Hypothyroidism Is Common in Turner Syndrome: Results of a Five-Year Follow-Up
(2005) In Journal of Clinical Endocrinology and Metabolism 90(4). p.2131-2135- Abstract
- Turner syndrome (TS) is caused by a sex chromosome aberration. The aim was to study the prevalence and incidence of thyroid disease in adults with TS. Women with TS (n = 91; mean age, 37.7 +/- 11 yr) were compared with an age-matched female random population sample (n = 228). At baseline, 15 (16%) TS women were treated for hypothyroidism, and elevated serum TSH was found in another eight (9%). As a result, hypothyroidism was more common in women with TS (25%) than in controls (2%; P < 0.0001). Serum free T-4 was lower (P = 0.02), and serum TSH was higher (P < 0.0001) in TS women than in age-matched controls. Of all TS women with hypothyroidism, 10 (43%) had an elevated thyroid peroxidase antibody titer vs. 15 (22%) of those without... (More)
- Turner syndrome (TS) is caused by a sex chromosome aberration. The aim was to study the prevalence and incidence of thyroid disease in adults with TS. Women with TS (n = 91; mean age, 37.7 +/- 11 yr) were compared with an age-matched female random population sample (n = 228). At baseline, 15 (16%) TS women were treated for hypothyroidism, and elevated serum TSH was found in another eight (9%). As a result, hypothyroidism was more common in women with TS (25%) than in controls (2%; P < 0.0001). Serum free T-4 was lower (P = 0.02), and serum TSH was higher (P < 0.0001) in TS women than in age-matched controls. Of all TS women with hypothyroidism, 10 (43%) had an elevated thyroid peroxidase antibody titer vs. 15 (22%) of those without hypothyroidism (P < 0.05), evenly distributed between the karyotype 45, X and mosaicism. A high body mass index, but not a family history or blood lipids, was associated with hypothyroidism in TS. After the 5-yr follow-up, an additional 11 (16%) developed hypothyroidism, of whom four (36%) had elevated thyroid peroxidase. Altogether, 34 (37%) TS women had hypothyroidism after the 5-yr follow-up. Autoimmune hypothyroidism was common, with an annual incidence of 3.2% in TS. Thyroid function should be checked regularly in TS. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/133384
- author
- El Masnaouy, Mostafa ; Bryman, Inger ; Berntorp, Kerstin LU ; Hanson, Charles ; Wilhelmsen, Lars and Landin-Wilhelmsen, Kerstin
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Endocrinology and Metabolism
- volume
- 90
- issue
- 4
- pages
- 2131 - 2135
- publisher
- Oxford University Press
- external identifiers
-
- pmid:15623818
- wos:000228198900034
- scopus:19044377827
- ISSN
- 1945-7197
- DOI
- 10.1210/jc.2004-1262
- language
- English
- LU publication?
- yes
- id
- 7463a984-86fa-4ea1-9db7-a674dddb3029 (old id 133384)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15623818&dopt=Abstract
- date added to LUP
- 2016-04-01 15:50:47
- date last changed
- 2024-02-26 08:28:16
@article{7463a984-86fa-4ea1-9db7-a674dddb3029, abstract = {{Turner syndrome (TS) is caused by a sex chromosome aberration. The aim was to study the prevalence and incidence of thyroid disease in adults with TS. Women with TS (n = 91; mean age, 37.7 +/- 11 yr) were compared with an age-matched female random population sample (n = 228). At baseline, 15 (16%) TS women were treated for hypothyroidism, and elevated serum TSH was found in another eight (9%). As a result, hypothyroidism was more common in women with TS (25%) than in controls (2%; P < 0.0001). Serum free T-4 was lower (P = 0.02), and serum TSH was higher (P < 0.0001) in TS women than in age-matched controls. Of all TS women with hypothyroidism, 10 (43%) had an elevated thyroid peroxidase antibody titer vs. 15 (22%) of those without hypothyroidism (P < 0.05), evenly distributed between the karyotype 45, X and mosaicism. A high body mass index, but not a family history or blood lipids, was associated with hypothyroidism in TS. After the 5-yr follow-up, an additional 11 (16%) developed hypothyroidism, of whom four (36%) had elevated thyroid peroxidase. Altogether, 34 (37%) TS women had hypothyroidism after the 5-yr follow-up. Autoimmune hypothyroidism was common, with an annual incidence of 3.2% in TS. Thyroid function should be checked regularly in TS.}}, author = {{El Masnaouy, Mostafa and Bryman, Inger and Berntorp, Kerstin and Hanson, Charles and Wilhelmsen, Lars and Landin-Wilhelmsen, Kerstin}}, issn = {{1945-7197}}, language = {{eng}}, number = {{4}}, pages = {{2131--2135}}, publisher = {{Oxford University Press}}, series = {{Journal of Clinical Endocrinology and Metabolism}}, title = {{Hypothyroidism Is Common in Turner Syndrome: Results of a Five-Year Follow-Up}}, url = {{http://dx.doi.org/10.1210/jc.2004-1262}}, doi = {{10.1210/jc.2004-1262}}, volume = {{90}}, year = {{2005}}, }