Deep brain stimulation in Parkinson's disease following fetal nigral transplantation
(2008) In Movement Disorders 23(9). p.1293-1296- Abstract
- OFF-period dyskinesias have been reported as a consequence of fetal nigral transplantation for Parkinson's disease. This type of dyskinesias may appear in patients even in the prolonged absence of antiparkinson medication and be aggravated by levodopa. Therefore, pharmacological therapeutic approaches in these patients are limited. Here we report two patients with bilateral fetal nigral grafts in the caudate and putamen subjected to deep brain stimulation (DBS) of the globus pallidus internus (GPi) or subthalamic nucleus (STN). Clinical assessment was performed according to UPDRS and the clinical dyskinesia rating scale. In both patients, we found significant improvement in OFF-period symptoms as well as levodopa-induced dyskinesias.... (More)
- OFF-period dyskinesias have been reported as a consequence of fetal nigral transplantation for Parkinson's disease. This type of dyskinesias may appear in patients even in the prolonged absence of antiparkinson medication and be aggravated by levodopa. Therefore, pharmacological therapeutic approaches in these patients are limited. Here we report two patients with bilateral fetal nigral grafts in the caudate and putamen subjected to deep brain stimulation (DBS) of the globus pallidus internus (GPi) or subthalamic nucleus (STN). Clinical assessment was performed according to UPDRS and the clinical dyskinesia rating scale. In both patients, we found significant improvement in OFF-period symptoms as well as levodopa-induced dyskinesias. However, only GPi-DBS led to a significant reduction of OFF-period dyskinesias whereas STN-DBS did not influence dyskinesias unrelated to external dopaminergic application. These findings, based on two case reports, highlight the pivotal role of the GPi in mediating dyskinesia-related neural activity within the basal ganglia loop. (C) 2008 Movement Disorder Society. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1252738
- author
- Herzog, Jan ; Pogarell, Oliver ; Pinsker, Marcus O. ; Kupsch, Andreas ; Oertel, Wolfgang H. ; Lindvall, Olle LU ; Deuschl, Guenther and Volkmann, Jens
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- deep brain stimulation, Parkinson's disease, neural transplantation, dyskinesias
- in
- Movement Disorders
- volume
- 23
- issue
- 9
- pages
- 1293 - 1296
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000258421800016
- scopus:52649157756
- ISSN
- 0885-3185
- DOI
- 10.1002/mds.21768
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Restorative Neurology (0131000160)
- id
- 24d34b73-cb9e-4208-a4c2-a2d1351ae092 (old id 1252738)
- date added to LUP
- 2016-04-01 12:25:01
- date last changed
- 2022-03-13 17:38:25
@article{24d34b73-cb9e-4208-a4c2-a2d1351ae092, abstract = {{OFF-period dyskinesias have been reported as a consequence of fetal nigral transplantation for Parkinson's disease. This type of dyskinesias may appear in patients even in the prolonged absence of antiparkinson medication and be aggravated by levodopa. Therefore, pharmacological therapeutic approaches in these patients are limited. Here we report two patients with bilateral fetal nigral grafts in the caudate and putamen subjected to deep brain stimulation (DBS) of the globus pallidus internus (GPi) or subthalamic nucleus (STN). Clinical assessment was performed according to UPDRS and the clinical dyskinesia rating scale. In both patients, we found significant improvement in OFF-period symptoms as well as levodopa-induced dyskinesias. However, only GPi-DBS led to a significant reduction of OFF-period dyskinesias whereas STN-DBS did not influence dyskinesias unrelated to external dopaminergic application. These findings, based on two case reports, highlight the pivotal role of the GPi in mediating dyskinesia-related neural activity within the basal ganglia loop. (C) 2008 Movement Disorder Society.}}, author = {{Herzog, Jan and Pogarell, Oliver and Pinsker, Marcus O. and Kupsch, Andreas and Oertel, Wolfgang H. and Lindvall, Olle and Deuschl, Guenther and Volkmann, Jens}}, issn = {{0885-3185}}, keywords = {{deep brain stimulation; Parkinson's disease; neural transplantation; dyskinesias}}, language = {{eng}}, number = {{9}}, pages = {{1293--1296}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Movement Disorders}}, title = {{Deep brain stimulation in Parkinson's disease following fetal nigral transplantation}}, url = {{http://dx.doi.org/10.1002/mds.21768}}, doi = {{10.1002/mds.21768}}, volume = {{23}}, year = {{2008}}, }