Five-Year Outcome of Cholinergic Treatment of Alzheimer's Disease: Early Response Predicts Prolonged Time until Nursing Home Placement, but Does Not Alter Life Expectancy.
(2004) In Dementia and Geriatric Cognitive Disorders 18(2). p.197-206- Abstract
- Fifty consecutive outpatients with Alzheimer’s disease (AD) received treatment with the cholinesterase inhibitor tacrine in an open longitudinal study. Assessments using Mini-Mental State Examination, Alzheimer’s Disease Assessment Scale – cognitive subscale, and a global rating were made at baseline and at 6, 12, 24, 36, 48 and 60 months. Three outcome groups were characterized: responders, unchanged and deteriorated. Additional outcome measures were time until nursing home placement, and mortality rate. At 6 months –75%, at 12 months –42%, at 24 months –20%, and after that 10% of the patients still on medication had improved or remained stable. The mortality rate did not differ between the outcome groups. Response to tacrine treatment at... (More)
- Fifty consecutive outpatients with Alzheimer’s disease (AD) received treatment with the cholinesterase inhibitor tacrine in an open longitudinal study. Assessments using Mini-Mental State Examination, Alzheimer’s Disease Assessment Scale – cognitive subscale, and a global rating were made at baseline and at 6, 12, 24, 36, 48 and 60 months. Three outcome groups were characterized: responders, unchanged and deteriorated. Additional outcome measures were time until nursing home placement, and mortality rate. At 6 months –75%, at 12 months –42%, at 24 months –20%, and after that 10% of the patients still on medication had improved or remained stable. The mortality rate did not differ between the outcome groups. Response to tacrine treatment at 6 or 12 months was found to predict a prolonged time until nursing home placement. No predictors for a positive treatment response could be identified at baseline. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/123981
- author
- Wallin, Åsa LU ; Gustafson, Lars LU ; Sjögren, Magnus ; Wattmo, Carina LU and Minthon, Lennart LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Long-term treatment, Tacrine, Alzheimer's disease, Nursing home placement.
- in
- Dementia and Geriatric Cognitive Disorders
- volume
- 18
- issue
- 2
- pages
- 197 - 206
- publisher
- Karger
- external identifiers
-
- wos:000223321800013
- pmid:15211076
- scopus:4344675187
- ISSN
- 1420-8008
- DOI
- 10.1159/000079201
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Clinical Sciences, Malmö (013240000), Clinical Memory Research Unit (013242610), Department of Psychogeriatrics (013304000)
- id
- b3dd9b56-aa3d-4920-81fb-215fbf7f4d30 (old id 123981)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15211076&dopt=Abstract
- http://www.karger.com/Article/FullText/79201
- date added to LUP
- 2016-04-01 12:10:13
- date last changed
- 2022-01-26 23:47:31
@article{b3dd9b56-aa3d-4920-81fb-215fbf7f4d30,
abstract = {{Fifty consecutive outpatients with Alzheimer’s disease (AD) received treatment with the cholinesterase inhibitor tacrine in an open longitudinal study. Assessments using Mini-Mental State Examination, Alzheimer’s Disease Assessment Scale – cognitive subscale, and a global rating were made at baseline and at 6, 12, 24, 36, 48 and 60 months. Three outcome groups were characterized: responders, unchanged and deteriorated. Additional outcome measures were time until nursing home placement, and mortality rate. At 6 months –75%, at 12 months –42%, at 24 months –20%, and after that 10% of the patients still on medication had improved or remained stable. The mortality rate did not differ between the outcome groups. Response to tacrine treatment at 6 or 12 months was found to predict a prolonged time until nursing home placement. No predictors for a positive treatment response could be identified at baseline.}},
author = {{Wallin, Åsa and Gustafson, Lars and Sjögren, Magnus and Wattmo, Carina and Minthon, Lennart}},
issn = {{1420-8008}},
keywords = {{Long-term treatment; Tacrine; Alzheimer's disease; Nursing home placement.}},
language = {{eng}},
number = {{2}},
pages = {{197--206}},
publisher = {{Karger}},
series = {{Dementia and Geriatric Cognitive Disorders}},
title = {{Five-Year Outcome of Cholinergic Treatment of Alzheimer's Disease: Early Response Predicts Prolonged Time until Nursing Home Placement, but Does Not Alter Life Expectancy.}},
url = {{http://dx.doi.org/10.1159/000079201}},
doi = {{10.1159/000079201}},
volume = {{18}},
year = {{2004}},
}