Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation
(2002) In Science 297(5581). p.573-578- Abstract
- Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/132307
- author
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Science
- volume
- 297
- issue
- 5581
- pages
- 573 - 578
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- wos:000177054200042
- pmid:12142529
- scopus:0037178771
- ISSN
- 1095-9203
- DOI
- 10.1126/science.1069076
- language
- English
- LU publication?
- yes
- id
- 25cbbce1-801e-4548-b5a8-810c4cb0d949 (old id 132307)
- date added to LUP
- 2016-04-01 15:48:09
- date last changed
- 2022-04-22 17:27:44
@article{25cbbce1-801e-4548-b5a8-810c4cb0d949, abstract = {{Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.}}, author = {{Mahdavi, Jafar and Sondén, Berit and Hurtig, Marina and Olfat, Farzad O. and Forsberg, Lina and Roche, Niamh and Ångström, Jonas and Larsson, Thomas and Teneberg, Susann and Karlsson, Karl-Anders and Altraja, Siiri and Wadström, Torkel and Kersulyte, Dangeruta and Berg, Douglas E. and Dubois, Andre and Petersson, Christoffer and Magnusson, Karl-Eric and Norberg, Thomas and Lindh, Frank and Lundskog, Bertil B. and Arnqvist, Anna and Hammarström, Lennart and Borén, Thomas}}, issn = {{1095-9203}}, language = {{eng}}, number = {{5581}}, pages = {{573--578}}, publisher = {{American Association for the Advancement of Science (AAAS)}}, series = {{Science}}, title = {{Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation}}, url = {{https://lup.lub.lu.se/search/files/4476514/624296.pdf}}, doi = {{10.1126/science.1069076}}, volume = {{297}}, year = {{2002}}, }