An extract of Uncaria tomentosa inhibiting cell division and NF-kappaB activity without inducing cell death.
(2003) In International Immunopharmacology 3(13-14). p.1889-1900- Abstract
- Previous reports have demonstrated that extracts of the plant Uncaria tomentosa inhibit tumor cell proliferation and inflammatory responses. We have confirmed that C-Med 100®, a hot water extract of this plant, inhibits tumor cell proliferation albeit with variable efficiency. We extend these findings by showing that this extract also inhibits proliferation of normal mouse T and B lymphocytes and that the inhibition is not caused by toxicity or by induction of apoptosis. Further, the extract did not interfere with IL-2 production nor IL-2 receptor signaling. Since there was no discrete cell cycle block in C-Med 100®-treated cells, we propose that retarded cell cycle progression caused the inhibition of proliferation. Collectively, these... (More)
- Previous reports have demonstrated that extracts of the plant Uncaria tomentosa inhibit tumor cell proliferation and inflammatory responses. We have confirmed that C-Med 100®, a hot water extract of this plant, inhibits tumor cell proliferation albeit with variable efficiency. We extend these findings by showing that this extract also inhibits proliferation of normal mouse T and B lymphocytes and that the inhibition is not caused by toxicity or by induction of apoptosis. Further, the extract did not interfere with IL-2 production nor IL-2 receptor signaling. Since there was no discrete cell cycle block in C-Med 100®-treated cells, we propose that retarded cell cycle progression caused the inhibition of proliferation. Collectively, these data suggested interference with a common pathway controlling cell growth and cell cycle progression. Indeed, we provide direct evidence that C-Med 100® inhibits nuclear factor κB (NF-κB) activity and propose that this at least partially causes the inhibition of proliferation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/118656
- author
- Silver, Christina LU ; Lindgren, Hanna LU ; Pero, Ronald LU ; Leanderson, Tomas LU and Ivars, Fredrik LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Inhibition, NF-κB, Uncaria tomentosa, Proliferation, Apoptosis
- in
- International Immunopharmacology
- volume
- 3
- issue
- 13-14
- pages
- 1889 - 1900
- publisher
- Elsevier
- external identifiers
-
- wos:000187038600017
- pmid:14636838
- scopus:0242580038
- pmid:14636838
- ISSN
- 1878-1705
- DOI
- 10.1016/j.intimp.2003.07.001
- language
- English
- LU publication?
- yes
- id
- 18723ac9-ff7c-4e75-9755-e56a786d50c2 (old id 118656)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14636838&dopt=Abstract
- date added to LUP
- 2016-04-01 12:02:55
- date last changed
- 2022-01-26 22:01:52
@article{18723ac9-ff7c-4e75-9755-e56a786d50c2, abstract = {{Previous reports have demonstrated that extracts of the plant Uncaria tomentosa inhibit tumor cell proliferation and inflammatory responses. We have confirmed that C-Med 100®, a hot water extract of this plant, inhibits tumor cell proliferation albeit with variable efficiency. We extend these findings by showing that this extract also inhibits proliferation of normal mouse T and B lymphocytes and that the inhibition is not caused by toxicity or by induction of apoptosis. Further, the extract did not interfere with IL-2 production nor IL-2 receptor signaling. Since there was no discrete cell cycle block in C-Med 100®-treated cells, we propose that retarded cell cycle progression caused the inhibition of proliferation. Collectively, these data suggested interference with a common pathway controlling cell growth and cell cycle progression. Indeed, we provide direct evidence that C-Med 100® inhibits nuclear factor κB (NF-κB) activity and propose that this at least partially causes the inhibition of proliferation.}}, author = {{Silver, Christina and Lindgren, Hanna and Pero, Ronald and Leanderson, Tomas and Ivars, Fredrik}}, issn = {{1878-1705}}, keywords = {{Inhibition; NF-κB; Uncaria tomentosa; Proliferation; Apoptosis}}, language = {{eng}}, number = {{13-14}}, pages = {{1889--1900}}, publisher = {{Elsevier}}, series = {{International Immunopharmacology}}, title = {{An extract of Uncaria tomentosa inhibiting cell division and NF-kappaB activity without inducing cell death.}}, url = {{http://dx.doi.org/10.1016/j.intimp.2003.07.001}}, doi = {{10.1016/j.intimp.2003.07.001}}, volume = {{3}}, year = {{2003}}, }