CCL25/CCR9 promotes the induction and function of CD103 on intestinal intraepithelial lymphocytes.
(2004) In European Journal of Immunology 34(10). p.2720-2729- Abstract
- The integrin CD103 and the chemokine receptor CCR9 are co-expressed on small intestinal CD8+ intraepithelial lymphocytes (IEL), naïve murine CD8+ T cells and by a small population of effector/memory CD8+ T cells, indicating a potential role for CCR9 in regulating CD103 expression and function. Here, we demonstrate that CD103, in contrast to CCR9, is down-regulated on CD8+ T cells following their activation in mesenteric lymph nodes and that effector CD8+ T cells upon initial entry into the small intestinal epithelium are CCR9+CD103-. CD103 was rapidly induced on wild-type CD8+ T cells subsequent to their entry into the small intestinal epithelium, however, CCR9-/- CD8+ T cells exhibited a significant delay in CD103 induction at this site.... (More)
- The integrin CD103 and the chemokine receptor CCR9 are co-expressed on small intestinal CD8+ intraepithelial lymphocytes (IEL), naïve murine CD8+ T cells and by a small population of effector/memory CD8+ T cells, indicating a potential role for CCR9 in regulating CD103 expression and function. Here, we demonstrate that CD103, in contrast to CCR9, is down-regulated on CD8+ T cells following their activation in mesenteric lymph nodes and that effector CD8+ T cells upon initial entry into the small intestinal epithelium are CCR9+CD103-. CD103 was rapidly induced on wild-type CD8+ T cells subsequent to their entry into the small intestinal epithelium, however, CCR9-/- CD8+ T cells exhibited a significant delay in CD103 induction at this site. In addition, the CCR9 ligand, CCL25, that is constitutively expressed in the small intestinal epithelium, induced transient, dose-dependent and pertussis toxin-sensitive CD103-mediated adhesion of CD8+ small intestinal IEL to a murine E-cadherin human Fc (mEFc) fusion protein. Together, these results demonstrate a role for CCR9/CCL25 in promoting the induction and function of CD103 on CD8+ IEL and suggest that this chemokine receptor/chemokine pair may function to regulate lymphocyte-epithelial interactions in the small intestinal mucosa. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/127383
- author
- Ericsson, Anna LU ; Svensson Frej, Marcus LU ; Arya, Anu and Agace, William LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- T lymphocyte, Chemokine, Integrin, Adhesion, Epithelium
- in
- European Journal of Immunology
- volume
- 34
- issue
- 10
- pages
- 2720 - 2729
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000224517800011
- pmid:15368288
- scopus:7244248660
- ISSN
- 1521-4141
- DOI
- 10.1002/eji.200425125
- language
- English
- LU publication?
- yes
- id
- f78779a7-4e6a-467a-8c42-e052e20aa940 (old id 127383)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15368288&dopt=Abstract
- date added to LUP
- 2016-04-01 11:38:13
- date last changed
- 2022-01-26 07:59:55
@article{f78779a7-4e6a-467a-8c42-e052e20aa940, abstract = {{The integrin CD103 and the chemokine receptor CCR9 are co-expressed on small intestinal CD8+ intraepithelial lymphocytes (IEL), naïve murine CD8+ T cells and by a small population of effector/memory CD8+ T cells, indicating a potential role for CCR9 in regulating CD103 expression and function. Here, we demonstrate that CD103, in contrast to CCR9, is down-regulated on CD8+ T cells following their activation in mesenteric lymph nodes and that effector CD8+ T cells upon initial entry into the small intestinal epithelium are CCR9+CD103-. CD103 was rapidly induced on wild-type CD8+ T cells subsequent to their entry into the small intestinal epithelium, however, CCR9-/- CD8+ T cells exhibited a significant delay in CD103 induction at this site. In addition, the CCR9 ligand, CCL25, that is constitutively expressed in the small intestinal epithelium, induced transient, dose-dependent and pertussis toxin-sensitive CD103-mediated adhesion of CD8+ small intestinal IEL to a murine E-cadherin human Fc (mEFc) fusion protein. Together, these results demonstrate a role for CCR9/CCL25 in promoting the induction and function of CD103 on CD8+ IEL and suggest that this chemokine receptor/chemokine pair may function to regulate lymphocyte-epithelial interactions in the small intestinal mucosa.}}, author = {{Ericsson, Anna and Svensson Frej, Marcus and Arya, Anu and Agace, William}}, issn = {{1521-4141}}, keywords = {{T lymphocyte; Chemokine; Integrin; Adhesion; Epithelium}}, language = {{eng}}, number = {{10}}, pages = {{2720--2729}}, publisher = {{John Wiley & Sons Inc.}}, series = {{European Journal of Immunology}}, title = {{CCL25/CCR9 promotes the induction and function of CD103 on intestinal intraepithelial lymphocytes.}}, url = {{http://dx.doi.org/10.1002/eji.200425125}}, doi = {{10.1002/eji.200425125}}, volume = {{34}}, year = {{2004}}, }