Vasodilation effect of atropine on rat mesenteric artery
(2005) In Yao Xue Xue Bao 40(5). p.402-405- Abstract
- AIM: To study the vasodilation effect of atropine and its mechanism. METHODS: Isometric tension was recorded in isolated rat super mesenteric arteries precontracted by noradrenaline (NE) to study the vasodilation effect of atropine, and to investigate the role of endothelial cell and vascular smooth muscle cell on vasodilation. RESULTS: Atropine was shown to significantly dilate the endothelium-intact and endothelium-denuded arteries precontracted by NE. Nomega-Nitro-L-arginine methyl ester (L-NAME, nitric oxide synthase inhabitor), indomethacin (cyclooxygenase inhibitor), propranolol (general beta adrenoceptor antagonist) and glibenclamide (ATP sensitive potassium channel inhibitor) showed no effect on vasodilation of atropine. Atropine... (More)
- AIM: To study the vasodilation effect of atropine and its mechanism. METHODS: Isometric tension was recorded in isolated rat super mesenteric arteries precontracted by noradrenaline (NE) to study the vasodilation effect of atropine, and to investigate the role of endothelial cell and vascular smooth muscle cell on vasodilation. RESULTS: Atropine was shown to significantly dilate the endothelium-intact and endothelium-denuded arteries precontracted by NE. Nomega-Nitro-L-arginine methyl ester (L-NAME, nitric oxide synthase inhabitor), indomethacin (cyclooxygenase inhibitor), propranolol (general beta adrenoceptor antagonist) and glibenclamide (ATP sensitive potassium channel inhibitor) showed no effect on vasodilation of atropine. Atropine did not affect the concentration-contraction curve of K+. However, atropine suppressed the contraction induced by NE and CaCl2, but not that by caffeine in the Ca+ -free Krebs solution. CONCLUSION: Atropine showed significant vasodilation effect which may derive, in part, from endothelium. Besides, atropine could inhibit the receptor-mediated Ca2+ -influx and Ca2+ -release, which was inferred to the mechanism of atropine on vasodilation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1133934
- author
- Zheng, Jianpu LU ; Cao, Y X ; Xu, Cang-Bao LU and Edvinsson, Lars LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Yao Xue Xue Bao
- volume
- 40
- issue
- 5
- pages
- 402 - 405
- publisher
- Chinese Electronic Periodical Services
- external identifiers
-
- scopus:22244475403
- ISSN
- 0513-4870
- language
- English
- LU publication?
- yes
- id
- 85de6cc1-96db-44d3-830d-0d763f6efa5f (old id 1133934)
- date added to LUP
- 2016-04-01 15:39:44
- date last changed
- 2024-01-10 18:07:11
@article{85de6cc1-96db-44d3-830d-0d763f6efa5f, abstract = {{AIM: To study the vasodilation effect of atropine and its mechanism. METHODS: Isometric tension was recorded in isolated rat super mesenteric arteries precontracted by noradrenaline (NE) to study the vasodilation effect of atropine, and to investigate the role of endothelial cell and vascular smooth muscle cell on vasodilation. RESULTS: Atropine was shown to significantly dilate the endothelium-intact and endothelium-denuded arteries precontracted by NE. Nomega-Nitro-L-arginine methyl ester (L-NAME, nitric oxide synthase inhabitor), indomethacin (cyclooxygenase inhibitor), propranolol (general beta adrenoceptor antagonist) and glibenclamide (ATP sensitive potassium channel inhibitor) showed no effect on vasodilation of atropine. Atropine did not affect the concentration-contraction curve of K+. However, atropine suppressed the contraction induced by NE and CaCl2, but not that by caffeine in the Ca+ -free Krebs solution. CONCLUSION: Atropine showed significant vasodilation effect which may derive, in part, from endothelium. Besides, atropine could inhibit the receptor-mediated Ca2+ -influx and Ca2+ -release, which was inferred to the mechanism of atropine on vasodilation.}}, author = {{Zheng, Jianpu and Cao, Y X and Xu, Cang-Bao and Edvinsson, Lars}}, issn = {{0513-4870}}, language = {{eng}}, number = {{5}}, pages = {{402--405}}, publisher = {{Chinese Electronic Periodical Services}}, series = {{Yao Xue Xue Bao}}, title = {{Vasodilation effect of atropine on rat mesenteric artery}}, volume = {{40}}, year = {{2005}}, }