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Effect of Dynamic Channelling on the Transient-state Kinetics of Coupled Enzyme Reactions

Pettersson, Gösta LU (1999) In Journal of Theoretical Biology 198(1). p.135-141
Abstract
Evidence is presented to show that the presence of a channelled reaction branch in a coupled two-enzyme reaction leads to a slower overall relaxation of the system towards steady state following perturbations of the reaction conditions. A predominant part of the total reaction flux change resulting from perturbations may be governed by transients that are more rapid in the presence than in the absence of a channel, but only under specific conditions that are not likely to be of biological relevance.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Theoretical Biology
volume
198
issue
1
pages
135 - 141
publisher
Academic Press
external identifiers
  • scopus:0033532136
ISSN
1095-8541
DOI
10.1006/jtbi.1999.0904
language
English
LU publication?
yes
id
34ab10a3-472c-433e-9a34-e17509f0809b (old id 125393)
date added to LUP
2016-04-01 15:25:23
date last changed
2022-01-28 05:16:10
@article{34ab10a3-472c-433e-9a34-e17509f0809b,
  abstract     = {{Evidence is presented to show that the presence of a channelled reaction branch in a coupled two-enzyme reaction leads to a slower overall relaxation of the system towards steady state following perturbations of the reaction conditions. A predominant part of the total reaction flux change resulting from perturbations may be governed by transients that are more rapid in the presence than in the absence of a channel, but only under specific conditions that are not likely to be of biological relevance.}},
  author       = {{Pettersson, Gösta}},
  issn         = {{1095-8541}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{135--141}},
  publisher    = {{Academic Press}},
  series       = {{Journal of Theoretical Biology}},
  title        = {{Effect of Dynamic Channelling on the Transient-state Kinetics of Coupled Enzyme Reactions}},
  url          = {{http://dx.doi.org/10.1006/jtbi.1999.0904}},
  doi          = {{10.1006/jtbi.1999.0904}},
  volume       = {{198}},
  year         = {{1999}},
}