Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles
Yazer, Mark H. ; Hosseini Maaf, Bahram LU and Olsson, Martin L LU
(2008)
In Current Opinion in Hematology
15(6).
p.618-624
- Abstract
- Purpose of review In the modern transfusion service, analysis of the ABO allele underlying a donor or recipient's A or B subtype phenotype is becoming a mainstream adjunct to the serological investigation. Although an analysis of the ABO gene can be helpful in establishing the nature of the subtype phenotype, numerous confounding factors exist that can lead to a discrepancy between the genotype and the observed phenotype. Recent findings Although the most common group O alleles share a common crippling polymorphism, a growing number of alleles feature other polymorphisms that render their protein nonfunctional yet are similar enough to the consensus A allele that an errant phenotype would be predicted from the genotype, if the genotyping... (More)
- Purpose of review In the modern transfusion service, analysis of the ABO allele underlying a donor or recipient's A or B subtype phenotype is becoming a mainstream adjunct to the serological investigation. Although an analysis of the ABO gene can be helpful in establishing the nature of the subtype phenotype, numerous confounding factors exist that can lead to a discrepancy between the genotype and the observed phenotype. Recent findings Although the most common group O alleles share a common crippling polymorphism, a growing number of alleles feature other polymorphisms that render their protein nonfunctional yet are similar enough to the consensus A allele that an errant phenotype would be predicted from the genotype, if the genotyping method was not specifically designed for their detection. Some of these O alleles might actually encode a protein with weak and variable A antigen synthetic ability. Summary ABO genotyping can be a powerful asset in the transfusion service, but a thorough knowledge of the confounding factors that can lead to genotype/phenotype discrepancies is required. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1284758
- author
- Yazer, Mark H.
; Hosseini Maaf, Bahram
LU
and Olsson, Martin L
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- O, nondeletional, genotype, ABO, allele, O-2, phenotype
- in
- Current Opinion in Hematology
- volume
- 15
- issue
- 6
- pages
- 618 - 624
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000260353200011
- scopus:55149091094
- pmid:18832934
- ISSN
- 1531-7048
- DOI
- 10.1097/MOH.0b013e3283127062
- language
- English
- LU publication?
- yes
- id
- a2029fbc-303e-485d-b952-74e73213a198 (old id 1284758)
- date added to LUP
- 2016-04-01 13:18:20
- date last changed
- 2022-04-14 00:24:59
@article{a2029fbc-303e-485d-b952-74e73213a198,
abstract = {{Purpose of review In the modern transfusion service, analysis of the ABO allele underlying a donor or recipient's A or B subtype phenotype is becoming a mainstream adjunct to the serological investigation. Although an analysis of the ABO gene can be helpful in establishing the nature of the subtype phenotype, numerous confounding factors exist that can lead to a discrepancy between the genotype and the observed phenotype. Recent findings Although the most common group O alleles share a common crippling polymorphism, a growing number of alleles feature other polymorphisms that render their protein nonfunctional yet are similar enough to the consensus A allele that an errant phenotype would be predicted from the genotype, if the genotyping method was not specifically designed for their detection. Some of these O alleles might actually encode a protein with weak and variable A antigen synthetic ability. Summary ABO genotyping can be a powerful asset in the transfusion service, but a thorough knowledge of the confounding factors that can lead to genotype/phenotype discrepancies is required.}},
author = {{Yazer, Mark H. and Hosseini Maaf, Bahram and Olsson, Martin L}},
issn = {{1531-7048}},
keywords = {{O; nondeletional; genotype; ABO; allele; O-2; phenotype}},
language = {{eng}},
number = {{6}},
pages = {{618--624}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Current Opinion in Hematology}},
title = {{Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles}},
url = {{http://dx.doi.org/10.1097/MOH.0b013e3283127062}},
doi = {{10.1097/MOH.0b013e3283127062}},
volume = {{15}},
year = {{2008}},
}