Bcl-2 but not FOXP1, is an adverse risk factor in immunochemotherapy-treated non-germinal center diffuse large B-cell lymphomas
(2009) In European Journal of Haematology 82(5). p.364-372- Abstract
- Non-germinal center (non-GC) phenotype, high level expression of the transcription factor forkhead box protein P1 (FOXP1) and anti-apoptotic protein Bcl-2 have been identified as unfavorable prognostic factors for diffuse large B-cell lymphoma (DLBCL) patients treated with chemotherapy. Our aim was to re-evaluate the prognostic impact of these biologic factors on the survival of the patients treated with immunochemotherapy. Expression of Bcl-2 and FOXP1, and cell of origin based on the Hans algorithm were determined immunohistochemically from samples of 117 de novo DLBCL patients treated with R-CHOP and R-CHOEP regimens, and correlated with clinical data. Consistent with our previous studies, no significant difference in 2-yr survival... (More)
- Non-germinal center (non-GC) phenotype, high level expression of the transcription factor forkhead box protein P1 (FOXP1) and anti-apoptotic protein Bcl-2 have been identified as unfavorable prognostic factors for diffuse large B-cell lymphoma (DLBCL) patients treated with chemotherapy. Our aim was to re-evaluate the prognostic impact of these biologic factors on the survival of the patients treated with immunochemotherapy. Expression of Bcl-2 and FOXP1, and cell of origin based on the Hans algorithm were determined immunohistochemically from samples of 117 de novo DLBCL patients treated with R-CHOP and R-CHOEP regimens, and correlated with clinical data. Consistent with our previous studies, no significant difference in 2-yr survival rates between the GC- and non-GC phenotypes was found. Both FOXP1 and Bcl-2 expression were associated with the non-GC phenotype. For all patients, no prognostic impact of FOXP1 positivity on survival was observed. However, Bcl-2 negative patients had a better survival as compared to Bcl-2 positive patients [failure free survival (FFS) 97% vs. 71%, P = 0.001 and overall survival (OS) 97% vs. 82%, P = 0.034]. When Bcl-2 related survival was analyzed in the GC- and non-GC subgroups, a significant prognostic effect of Bcl-2 on FFS was seen only in the non-GC group of patients (positive 65% vs. negative 100%, P = 0.011). A trend for the difference in OS was also observed (positive 84% vs. negative 100%, P = 0.082). The data demonstrate that expression of Bcl-2 and FOXP1 is associated with the non-GC phenotype, but only Bcl-2 expression continues to be of prognostic significance in DLBCL patients treated with immunochemotherapy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1400664
- author
- Nyman, Heidi ; Jerkeman, Mats LU ; Karjalainen-Lindsberg, Marja-Liisa ; Banham, Alison H. ; Enblad, Gunilla and Leppa, Sirpa
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bcl-2, diffuse large B-cell lymphoma, forkhead box protein P1, non-germinal center, prognosis
- in
- European Journal of Haematology
- volume
- 82
- issue
- 5
- pages
- 364 - 372
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000264956300005
- scopus:64249173340
- pmid:19141121
- ISSN
- 1600-0609
- DOI
- 10.1111/j.1600-0609.2009.01222.x
- language
- English
- LU publication?
- yes
- id
- c70dee35-76b7-454c-869f-bfd0276718a4 (old id 1400664)
- date added to LUP
- 2016-04-01 11:52:58
- date last changed
- 2022-03-28 17:06:22
@article{c70dee35-76b7-454c-869f-bfd0276718a4, abstract = {{Non-germinal center (non-GC) phenotype, high level expression of the transcription factor forkhead box protein P1 (FOXP1) and anti-apoptotic protein Bcl-2 have been identified as unfavorable prognostic factors for diffuse large B-cell lymphoma (DLBCL) patients treated with chemotherapy. Our aim was to re-evaluate the prognostic impact of these biologic factors on the survival of the patients treated with immunochemotherapy. Expression of Bcl-2 and FOXP1, and cell of origin based on the Hans algorithm were determined immunohistochemically from samples of 117 de novo DLBCL patients treated with R-CHOP and R-CHOEP regimens, and correlated with clinical data. Consistent with our previous studies, no significant difference in 2-yr survival rates between the GC- and non-GC phenotypes was found. Both FOXP1 and Bcl-2 expression were associated with the non-GC phenotype. For all patients, no prognostic impact of FOXP1 positivity on survival was observed. However, Bcl-2 negative patients had a better survival as compared to Bcl-2 positive patients [failure free survival (FFS) 97% vs. 71%, P = 0.001 and overall survival (OS) 97% vs. 82%, P = 0.034]. When Bcl-2 related survival was analyzed in the GC- and non-GC subgroups, a significant prognostic effect of Bcl-2 on FFS was seen only in the non-GC group of patients (positive 65% vs. negative 100%, P = 0.011). A trend for the difference in OS was also observed (positive 84% vs. negative 100%, P = 0.082). The data demonstrate that expression of Bcl-2 and FOXP1 is associated with the non-GC phenotype, but only Bcl-2 expression continues to be of prognostic significance in DLBCL patients treated with immunochemotherapy.}}, author = {{Nyman, Heidi and Jerkeman, Mats and Karjalainen-Lindsberg, Marja-Liisa and Banham, Alison H. and Enblad, Gunilla and Leppa, Sirpa}}, issn = {{1600-0609}}, keywords = {{Bcl-2; diffuse large B-cell lymphoma; forkhead box protein P1; non-germinal center; prognosis}}, language = {{eng}}, number = {{5}}, pages = {{364--372}}, publisher = {{Wiley-Blackwell}}, series = {{European Journal of Haematology}}, title = {{Bcl-2 but not FOXP1, is an adverse risk factor in immunochemotherapy-treated non-germinal center diffuse large B-cell lymphomas}}, url = {{http://dx.doi.org/10.1111/j.1600-0609.2009.01222.x}}, doi = {{10.1111/j.1600-0609.2009.01222.x}}, volume = {{82}}, year = {{2009}}, }