Oligoclonal IgG bands synthesized in the central nervous system are present in rats with experimental autoimmune encephalomyelitis.
Roström, Björn LU ; Grubb, Anders LU
and Holmdahl, Rikard
LU
(2004)
In Acta Neurologica Scandinavica
109(2).
p.106-112
- Abstract
- Objective: Oligoclonal bands (OBs) in electrophoresis of cerebrospinal fluid (CSF) are present in multiple sclerosis and here is investigated whether these also occur in experimental autoimmune encephalomyelitis (EAE).
Material and methods: Experimental autoimmune encephalomyelitis was induced in 42 DA rats after immunization with rat spinal chord homogenate and the occurrence of OBs were detected by electrophoresis of both sera and CSF. The relationship between disease symptoms, antibody response against myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG) and appearance of OBs was studied.
Results: Development of CSF-specific OB was found to occur, 6 weeks after immunization, in... (More) - Objective: Oligoclonal bands (OBs) in electrophoresis of cerebrospinal fluid (CSF) are present in multiple sclerosis and here is investigated whether these also occur in experimental autoimmune encephalomyelitis (EAE).
Material and methods: Experimental autoimmune encephalomyelitis was induced in 42 DA rats after immunization with rat spinal chord homogenate and the occurrence of OBs were detected by electrophoresis of both sera and CSF. The relationship between disease symptoms, antibody response against myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG) and appearance of OBs was studied.
Results: Development of CSF-specific OB was found to occur, 6 weeks after immunization, in seven of 42 rats. OB was detected in rats with an antibody response against MBP, whereas as a role no such bands were present in rats with an antibody response against MOG. Initially severe disease symptoms were correlated to a concomitant intense oligoclonal antibody response.
Conclusion: Cerebrospinal fluid-specific OB occurs in EAE. It is present in rats with an anti-MBP, but not in rats with an anti-MOG antibody response. A severe disease results in an intense oligoclonal antibody response, which might have an anti-inflammatory effect. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/120332
- author
- Roström, Björn
LU
; Grubb, Anders
LU
and Holmdahl, Rikard
LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Neurologica Scandinavica
- volume
- 109
- issue
- 2
- pages
- 106 - 112
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000187850400005
- pmid:14705972
- scopus:0842329791
- ISSN
- 1600-0404
- DOI
- 10.1034/j.1600-0404.2003.00187.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019), Division of Clinical Chemistry and Pharmacology (013250300)
- id
- 996a7997-09f3-4390-ae05-474b6d50c159 (old id 120332)
- date added to LUP
- 2016-04-01 15:40:41
- date last changed
- 2023-01-04 18:36:21
@article{996a7997-09f3-4390-ae05-474b6d50c159,
abstract = {{Objective: Oligoclonal bands (OBs) in electrophoresis of cerebrospinal fluid (CSF) are present in multiple sclerosis and here is investigated whether these also occur in experimental autoimmune encephalomyelitis (EAE).<br/><br>
<br/><br>
Material and methods: Experimental autoimmune encephalomyelitis was induced in 42 DA rats after immunization with rat spinal chord homogenate and the occurrence of OBs were detected by electrophoresis of both sera and CSF. The relationship between disease symptoms, antibody response against myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG) and appearance of OBs was studied.<br/><br>
<br/><br>
Results: Development of CSF-specific OB was found to occur, 6 weeks after immunization, in seven of 42 rats. OB was detected in rats with an antibody response against MBP, whereas as a role no such bands were present in rats with an antibody response against MOG. Initially severe disease symptoms were correlated to a concomitant intense oligoclonal antibody response.<br/><br>
<br/><br>
Conclusion: Cerebrospinal fluid-specific OB occurs in EAE. It is present in rats with an anti-MBP, but not in rats with an anti-MOG antibody response. A severe disease results in an intense oligoclonal antibody response, which might have an anti-inflammatory effect.}},
author = {{Roström, Björn and Grubb, Anders and Holmdahl, Rikard}},
issn = {{1600-0404}},
language = {{eng}},
number = {{2}},
pages = {{106--112}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Neurologica Scandinavica}},
title = {{Oligoclonal IgG bands synthesized in the central nervous system are present in rats with experimental autoimmune encephalomyelitis.}},
url = {{https://lup.lub.lu.se/search/files/4447157/623942.pdf}},
doi = {{10.1034/j.1600-0404.2003.00187.x}},
volume = {{109}},
year = {{2004}},
}