A ceramic bone substitute containing gentamicin gives good outcome in trochanteric hip fractures treated with dynamic hip screw and in revision of total hip arthroplasty : A case series
(2018) In BMC Musculoskeletal Disorders 19(1). p.438-438- Abstract
BACKGROUND: The primary objective was to investigate the clinical and radiological outcome in patients undergoing major hip surgery using a novel antibiotic containing bone substitute for local augmentation in trochanteric fracture fixation or revision of total hip arthroplasty (THA).
METHODS: We implanted a novel biphasic bone substitute CERAMENT™|G consisting of hydroxyapatite, calcium sulphate and gentamicin for bone regeneration and local antibiotic delivery in 20 patients treated surgically for trochanteric femoral fracture or uncemented hip revision. Preoperative, postoperative, 3 months and 1 year clinical and radiological assessment were performed including registration of any complications. In one trochanteric fracture... (More)
BACKGROUND: The primary objective was to investigate the clinical and radiological outcome in patients undergoing major hip surgery using a novel antibiotic containing bone substitute for local augmentation in trochanteric fracture fixation or revision of total hip arthroplasty (THA).
METHODS: We implanted a novel biphasic bone substitute CERAMENT™|G consisting of hydroxyapatite, calcium sulphate and gentamicin for bone regeneration and local antibiotic delivery in 20 patients treated surgically for trochanteric femoral fracture or uncemented hip revision. Preoperative, postoperative, 3 months and 1 year clinical and radiological assessment were performed including registration of any complications. In one trochanteric fracture patient, histological analyses were performed of bone biopsies taken at removal of hardware.
RESULTS: None of the trochanteric fractures or revision of THA showed any large migration. No local wound disturbances were seen and no infection was observed at one year follow-up. All trochanteric fractures healed at 3 months with a minimal sliding screw displacement on average 3 mm. Radiological analysis showed signs of bone remodeling and new bone formation in the substitute, illustrated also by histology in the biopsies taken from one trochanteric fracture at one year post-op.
CONCLUSIONS: Local CERAMENT™|G was shown to be safe in a limited prospective major hip surgery study. Remodeling of the bone graft substitute was observed in all patients.
TRIAL REGISTRATION: EU-CTR2018-004414-18 Retrospectively registered on November 20, 2018.
(Less)
- author
- Stravinskas, Mindaugas ; Tarasevicius, Sarunas LU ; Laukaitis, Simonas ; Nilsson, Malin ; Raina, Deepak Bushan LU and Lidgren, Lars LU
- organization
- publishing date
- 2018-12-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aged, Aged, 80 and over, Anti-Bacterial Agents/administration & dosage, Arthroplasty, Replacement, Hip/adverse effects, Bone Remodeling, Bone Screws, Bone Substitutes, Calcium Sulfate, Drug Combinations, Durapatite, Feasibility Studies, Female, Follow-Up Studies, Fracture Fixation, Internal/adverse effects, Gentamicins/administration & dosage, Hip/diagnostic imaging, Hip Fractures/diagnostic imaging, Humans, Male, Middle Aged, Osteogenesis, Postoperative Complications, Prospective Studies, Radiography, Reoperation/adverse effects, Treatment Outcome
- in
- BMC Musculoskeletal Disorders
- volume
- 19
- issue
- 1
- article number
- 438
- pages
- 438 - 438
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:30522476
- scopus:85058074398
- ISSN
- 1471-2474
- DOI
- 10.1186/s12891-018-2360-8
- language
- English
- LU publication?
- yes
- id
- 13743c9e-8afc-4c5e-afdf-16c81e0360ad
- date added to LUP
- 2018-12-18 14:24:01
- date last changed
- 2024-08-20 06:44:04
@article{13743c9e-8afc-4c5e-afdf-16c81e0360ad, abstract = {{<p>BACKGROUND: The primary objective was to investigate the clinical and radiological outcome in patients undergoing major hip surgery using a novel antibiotic containing bone substitute for local augmentation in trochanteric fracture fixation or revision of total hip arthroplasty (THA).</p><p>METHODS: We implanted a novel biphasic bone substitute CERAMENT™|G consisting of hydroxyapatite, calcium sulphate and gentamicin for bone regeneration and local antibiotic delivery in 20 patients treated surgically for trochanteric femoral fracture or uncemented hip revision. Preoperative, postoperative, 3 months and 1 year clinical and radiological assessment were performed including registration of any complications. In one trochanteric fracture patient, histological analyses were performed of bone biopsies taken at removal of hardware.</p><p>RESULTS: None of the trochanteric fractures or revision of THA showed any large migration. No local wound disturbances were seen and no infection was observed at one year follow-up. All trochanteric fractures healed at 3 months with a minimal sliding screw displacement on average 3 mm. Radiological analysis showed signs of bone remodeling and new bone formation in the substitute, illustrated also by histology in the biopsies taken from one trochanteric fracture at one year post-op.</p><p>CONCLUSIONS: Local CERAMENT™|G was shown to be safe in a limited prospective major hip surgery study. Remodeling of the bone graft substitute was observed in all patients.</p><p>TRIAL REGISTRATION: EU-CTR2018-004414-18 Retrospectively registered on November 20, 2018.</p>}}, author = {{Stravinskas, Mindaugas and Tarasevicius, Sarunas and Laukaitis, Simonas and Nilsson, Malin and Raina, Deepak Bushan and Lidgren, Lars}}, issn = {{1471-2474}}, keywords = {{Aged; Aged, 80 and over; Anti-Bacterial Agents/administration & dosage; Arthroplasty, Replacement, Hip/adverse effects; Bone Remodeling; Bone Screws; Bone Substitutes; Calcium Sulfate; Drug Combinations; Durapatite; Feasibility Studies; Female; Follow-Up Studies; Fracture Fixation, Internal/adverse effects; Gentamicins/administration & dosage; Hip/diagnostic imaging; Hip Fractures/diagnostic imaging; Humans; Male; Middle Aged; Osteogenesis; Postoperative Complications; Prospective Studies; Radiography; Reoperation/adverse effects; Treatment Outcome}}, language = {{eng}}, month = {{12}}, number = {{1}}, pages = {{438--438}}, publisher = {{BioMed Central (BMC)}}, series = {{BMC Musculoskeletal Disorders}}, title = {{A ceramic bone substitute containing gentamicin gives good outcome in trochanteric hip fractures treated with dynamic hip screw and in revision of total hip arthroplasty : A case series}}, url = {{http://dx.doi.org/10.1186/s12891-018-2360-8}}, doi = {{10.1186/s12891-018-2360-8}}, volume = {{19}}, year = {{2018}}, }