Family history of cancer as a risk factor for second malignancies after Hodgkin's lymphoma
(2008) In British Journal of Cancer 98(5). p.1001-1005- Abstract
- This study estimated the risk of second primary malignancies after Hodgkin's lymphoma (HL) in relation to family history of cancer, age at diagnosis and latency, among 6946 patients treated for HL in Sweden in 1965-1995 identified through the Swedish Cancer Register (SCR). First-degree relatives (FDRs) to the HL patients and their malignancies were then ascertained together with their malignancies through the Multi-Generation Registry and SCR. The HL patient cohort was stratified on the number of FDRs with cancer, and standardised incidence ratios (SIRs) of developing SM were analysed. In the HL cohort, 781 SM were observed 1 year or longer after HL diagnosis. The risk for developing SM increased with the number of FDRs with cancer, SIRs... (More)
- This study estimated the risk of second primary malignancies after Hodgkin's lymphoma (HL) in relation to family history of cancer, age at diagnosis and latency, among 6946 patients treated for HL in Sweden in 1965-1995 identified through the Swedish Cancer Register (SCR). First-degree relatives (FDRs) to the HL patients and their malignancies were then ascertained together with their malignancies through the Multi-Generation Registry and SCR. The HL patient cohort was stratified on the number of FDRs with cancer, and standardised incidence ratios (SIRs) of developing SM were analysed. In the HL cohort, 781 SM were observed 1 year or longer after HL diagnosis. The risk for developing SM increased with the number of FDRs with cancer, SIRs being 2.26, 3.01, and 3.45 with 0, 1, or >= 2 FDRs with cancer, respectively. Hodgkin's lymphoma long-term survivors treated at a young age with a family history of cancer carry an increased risk for developing SM and may represent a subgroup where standardised screening for the most common cancer sites could be offered in a stringent surveillance programme. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1183010
- author
- Andersson, A ; Enblad, G ; Tavelin, B ; Bjorkholm, M ; Linderoth, Johan LU ; Lagerlof, I ; Merup, M ; Sender, M and Malmer, B
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cohort, second malignancy, late effect, radiotherapy
- in
- British Journal of Cancer
- volume
- 98
- issue
- 5
- pages
- 1001 - 1005
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000254529000022
- scopus:40349091476
- pmid:18268493
- ISSN
- 1532-1827
- DOI
- 10.1038/sj.bjc.6604244
- language
- English
- LU publication?
- yes
- id
- a6d2a090-ea68-4af2-a7f9-d4bb40177b6b (old id 1183010)
- date added to LUP
- 2016-04-01 11:53:48
- date last changed
- 2022-03-13 02:17:37
@article{a6d2a090-ea68-4af2-a7f9-d4bb40177b6b,
abstract = {{This study estimated the risk of second primary malignancies after Hodgkin's lymphoma (HL) in relation to family history of cancer, age at diagnosis and latency, among 6946 patients treated for HL in Sweden in 1965-1995 identified through the Swedish Cancer Register (SCR). First-degree relatives (FDRs) to the HL patients and their malignancies were then ascertained together with their malignancies through the Multi-Generation Registry and SCR. The HL patient cohort was stratified on the number of FDRs with cancer, and standardised incidence ratios (SIRs) of developing SM were analysed. In the HL cohort, 781 SM were observed 1 year or longer after HL diagnosis. The risk for developing SM increased with the number of FDRs with cancer, SIRs being 2.26, 3.01, and 3.45 with 0, 1, or >= 2 FDRs with cancer, respectively. Hodgkin's lymphoma long-term survivors treated at a young age with a family history of cancer carry an increased risk for developing SM and may represent a subgroup where standardised screening for the most common cancer sites could be offered in a stringent surveillance programme.}},
author = {{Andersson, A and Enblad, G and Tavelin, B and Bjorkholm, M and Linderoth, Johan and Lagerlof, I and Merup, M and Sender, M and Malmer, B}},
issn = {{1532-1827}},
keywords = {{cohort; second malignancy; late effect; radiotherapy}},
language = {{eng}},
number = {{5}},
pages = {{1001--1005}},
publisher = {{Nature Publishing Group}},
series = {{British Journal of Cancer}},
title = {{Family history of cancer as a risk factor for second malignancies after Hodgkin's lymphoma}},
url = {{http://dx.doi.org/10.1038/sj.bjc.6604244}},
doi = {{10.1038/sj.bjc.6604244}},
volume = {{98}},
year = {{2008}},
}