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Risk of treatment of peripheral arterial disease is related to inflammation-sensitive plasma proteins : a prospective cohort study

Engström, Gunnar LU ; Site-Flondell, Despina LU ; Lindblad, Bengt LU ; Janzon, Lars LU and Lindgärde, Folke LU (2004) In Journal of Vascular Surgery 40(6). p.1101-1105
Abstract

BACKGROUND: Studies in patients with peripheral arterial disease (PAD) have reported an association between inflammatory markers and severity of disease or worsening of symptoms. However, few have studied the prognostic significance of inflammatory markers in asymptomatic subjects, measured many years before the onset of symptomatic PAD requiring treatment (trPAD).

MATERIAL AND METHODS: Five inflammation-sensitive plasma proteins (ISPs), including fibrinogen, alpha 1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid, were determined in 5619 healthy men (mean age, 46.8 +/- 3.7 years) without walking-induced calf pain. Data for men who subsequently underwent a revascularization procedure because of trPAD (intermittent... (More)

BACKGROUND: Studies in patients with peripheral arterial disease (PAD) have reported an association between inflammatory markers and severity of disease or worsening of symptoms. However, few have studied the prognostic significance of inflammatory markers in asymptomatic subjects, measured many years before the onset of symptomatic PAD requiring treatment (trPAD).

MATERIAL AND METHODS: Five inflammation-sensitive plasma proteins (ISPs), including fibrinogen, alpha 1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid, were determined in 5619 healthy men (mean age, 46.8 +/- 3.7 years) without walking-induced calf pain. Data for men who subsequently underwent a revascularization procedure because of trPAD (intermittent claudication or critical ischemia) were retrieved from hospital-based registers. Future trPAD was studied in relation to the number of ISPs in the top quartile at the baseline examination.

RESULTS: Seventy men (1.2%) underwent revascularization because of trPAD at a mean of 16.5 years after the baseline examination. The proportion with future trPAD was 0.4%, 1.0%, 1.5%, and 3.2%, respectively, for men with 0, 1, 2, and 3 or more ISPs in the top quartile (trend, P < .0001). After adjustment for age, screening year, systolic blood pressure, blood pressure medication, cholesterol concentration, diabetes, smoking, and tobacco consumption the corresponding odds ratios (95% confidence interval [CI]) were 1.00 (reference), 1.5 (CI, 0.7-3.6), 1.9 (CI, 0.8-4.6), and 2.9 (CI, 1.3-6.4), respectively, in these groups (trend, P = .003).

CONCLUSION: Elevated ISPs, measured 16 years earlier in apparently healthy men without walking-induced calf pain, were associated with increased risk for development of PAD requiring revascularization.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Arterial Occlusive Diseases/complications, Biomarkers, Blood Proteins/immunology, Blood Vessel Prosthesis Implantation, Disease Progression, Humans, Intermittent Claudication/immunology, Ischemia/immunology, Leg/blood supply, Male, Middle Aged, Peripheral Vascular Diseases/complications, Predictive Value of Tests, Prognosis, Prospective Studies, Risk Factors, Time Factors
in
Journal of Vascular Surgery
volume
40
issue
6
pages
5 pages
publisher
Mosby-Elsevier
external identifiers
  • wos:000227389300009
  • pmid:15622362
  • scopus:11144328067
  • pmid:15622362
ISSN
1097-6809
DOI
10.1016/j.jvs.2004.09.017
language
English
LU publication?
yes
id
7387d0ae-61c4-4f5f-a4da-0f991cd5866b (old id 133392)
date added to LUP
2016-04-01 17:09:54
date last changed
2024-02-12 07:47:39
@article{7387d0ae-61c4-4f5f-a4da-0f991cd5866b,
  abstract     = {{<p>BACKGROUND: Studies in patients with peripheral arterial disease (PAD) have reported an association between inflammatory markers and severity of disease or worsening of symptoms. However, few have studied the prognostic significance of inflammatory markers in asymptomatic subjects, measured many years before the onset of symptomatic PAD requiring treatment (trPAD).</p><p>MATERIAL AND METHODS: Five inflammation-sensitive plasma proteins (ISPs), including fibrinogen, alpha 1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid, were determined in 5619 healthy men (mean age, 46.8 +/- 3.7 years) without walking-induced calf pain. Data for men who subsequently underwent a revascularization procedure because of trPAD (intermittent claudication or critical ischemia) were retrieved from hospital-based registers. Future trPAD was studied in relation to the number of ISPs in the top quartile at the baseline examination.</p><p>RESULTS: Seventy men (1.2%) underwent revascularization because of trPAD at a mean of 16.5 years after the baseline examination. The proportion with future trPAD was 0.4%, 1.0%, 1.5%, and 3.2%, respectively, for men with 0, 1, 2, and 3 or more ISPs in the top quartile (trend, P &lt; .0001). After adjustment for age, screening year, systolic blood pressure, blood pressure medication, cholesterol concentration, diabetes, smoking, and tobacco consumption the corresponding odds ratios (95% confidence interval [CI]) were 1.00 (reference), 1.5 (CI, 0.7-3.6), 1.9 (CI, 0.8-4.6), and 2.9 (CI, 1.3-6.4), respectively, in these groups (trend, P = .003).</p><p>CONCLUSION: Elevated ISPs, measured 16 years earlier in apparently healthy men without walking-induced calf pain, were associated with increased risk for development of PAD requiring revascularization.</p>}},
  author       = {{Engström, Gunnar and Site-Flondell, Despina and Lindblad, Bengt and Janzon, Lars and Lindgärde, Folke}},
  issn         = {{1097-6809}},
  keywords     = {{Adult; Arterial Occlusive Diseases/complications; Biomarkers; Blood Proteins/immunology; Blood Vessel Prosthesis Implantation; Disease Progression; Humans; Intermittent Claudication/immunology; Ischemia/immunology; Leg/blood supply; Male; Middle Aged; Peripheral Vascular Diseases/complications; Predictive Value of Tests; Prognosis; Prospective Studies; Risk Factors; Time Factors}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1101--1105}},
  publisher    = {{Mosby-Elsevier}},
  series       = {{Journal of Vascular Surgery}},
  title        = {{Risk of treatment of peripheral arterial disease is related to inflammation-sensitive plasma proteins : a prospective cohort study}},
  url          = {{https://lup.lub.lu.se/search/files/4894723/624360.pdf}},
  doi          = {{10.1016/j.jvs.2004.09.017}},
  volume       = {{40}},
  year         = {{2004}},
}