CSF levels of tau, beta-amyloid(1-42) and GAP-43 in frontotemporal dementia, other types of dementia and normal aging
(2000) In Journal of Neural Transmission 107(5). p.563-579- Abstract
- Cerebrospinal fluid (CSF) levels of tau, beta-amyloid(1-42) and growth-associated protein 43 (GAP-43) were studied in patients with frontotemporal dementia (FTD; n = 17), Alzheimer's disease (AD; n = 60), subcortical white-matter dementia (SWD; n = 24), Parkinson's disease (PD; n = 23) and dysthymia (n = 19) and in age-matched controls (n = 32). CSF-tau was significantly increased only in AD, and CSF-beta-amyloid(1-42) was significantly decreased in AD and SWD as compared to controls, and in AD compared to FTD. CSF-GAP-43 was significantly decreased only in PD. The GAP-43/tau ratio was decreased in all the patient groups except the dysthymia group compared to controls. A positive correlation was found between CSF-GAP-43 and CSF-tau in all... (More)
- Cerebrospinal fluid (CSF) levels of tau, beta-amyloid(1-42) and growth-associated protein 43 (GAP-43) were studied in patients with frontotemporal dementia (FTD; n = 17), Alzheimer's disease (AD; n = 60), subcortical white-matter dementia (SWD; n = 24), Parkinson's disease (PD; n = 23) and dysthymia (n = 19) and in age-matched controls (n = 32). CSF-tau was significantly increased only in AD, and CSF-beta-amyloid(1-42) was significantly decreased in AD and SWD as compared to controls, and in AD compared to FTD. CSF-GAP-43 was significantly decreased only in PD. The GAP-43/tau ratio was decreased in all the patient groups except the dysthymia group compared to controls. A positive correlation was found between CSF-GAP-43 and CSF-tau in all groups. The results suggest normal levels of CSF-tau and CSF-beta-amyloid(1-42) in FTD, which will aid in the clinical separation of FTD from AD. In SWD, decreased levels of CSF-beta-amyloid(1-42) suggest concomitant involvement of vascular and amyloid protein mechanisms. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1296837
- author
- Sjogren, M ; Minthon, Lennart LU ; Davidsson, P ; Clarberg, A ; Vanderstichele, H ; Vanmechelen, E ; Wallin, A and Blennow, K
- organization
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neural Transmission
- volume
- 107
- issue
- 5
- pages
- 563 - 579
- publisher
- Springer
- external identifiers
-
- wos:000086987900006
- scopus:0034060813
- ISSN
- 0300-9564
- DOI
- 10.1007/s007020070079
- language
- English
- LU publication?
- yes
- id
- 7e39ef77-be7c-4533-a8b8-6301fd542098 (old id 1296837)
- date added to LUP
- 2016-04-01 15:19:50
- date last changed
- 2022-03-14 17:38:55
@article{7e39ef77-be7c-4533-a8b8-6301fd542098, abstract = {{Cerebrospinal fluid (CSF) levels of tau, beta-amyloid(1-42) and growth-associated protein 43 (GAP-43) were studied in patients with frontotemporal dementia (FTD; n = 17), Alzheimer's disease (AD; n = 60), subcortical white-matter dementia (SWD; n = 24), Parkinson's disease (PD; n = 23) and dysthymia (n = 19) and in age-matched controls (n = 32). CSF-tau was significantly increased only in AD, and CSF-beta-amyloid(1-42) was significantly decreased in AD and SWD as compared to controls, and in AD compared to FTD. CSF-GAP-43 was significantly decreased only in PD. The GAP-43/tau ratio was decreased in all the patient groups except the dysthymia group compared to controls. A positive correlation was found between CSF-GAP-43 and CSF-tau in all groups. The results suggest normal levels of CSF-tau and CSF-beta-amyloid(1-42) in FTD, which will aid in the clinical separation of FTD from AD. In SWD, decreased levels of CSF-beta-amyloid(1-42) suggest concomitant involvement of vascular and amyloid protein mechanisms.}}, author = {{Sjogren, M and Minthon, Lennart and Davidsson, P and Clarberg, A and Vanderstichele, H and Vanmechelen, E and Wallin, A and Blennow, K}}, issn = {{0300-9564}}, language = {{eng}}, number = {{5}}, pages = {{563--579}}, publisher = {{Springer}}, series = {{Journal of Neural Transmission}}, title = {{CSF levels of tau, beta-amyloid(1-42) and GAP-43 in frontotemporal dementia, other types of dementia and normal aging}}, url = {{http://dx.doi.org/10.1007/s007020070079}}, doi = {{10.1007/s007020070079}}, volume = {{107}}, year = {{2000}}, }