ATP Depletion and Cell Death in the Neonatal Lamb Ductus Arteriosus.
(2005) In Pediatric Research 57(6). p.801-805- Abstract
- Postnatal constriction of the full-term ductus arteriosus produces cell death and remodeling of the ductus wall. Using a bioluminescence imaging technique, we found that after birth, the lamb ductus develops ATP, glucose, and glycogen depletion in addition to hypoxia. In vitro studies showed that cell death correlates best with ATP depletion and is most marked when both glucose and oxygen are severely depleted; in addition, the degree of ATP depletion found in vivo is sufficient to account for the extensive degree of cell death that occurs after birth. Under hypoxic conditions, the immature ductus is more capable of preserving its ATP supply than the mature ductus as a result of increased glucose availability, glycogen stores, and glucose... (More)
- Postnatal constriction of the full-term ductus arteriosus produces cell death and remodeling of the ductus wall. Using a bioluminescence imaging technique, we found that after birth, the lamb ductus develops ATP, glucose, and glycogen depletion in addition to hypoxia. In vitro studies showed that cell death correlates best with ATP depletion and is most marked when both glucose and oxygen are severely depleted; in addition, the degree of ATP depletion found in vivo is sufficient to account for the extensive degree of cell death that occurs after birth. Under hypoxic conditions, the immature ductus is more capable of preserving its ATP supply than the mature ductus as a result of increased glucose availability, glycogen stores, and glucose utilization. However, the immature ductus is just as susceptible as the mature ductus to ATP depletion when glucose supplies are restricted. The extensive degree of cell death that occurs in the newborn ductus after birth is associated primarily with ATP depletion. The increased glycolytic capacity of the immature ductus may enable it to tolerate episodes of hypoxia and nutrient shortage, making it more resistant to developing postnatal cell death and permanent closure. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/134893
- author
- Levin, Max ; Goldbarg, Seth ; Lindqvist, Anders LU ; Swärd, Karl LU ; Roman, Christine ; Liu, Bao Mei ; Hultén, Lillemor Mattsson ; Borén, Jan and Clyman, Ronald I
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Research
- volume
- 57
- issue
- 6
- pages
- 801 - 805
- publisher
- International Pediatric Foundation Inc.
- external identifiers
-
- wos:000229293600010
- pmid:15774827
- scopus:19444379749
- ISSN
- 1530-0447
- DOI
- 10.1203/01.PDR.0000157791.95954.56
- language
- English
- LU publication?
- yes
- id
- 44bf0c9b-a5af-4c4c-94c0-46363f4e5c34 (old id 134893)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15774827&dopt=Abstract
- date added to LUP
- 2016-04-01 12:23:13
- date last changed
- 2022-02-03 21:28:53
@article{44bf0c9b-a5af-4c4c-94c0-46363f4e5c34, abstract = {{Postnatal constriction of the full-term ductus arteriosus produces cell death and remodeling of the ductus wall. Using a bioluminescence imaging technique, we found that after birth, the lamb ductus develops ATP, glucose, and glycogen depletion in addition to hypoxia. In vitro studies showed that cell death correlates best with ATP depletion and is most marked when both glucose and oxygen are severely depleted; in addition, the degree of ATP depletion found in vivo is sufficient to account for the extensive degree of cell death that occurs after birth. Under hypoxic conditions, the immature ductus is more capable of preserving its ATP supply than the mature ductus as a result of increased glucose availability, glycogen stores, and glucose utilization. However, the immature ductus is just as susceptible as the mature ductus to ATP depletion when glucose supplies are restricted. The extensive degree of cell death that occurs in the newborn ductus after birth is associated primarily with ATP depletion. The increased glycolytic capacity of the immature ductus may enable it to tolerate episodes of hypoxia and nutrient shortage, making it more resistant to developing postnatal cell death and permanent closure.}}, author = {{Levin, Max and Goldbarg, Seth and Lindqvist, Anders and Swärd, Karl and Roman, Christine and Liu, Bao Mei and Hultén, Lillemor Mattsson and Borén, Jan and Clyman, Ronald I}}, issn = {{1530-0447}}, language = {{eng}}, number = {{6}}, pages = {{801--805}}, publisher = {{International Pediatric Foundation Inc.}}, series = {{Pediatric Research}}, title = {{ATP Depletion and Cell Death in the Neonatal Lamb Ductus Arteriosus.}}, url = {{http://dx.doi.org/10.1203/01.PDR.0000157791.95954.56}}, doi = {{10.1203/01.PDR.0000157791.95954.56}}, volume = {{57}}, year = {{2005}}, }