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A galabiose-based two-dimensional scaffold for the synthesis of inhibitors targeting Pk- and P-antigen binding proteins.

Ohlsson, Jörgen LU and Nilsson, Ulf LU (2003) In Tetrahedron Letters 44(14). p.2785-2787
Abstract
A disaccharide scaffold based on galabiose (Gal1–4Gal) was synthesized. Four different acceptors were evaluated in the -galactosylation and a relationship between the nucleophilicity, yield, and /-selectivity was found. The scaffold contains two orthogonal derivatisation sites, i.e. at O-2′ and the anomeric position, and as proof of concept, one derivatised galabioside was synthesized. Compounds based on this galabiose-scaffold are potential inhibitors of P- and Pk-antigen binding proteins.
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Tetrahedron Letters
volume
44
issue
14
pages
2785 - 2787
publisher
Elsevier
external identifiers
  • wos:000181893800004
  • scopus:0037474663
ISSN
0040-4039
DOI
10.1016/S0040-4039(03)00475-1
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
ab5f9e01-390c-439c-a7de-f0f3d616cbdf (old id 127972)
date added to LUP
2016-04-01 16:59:48
date last changed
2022-01-28 23:39:16
@article{ab5f9e01-390c-439c-a7de-f0f3d616cbdf,
  abstract     = {{A disaccharide scaffold based on galabiose (Gal1–4Gal) was synthesized. Four different acceptors were evaluated in the -galactosylation and a relationship between the nucleophilicity, yield, and /-selectivity was found. The scaffold contains two orthogonal derivatisation sites, i.e. at O-2′ and the anomeric position, and as proof of concept, one derivatised galabioside was synthesized. Compounds based on this galabiose-scaffold are potential inhibitors of P- and Pk-antigen binding proteins.}},
  author       = {{Ohlsson, Jörgen and Nilsson, Ulf}},
  issn         = {{0040-4039}},
  language     = {{eng}},
  number       = {{14}},
  pages        = {{2785--2787}},
  publisher    = {{Elsevier}},
  series       = {{Tetrahedron Letters}},
  title        = {{A galabiose-based two-dimensional scaffold for the synthesis of inhibitors targeting Pk- and P-antigen binding proteins.}},
  url          = {{http://dx.doi.org/10.1016/S0040-4039(03)00475-1}},
  doi          = {{10.1016/S0040-4039(03)00475-1}},
  volume       = {{44}},
  year         = {{2003}},
}