The function of genomes in bioenergetic organelles.
(2003) In Philosophical Transactions of the Royal Society B: Biological Sciences 358(1429). p.19-37- Abstract
- Mitochondria and chloroplasts are energy-transducing organelles of the cytoplasm of eukaryotic cells. They originated as bacterial symbionts whose host cells acquired respiration from the precursor of the mitochondrion, and oxygenic photosynthesis from the precursor of the chloroplast. The host cells also acquired genetic information from their symbionts, eventually incorporating much of it into their own genomes. Genes of the eukaryotic cell nucleus now encode most mitochondrial and chloroplast proteins. Genes are copied and moved between cellular compartments with relative ease, and there is no obvious obstacle to successful import of any protein precursor from the cytosol. So why are any genes at all retained in cytoplasmic organelles?... (More)
- Mitochondria and chloroplasts are energy-transducing organelles of the cytoplasm of eukaryotic cells. They originated as bacterial symbionts whose host cells acquired respiration from the precursor of the mitochondrion, and oxygenic photosynthesis from the precursor of the chloroplast. The host cells also acquired genetic information from their symbionts, eventually incorporating much of it into their own genomes. Genes of the eukaryotic cell nucleus now encode most mitochondrial and chloroplast proteins. Genes are copied and moved between cellular compartments with relative ease, and there is no obvious obstacle to successful import of any protein precursor from the cytosol. So why are any genes at all retained in cytoplasmic organelles? One proposal is that these small but functional genomes provide a location for genes that is close to, and in the same compartment as, their gene products. This co-location facilitates rapid and direct regulatory coupling. Redox control of synthesis de novo is put forward as the common property of those proteins that must be encoded and synthesized within mitochondria and chloroplasts. This testable hypothesis is termed CORR, for co-location for redox regulation. Principles, predictions and consequences of CORR are examined in the context of competing hypotheses and current evidence. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/132653
- author
- Allen, John LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Philosophical Transactions of the Royal Society B: Biological Sciences
- volume
- 358
- issue
- 1429
- pages
- 19 - 37
- publisher
- Royal Society Publishing
- external identifiers
-
- pmid:12594916
- wos:000180920100004
- scopus:0037471674
- ISSN
- 1471-2970
- DOI
- 10.1098/rstb.2002.1191
- language
- English
- LU publication?
- yes
- id
- e3cc7d70-4f54-43a9-b37b-2e5c124331fa (old id 132653)
- date added to LUP
- 2016-04-01 16:38:53
- date last changed
- 2022-02-20 07:32:30
@article{e3cc7d70-4f54-43a9-b37b-2e5c124331fa,
abstract = {{Mitochondria and chloroplasts are energy-transducing organelles of the cytoplasm of eukaryotic cells. They originated as bacterial symbionts whose host cells acquired respiration from the precursor of the mitochondrion, and oxygenic photosynthesis from the precursor of the chloroplast. The host cells also acquired genetic information from their symbionts, eventually incorporating much of it into their own genomes. Genes of the eukaryotic cell nucleus now encode most mitochondrial and chloroplast proteins. Genes are copied and moved between cellular compartments with relative ease, and there is no obvious obstacle to successful import of any protein precursor from the cytosol. So why are any genes at all retained in cytoplasmic organelles? One proposal is that these small but functional genomes provide a location for genes that is close to, and in the same compartment as, their gene products. This co-location facilitates rapid and direct regulatory coupling. Redox control of synthesis de novo is put forward as the common property of those proteins that must be encoded and synthesized within mitochondria and chloroplasts. This testable hypothesis is termed CORR, for co-location for redox regulation. Principles, predictions and consequences of CORR are examined in the context of competing hypotheses and current evidence.}},
author = {{Allen, John}},
issn = {{1471-2970}},
language = {{eng}},
number = {{1429}},
pages = {{19--37}},
publisher = {{Royal Society Publishing}},
series = {{Philosophical Transactions of the Royal Society B: Biological Sciences}},
title = {{The function of genomes in bioenergetic organelles.}},
url = {{https://lup.lub.lu.se/search/files/4734638/624328.pdf}},
doi = {{10.1098/rstb.2002.1191}},
volume = {{358}},
year = {{2003}},
}