C6-peptide serology as diagnostic tool in neuroborreliosis
(2008) In APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 116(5). p.393-399- Abstract
- The aim of this study was to evaluate the usefulness of borrelia serology (Quick ELISA C6 Borrelia assay kit) as a diagnostic tool in cases of suspected neuroborreliosis. A retrospective patient material consisting of 124 paired serum and cerebrospinal fluid samples with a positive anti-borrelia antibody index (AI) using the IDEIA Lyme Neuroborreliosis test was compared with 124 Al-negative matched control subjects. The patients were divided into four groups based on presence of pleocytosis and age above or below 12 years. The presence of positive C6 serology in AI-positive patients with pleocytosis was 89% (83/93), significantly different (p < 0.01) from in patients without pleocytosis (58%, 18/31). In AI-positive patients aged >=... (More)
- The aim of this study was to evaluate the usefulness of borrelia serology (Quick ELISA C6 Borrelia assay kit) as a diagnostic tool in cases of suspected neuroborreliosis. A retrospective patient material consisting of 124 paired serum and cerebrospinal fluid samples with a positive anti-borrelia antibody index (AI) using the IDEIA Lyme Neuroborreliosis test was compared with 124 Al-negative matched control subjects. The patients were divided into four groups based on presence of pleocytosis and age above or below 12 years. The presence of positive C6 serology in AI-positive patients with pleocytosis was 89% (83/93), significantly different (p < 0.01) from in patients without pleocytosis (58%, 18/31). In AI-positive patients aged >= 12 years with pleocytosis, 94% (51/54) had a positive C6 serology. Of AI-positive patients with a symptom duration of more than 30 days, 93% (27/29) were positive by the C6 test. We conclude that the C6 serum test, together with clinical evaluation, is a powerful diagnostic tool in adult (>= 12 years) European patients with suspected neuroborreliosis with a symptom duration of more than 30 days. Patients with suspected neuroborreliosis and positive C6 results should be further investigated by lumbar puncture for definite diagnosis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1205391
- author
- Tjernberg, Ivar ; Schon, Thomas ; Ernerudh, Jan ; Wistedt, Annika Carlsson ; Forsberg, Pia and Eliasson, Ingvar LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cerebrospinal fluid, Lyme neuroborreliosis, serology, pleocytosis, intrathecal antibodies
- in
- APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
- volume
- 116
- issue
- 5
- pages
- 393 - 399
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000255490600007
- scopus:43049138377
- pmid:18452429
- ISSN
- 1600-0463
- DOI
- 10.1111/j.1600-0463.2008.00842.x
- language
- English
- LU publication?
- yes
- id
- fc21d756-5721-449a-8b0d-8ce05bf029b3 (old id 1205391)
- date added to LUP
- 2016-04-01 12:26:34
- date last changed
- 2022-01-27 03:49:35
@article{fc21d756-5721-449a-8b0d-8ce05bf029b3, abstract = {{The aim of this study was to evaluate the usefulness of borrelia serology (Quick ELISA C6 Borrelia assay kit) as a diagnostic tool in cases of suspected neuroborreliosis. A retrospective patient material consisting of 124 paired serum and cerebrospinal fluid samples with a positive anti-borrelia antibody index (AI) using the IDEIA Lyme Neuroborreliosis test was compared with 124 Al-negative matched control subjects. The patients were divided into four groups based on presence of pleocytosis and age above or below 12 years. The presence of positive C6 serology in AI-positive patients with pleocytosis was 89% (83/93), significantly different (p < 0.01) from in patients without pleocytosis (58%, 18/31). In AI-positive patients aged >= 12 years with pleocytosis, 94% (51/54) had a positive C6 serology. Of AI-positive patients with a symptom duration of more than 30 days, 93% (27/29) were positive by the C6 test. We conclude that the C6 serum test, together with clinical evaluation, is a powerful diagnostic tool in adult (>= 12 years) European patients with suspected neuroborreliosis with a symptom duration of more than 30 days. Patients with suspected neuroborreliosis and positive C6 results should be further investigated by lumbar puncture for definite diagnosis.}}, author = {{Tjernberg, Ivar and Schon, Thomas and Ernerudh, Jan and Wistedt, Annika Carlsson and Forsberg, Pia and Eliasson, Ingvar}}, issn = {{1600-0463}}, keywords = {{cerebrospinal fluid; Lyme neuroborreliosis; serology; pleocytosis; intrathecal antibodies}}, language = {{eng}}, number = {{5}}, pages = {{393--399}}, publisher = {{John Wiley & Sons Inc.}}, series = {{APMIS : acta pathologica, microbiologica, et immunologica Scandinavica}}, title = {{C6-peptide serology as diagnostic tool in neuroborreliosis}}, url = {{http://dx.doi.org/10.1111/j.1600-0463.2008.00842.x}}, doi = {{10.1111/j.1600-0463.2008.00842.x}}, volume = {{116}}, year = {{2008}}, }