No evidence for new dopaminergic neurons in the adult mammalian substantia nigra.
(2004) In Proceedings of the National Academy of Sciences 101(27). p.10177-10182- Abstract
- A recent report by Zhao et al. [Zhao, M., Momma, S., Delfani, K., Carlen, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisen, J. & Janson, A. M. (2003) Proc. Natl. Acad. Sci. USA 100, 7925–7930] suggests that dopaminergic neurons, the cell type lost in Parkinson's disease, are continuously generated in the adult substantia nigra pars compacta. Using similar methodological procedures to label dividing cells, we found no evidence of new dopaminergic neurons in the substantia nigra, either in normal or 6-hydroxydopamine-lesioned hemi-Parkinsonian rodents, or even after growth factor treatment. Furthermore, we found no evidence of neural stem cells emanating from the cerebroventricular system and migrating to the... (More)
- A recent report by Zhao et al. [Zhao, M., Momma, S., Delfani, K., Carlen, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisen, J. & Janson, A. M. (2003) Proc. Natl. Acad. Sci. USA 100, 7925–7930] suggests that dopaminergic neurons, the cell type lost in Parkinson's disease, are continuously generated in the adult substantia nigra pars compacta. Using similar methodological procedures to label dividing cells, we found no evidence of new dopaminergic neurons in the substantia nigra, either in normal or 6-hydroxydopamine-lesioned hemi-Parkinsonian rodents, or even after growth factor treatment. Furthermore, we found no evidence of neural stem cells emanating from the cerebroventricular system and migrating to the substantia nigra. We conclude that it is unlikely that dopaminergic neurons are generated in the adult mammalian substantia nigra. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/123993
- author
- Frielingsdorf, Helena LU ; Schwarz, Katherine ; Brundin, Patrik LU and Mohapel, Paul LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Proceedings of the National Academy of Sciences
- volume
- 101
- issue
- 27
- pages
- 10177 - 10182
- publisher
- National Academy of Sciences
- external identifiers
-
- wos:000222534200043
- scopus:3042829625
- pmid:15210991
- ISSN
- 1091-6490
- DOI
- 10.1073/pnas.0401229101
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Wallenberg Neuroscience Centre, Lund (0131000110)
- id
- 9a1e8230-bad0-4a95-98e7-b9c81f6959a7 (old id 123993)
- date added to LUP
- 2016-04-01 11:33:28
- date last changed
- 2022-01-26 07:03:38
@article{9a1e8230-bad0-4a95-98e7-b9c81f6959a7, abstract = {{A recent report by Zhao et al. [Zhao, M., Momma, S., Delfani, K., Carlen, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisen, J. & Janson, A. M. (2003) Proc. Natl. Acad. Sci. USA 100, 7925–7930] suggests that dopaminergic neurons, the cell type lost in Parkinson's disease, are continuously generated in the adult substantia nigra pars compacta. Using similar methodological procedures to label dividing cells, we found no evidence of new dopaminergic neurons in the substantia nigra, either in normal or 6-hydroxydopamine-lesioned hemi-Parkinsonian rodents, or even after growth factor treatment. Furthermore, we found no evidence of neural stem cells emanating from the cerebroventricular system and migrating to the substantia nigra. We conclude that it is unlikely that dopaminergic neurons are generated in the adult mammalian substantia nigra.}}, author = {{Frielingsdorf, Helena and Schwarz, Katherine and Brundin, Patrik and Mohapel, Paul}}, issn = {{1091-6490}}, language = {{eng}}, number = {{27}}, pages = {{10177--10182}}, publisher = {{National Academy of Sciences}}, series = {{Proceedings of the National Academy of Sciences}}, title = {{No evidence for new dopaminergic neurons in the adult mammalian substantia nigra.}}, url = {{http://dx.doi.org/10.1073/pnas.0401229101}}, doi = {{10.1073/pnas.0401229101}}, volume = {{101}}, year = {{2004}}, }