous infection caused by Staphylococcus aureus, mice lacking /-expressing T cells (TCR/) were inoculated intradermally with S. aureus, and compared with S. aureus-infected congeneic TCR+/ control mice. The number of bacteria recovered from the skin of TCR/ mice was significantly higher (P = 0·0071) at early time-points after inoculation compared to the number of bacteria isolated from infected TCR+/ congeneic controls. Nevertheless, inflammatory responses measured as serum IL-6 levels, were significantly lower in TCR/... (More)
- The high number of /-expressing T cells found in the epithelial lining layer suggests that they form a first line of defence against invading pathogens. To evaluate the role of / T cell-receptor (TCR)-expressing cells in cutaneous infection caused by Staphylococcus aureus, mice lacking /-expressing T cells (TCR/) were inoculated intradermally with S. aureus, and compared with S. aureus-infected congeneic TCR+/ control mice. The number of bacteria recovered from the skin of TCR/ mice was significantly higher (P = 0·0071) at early time-points after inoculation compared to the number of bacteria isolated from infected TCR+/ congeneic controls. Nevertheless, inflammatory responses measured as serum IL-6 levels, were significantly lower in TCR/ mice than in the control group. A possible explanation for this discrepancy was the observation of significantly decreased overall numbers of infiltrating cutaneous T lymphocytes, which are important producers of IL-6. These results support the notion that the /-expressing T cells that reside at the epithelial lining layer of the skin is of importance for early containment of the bacteria, thereby limiting their replication and spread. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/113356
- author
- Mölne, L ; Corthay, A ; Holmdahl, Rikard LU and Tarkowski, A
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical and Experimental Immunology
- volume
- 132
- issue
- 2
- pages
- 209 - 215
- publisher
- British Society for Immunology
- external identifiers
-
- wos:000182305500005
- pmid:12699407
- scopus:0038216948
- ISSN
- 0009-9104
- DOI
- 10.1046/j.1365-2249.2003.02151.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
- id
- 3ecce5d0-11c3-4b65-a416-1a0c1360b851 (old id 113356)
- date added to LUP
- 2016-04-01 12:08:20
- date last changed
- 2022-01-26 23:19:42
@article{3ecce5d0-11c3-4b65-a416-1a0c1360b851, abstract = {{The high number of /-expressing T cells found in the epithelial lining layer suggests that they form a first line of defence against invading pathogens. To evaluate the role of / T cell-receptor (TCR)-expressing cells in cutaneous infection caused by Staphylococcus aureus, mice lacking /-expressing T cells (TCR/) were inoculated intradermally with S. aureus, and compared with S. aureus-infected congeneic TCR+/ control mice. The number of bacteria recovered from the skin of TCR/ mice was significantly higher (P = 0·0071) at early time-points after inoculation compared to the number of bacteria isolated from infected TCR+/ congeneic controls. Nevertheless, inflammatory responses measured as serum IL-6 levels, were significantly lower in TCR/ mice than in the control group. A possible explanation for this discrepancy was the observation of significantly decreased overall numbers of infiltrating cutaneous T lymphocytes, which are important producers of IL-6. These results support the notion that the /-expressing T cells that reside at the epithelial lining layer of the skin is of importance for early containment of the bacteria, thereby limiting their replication and spread.}}, author = {{Mölne, L and Corthay, A and Holmdahl, Rikard and Tarkowski, A}}, issn = {{0009-9104}}, language = {{eng}}, number = {{2}}, pages = {{209--215}}, publisher = {{British Society for Immunology}}, series = {{Clinical and Experimental Immunology}}, title = {{Role of gamma/delta T cell receptor-expressing lymphocytes in cutaneous infection caused by Staphylococcus aureus.}}, url = {{https://lup.lub.lu.se/search/files/2797544/623742.pdf}}, doi = {{10.1046/j.1365-2249.2003.02151.x}}, volume = {{132}}, year = {{2003}}, }