A consultation-based method is equal to SCORE and an extensive laboratory-based method in predicting risk of future cardiovascular disease.
(2009) In European Journal of Cardiovascular Prevention & Rehabilitation 16. p.536-540- Abstract
- BACKGROUND: As cardiovascular disease (CVD) is one of the most common causes of mortality worldwide, much interest has been focused on reliable methods to predict cardiovascular risk. DESIGN: A cross-sectional, population-based screening study with 17-year follow-up in Southern Sweden. METHODS: We compared a non-laboratory, consultation-based risk assessment method comprising age, sex, present smoking, prevalent diabetes or hypertension at baseline, blood pressure (systolic >/=140 or diastolic >/=90), waist/height ratio and family history of CVD to Systemic COronary Risk Evaluation (SCORE) and a third model including several laboratory analyses, respectively, in predicting CVD risk. The study included clinical baseline data on 689... (More)
- BACKGROUND: As cardiovascular disease (CVD) is one of the most common causes of mortality worldwide, much interest has been focused on reliable methods to predict cardiovascular risk. DESIGN: A cross-sectional, population-based screening study with 17-year follow-up in Southern Sweden. METHODS: We compared a non-laboratory, consultation-based risk assessment method comprising age, sex, present smoking, prevalent diabetes or hypertension at baseline, blood pressure (systolic >/=140 or diastolic >/=90), waist/height ratio and family history of CVD to Systemic COronary Risk Evaluation (SCORE) and a third model including several laboratory analyses, respectively, in predicting CVD risk. The study included clinical baseline data on 689 participants aged 40-59 years without CVD. Blood samples were analyzed for blood glucose, serum lipids, insulin, insulin-like growth factor-I, insulin-like growth factor binding protein-1, C-reactive protein, asymmetric dimethyl arginine and symmetric dimethyl arginine. During 17 years, the incidence of total CVD (first event) and death was registered. RESULTS: A non-laboratory-based risk assessment model, including variables easily obtained during one consultation visit to a general practitioner, predicted cardiovascular events as accurately [hazard ratio (HR): 2.72; 95% confidence interval (CI): 2.18-3.39, P<0.001] as the established SCORE algorithm (HR: 2.73; 95% CI: 2.10-3.55, P<0.001), which requires laboratory testing. Furthermore, adding a combination of sophisticated laboratory measurements covering lipids, inflammation and endothelial dysfunction, did not confer any additional value to the prediction of CVD risk (HR: 2.72; 95% CI: 2.19-3.37, P<0.001). The c-statistics for the consultation model (0.794; 95% CI: 0.762-0.823) was not significantly different from SCORE (0.767; 95% CI: 0.733-0.798, P=0.12) or the extended model (0.806; 95% CI: 0.774-0.835, P=0.55). CONCLUSION: A risk algorithm based on non-laboratory data from a single primary care consultation predicted long-term cardiovascular risk as accurately as either SCORE or an elaborate laboratory-based method in a defined middle-aged population. (Less)
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https://lup.lub.lu.se/record/1392225
- author
- Petersson, Ulla LU ; Östgren, Carl Johan LU ; Brudin, Lars and Nilsson, Peter LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Cardiovascular Prevention & Rehabilitation
- volume
- 16
- pages
- 536 - 540
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000271456200003
- pmid:19357517
- scopus:72449183200
- ISSN
- 1741-8275
- DOI
- 10.1097/HJR.0b013e32832b1833
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Family Medicine (013241010), Internal Medicine Research Unit (013242520), Psychiatry/Primary Care/Public Health (013240500)
- id
- 780ed7ed-740c-4d37-8ac0-560fc7767ebb (old id 1392225)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19357517?dopt=Abstract
- date added to LUP
- 2016-04-04 07:07:54
- date last changed
- 2022-04-07 22:19:32
@article{780ed7ed-740c-4d37-8ac0-560fc7767ebb,
abstract = {{BACKGROUND: As cardiovascular disease (CVD) is one of the most common causes of mortality worldwide, much interest has been focused on reliable methods to predict cardiovascular risk. DESIGN: A cross-sectional, population-based screening study with 17-year follow-up in Southern Sweden. METHODS: We compared a non-laboratory, consultation-based risk assessment method comprising age, sex, present smoking, prevalent diabetes or hypertension at baseline, blood pressure (systolic >/=140 or diastolic >/=90), waist/height ratio and family history of CVD to Systemic COronary Risk Evaluation (SCORE) and a third model including several laboratory analyses, respectively, in predicting CVD risk. The study included clinical baseline data on 689 participants aged 40-59 years without CVD. Blood samples were analyzed for blood glucose, serum lipids, insulin, insulin-like growth factor-I, insulin-like growth factor binding protein-1, C-reactive protein, asymmetric dimethyl arginine and symmetric dimethyl arginine. During 17 years, the incidence of total CVD (first event) and death was registered. RESULTS: A non-laboratory-based risk assessment model, including variables easily obtained during one consultation visit to a general practitioner, predicted cardiovascular events as accurately [hazard ratio (HR): 2.72; 95% confidence interval (CI): 2.18-3.39, P<0.001] as the established SCORE algorithm (HR: 2.73; 95% CI: 2.10-3.55, P<0.001), which requires laboratory testing. Furthermore, adding a combination of sophisticated laboratory measurements covering lipids, inflammation and endothelial dysfunction, did not confer any additional value to the prediction of CVD risk (HR: 2.72; 95% CI: 2.19-3.37, P<0.001). The c-statistics for the consultation model (0.794; 95% CI: 0.762-0.823) was not significantly different from SCORE (0.767; 95% CI: 0.733-0.798, P=0.12) or the extended model (0.806; 95% CI: 0.774-0.835, P=0.55). CONCLUSION: A risk algorithm based on non-laboratory data from a single primary care consultation predicted long-term cardiovascular risk as accurately as either SCORE or an elaborate laboratory-based method in a defined middle-aged population.}},
author = {{Petersson, Ulla and Östgren, Carl Johan and Brudin, Lars and Nilsson, Peter}},
issn = {{1741-8275}},
language = {{eng}},
pages = {{536--540}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{European Journal of Cardiovascular Prevention & Rehabilitation}},
title = {{A consultation-based method is equal to SCORE and an extensive laboratory-based method in predicting risk of future cardiovascular disease.}},
url = {{http://dx.doi.org/10.1097/HJR.0b013e32832b1833}},
doi = {{10.1097/HJR.0b013e32832b1833}},
volume = {{16}},
year = {{2009}},
}