Extended operation with or without intraoperative (IORT) and external (EBRT) radiotherapy for gallbladder carcinoma.
(2003) In Hepato-Gastroenterology 50(50). p.310-314- Abstract
- BACKGROUND/AIMS: Gallbladder carcinoma is a rare disease with dismal prognosis. However, lately improved survival has been reported after extended operation including liver resection and lymphadenectomy in addition to cholecystectomy. The aim of this study was to evaluate such a surgical strategy with and without adjuvant intra- and postoperative radiotherapy (IORT/EBRT). METHODOLOGY: 20 patients underwent extended operation and the last 10 of them IORT/EBRT in addition. Tumor staging was done using the TNM system, determination of histological tumor differentiation and immunohistochemical assessment of p53, Ki67, metallothionein, deleted in colorectal cancer and carcinoembryogenic antigen in tumor tissue. RESULTS: There was no hospital... (More)
- BACKGROUND/AIMS: Gallbladder carcinoma is a rare disease with dismal prognosis. However, lately improved survival has been reported after extended operation including liver resection and lymphadenectomy in addition to cholecystectomy. The aim of this study was to evaluate such a surgical strategy with and without adjuvant intra- and postoperative radiotherapy (IORT/EBRT). METHODOLOGY: 20 patients underwent extended operation and the last 10 of them IORT/EBRT in addition. Tumor staging was done using the TNM system, determination of histological tumor differentiation and immunohistochemical assessment of p53, Ki67, metallothionein, deleted in colorectal cancer and carcinoembryogenic antigen in tumor tissue. RESULTS: There was no hospital mortality. Postoperative complications occurred in 3 patients (15%). Actuarial 5-year survival was 47% in the radiotherapy group and 13% after operation only (NS). The corresponding figures for median survival are 28.8 and 20.2 months, respectively. Five patients are still alive in the radiotherapy group. There was no difference in tumour stages of the two groups irrespective of the way of evaluation. CONCLUSIONS: The results suggest that extended operation for gallbladder carcinoma +/- IORT/EBRT can be done safely. The tendency to longer survival after adjuvant radiotherapy was not statistically significant. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/114023
- author
- Lindell, Gert LU ; Holmin, Torsten ; Ewers, Sven Börje ; Tranberg, Karl-Göran LU ; Stenram, Unne LU and Ihse, Ingemar LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Hepato-Gastroenterology
- volume
- 50
- issue
- 50
- pages
- 310 - 314
- publisher
- Georg Thieme Verlag
- external identifiers
-
- wos:000181979800004
- scopus:0037351581
- ISSN
- 0172-6390
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Surgery (Lund) (013009000), Oncology, MV (013035000)
- id
- 7e0a6bff-4fd4-4d67-816a-4d3fbe6ce03f (old id 114023)
- alternative location
- http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12749210&dopt=Abstract
- date added to LUP
- 2016-04-01 16:49:36
- date last changed
- 2022-01-28 22:28:30
@article{7e0a6bff-4fd4-4d67-816a-4d3fbe6ce03f, abstract = {{BACKGROUND/AIMS: Gallbladder carcinoma is a rare disease with dismal prognosis. However, lately improved survival has been reported after extended operation including liver resection and lymphadenectomy in addition to cholecystectomy. The aim of this study was to evaluate such a surgical strategy with and without adjuvant intra- and postoperative radiotherapy (IORT/EBRT). METHODOLOGY: 20 patients underwent extended operation and the last 10 of them IORT/EBRT in addition. Tumor staging was done using the TNM system, determination of histological tumor differentiation and immunohistochemical assessment of p53, Ki67, metallothionein, deleted in colorectal cancer and carcinoembryogenic antigen in tumor tissue. RESULTS: There was no hospital mortality. Postoperative complications occurred in 3 patients (15%). Actuarial 5-year survival was 47% in the radiotherapy group and 13% after operation only (NS). The corresponding figures for median survival are 28.8 and 20.2 months, respectively. Five patients are still alive in the radiotherapy group. There was no difference in tumour stages of the two groups irrespective of the way of evaluation. CONCLUSIONS: The results suggest that extended operation for gallbladder carcinoma +/- IORT/EBRT can be done safely. The tendency to longer survival after adjuvant radiotherapy was not statistically significant.}}, author = {{Lindell, Gert and Holmin, Torsten and Ewers, Sven Börje and Tranberg, Karl-Göran and Stenram, Unne and Ihse, Ingemar}}, issn = {{0172-6390}}, language = {{eng}}, number = {{50}}, pages = {{310--314}}, publisher = {{Georg Thieme Verlag}}, series = {{Hepato-Gastroenterology}}, title = {{Extended operation with or without intraoperative (IORT) and external (EBRT) radiotherapy for gallbladder carcinoma.}}, url = {{http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12749210&dopt=Abstract}}, volume = {{50}}, year = {{2003}}, }