Tourniquet compression: a non-invasive method to enhance nerve regeneration in nerve grafts.
Widerberg, Annika LU ; Kanje, Martin LU and Dahlin, Lars LU
(2002)
In NeuroReport
13(4).
p.371-375
- Abstract
- One hindlimb of a rat was subjected to tourniquet compression (150, 200 and 300 mmHg; 2 h). After 6 days a 10 mm sciatic or tibial nerve graft from the compressed limb was sutured to bridge a 3-4 mm gap in the sciatic nerve of the non-compressed limb. The distances of regenerating sensory axons were measured 6 days post surgery (tibial grafts, 8 days). Compression at 200 and 300 mmHg led to significantly longer regeneration distances than those seen in controls. Incorporation of BrdU and expression of p75 receptor by non-neuronal cells (Schwann cells) in sciatic nerves 6 days after compression (150 and 300 mmHg; 2 h) was also increased as a sign of Schwann cell activation. Tourniquet compression may be used as a non-invasive method to... (More)
- One hindlimb of a rat was subjected to tourniquet compression (150, 200 and 300 mmHg; 2 h). After 6 days a 10 mm sciatic or tibial nerve graft from the compressed limb was sutured to bridge a 3-4 mm gap in the sciatic nerve of the non-compressed limb. The distances of regenerating sensory axons were measured 6 days post surgery (tibial grafts, 8 days). Compression at 200 and 300 mmHg led to significantly longer regeneration distances than those seen in controls. Incorporation of BrdU and expression of p75 receptor by non-neuronal cells (Schwann cells) in sciatic nerves 6 days after compression (150 and 300 mmHg; 2 h) was also increased as a sign of Schwann cell activation. Tourniquet compression may be used as a non-invasive method to enhance nerve regeneration in nerve grafts. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/115459
- author
- Widerberg, Annika
LU
; Kanje, Martin
LU
and Dahlin, Lars
LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Nerve Regeneration: physiology, Rats, Receptor, Animal, Female, Graft Survival: physiology, Wistar, Nerve Growth Factor: physiology, Sciatic Nerve: injuries, Sciatic Nerve: physiology, Sciatic Nerve: transplantation, Support, Non-U.S. Gov't, Tourniquets, Transplants
- in
- NeuroReport
- volume
- 13
- issue
- 4
- pages
- 371 - 375
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:11930143
- wos:000174971300002
- scopus:0037171086
- ISSN
- 1473-558X
- DOI
- 10.1097/00001756-200203250-00002
- language
- English
- LU publication?
- yes
- id
- 15640526-e109-4436-a1ad-34585f3e97c9 (old id 115459)
- date added to LUP
- 2016-04-01 11:46:52
- date last changed
- 2022-01-26 18:07:55
@article{15640526-e109-4436-a1ad-34585f3e97c9,
abstract = {{One hindlimb of a rat was subjected to tourniquet compression (150, 200 and 300 mmHg; 2 h). After 6 days a 10 mm sciatic or tibial nerve graft from the compressed limb was sutured to bridge a 3-4 mm gap in the sciatic nerve of the non-compressed limb. The distances of regenerating sensory axons were measured 6 days post surgery (tibial grafts, 8 days). Compression at 200 and 300 mmHg led to significantly longer regeneration distances than those seen in controls. Incorporation of BrdU and expression of p75 receptor by non-neuronal cells (Schwann cells) in sciatic nerves 6 days after compression (150 and 300 mmHg; 2 h) was also increased as a sign of Schwann cell activation. Tourniquet compression may be used as a non-invasive method to enhance nerve regeneration in nerve grafts.}},
author = {{Widerberg, Annika and Kanje, Martin and Dahlin, Lars}},
issn = {{1473-558X}},
keywords = {{Nerve Regeneration: physiology; Rats; Receptor; Animal; Female; Graft Survival: physiology; Wistar; Nerve Growth Factor: physiology; Sciatic Nerve: injuries; Sciatic Nerve: physiology; Sciatic Nerve: transplantation; Support; Non-U.S. Gov't; Tourniquets; Transplants}},
language = {{eng}},
number = {{4}},
pages = {{371--375}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{NeuroReport}},
title = {{Tourniquet compression: a non-invasive method to enhance nerve regeneration in nerve grafts.}},
url = {{http://dx.doi.org/10.1097/00001756-200203250-00002}},
doi = {{10.1097/00001756-200203250-00002}},
volume = {{13}},
year = {{2002}},
}