Inhibition of inducible TNF-alpha expression by oxaspirodion, a novel spiro-compound from the ascomycete Chaetomium subspirale
(2004) In Biological Chemistry 385(9). p.829-834- Abstract
- In a search for compounds inhibiting the inducible TNF-alpha promoter activity in T cells, a new spirocompound, designated oxaspirodion, was isolated from fermentations of the ascomycete Chaetomium subspirale. Oxaspirodion inhibited TNF-alpha promoterdriven luciferase reporter gene expression with an IC50 value of 2.5 mug/ml (10 muM) in TPA/ionomycinstimulated Jurkat T cells. Studies on the mode of action of the compound revealed that the inhibition of the TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the ERK1/2 kinases. In addition, oxaspirodion inhibited the activation of the transcription factor NF-kappaB, which is involved in the inducible expression of many proinflammatory genes.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/141191
- author
- Rether, J ; Erkel, G ; Anke, T and Sterner, Olov LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biological Chemistry
- volume
- 385
- issue
- 9
- pages
- 829 - 834
- publisher
- De Gruyter
- external identifiers
-
- wos:000223772900009
- pmid:15493878
- scopus:5044221540
- ISSN
- 1437-4315
- DOI
- 10.1515/BC.2004.108
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- eba00987-69cb-435d-a79f-4681b91fe9d5 (old id 141191)
- date added to LUP
- 2016-04-01 12:34:37
- date last changed
- 2022-01-27 07:00:41
@article{eba00987-69cb-435d-a79f-4681b91fe9d5, abstract = {{In a search for compounds inhibiting the inducible TNF-alpha promoter activity in T cells, a new spirocompound, designated oxaspirodion, was isolated from fermentations of the ascomycete Chaetomium subspirale. Oxaspirodion inhibited TNF-alpha promoterdriven luciferase reporter gene expression with an IC50 value of 2.5 mug/ml (10 muM) in TPA/ionomycinstimulated Jurkat T cells. Studies on the mode of action of the compound revealed that the inhibition of the TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the ERK1/2 kinases. In addition, oxaspirodion inhibited the activation of the transcription factor NF-kappaB, which is involved in the inducible expression of many proinflammatory genes.}}, author = {{Rether, J and Erkel, G and Anke, T and Sterner, Olov}}, issn = {{1437-4315}}, language = {{eng}}, number = {{9}}, pages = {{829--834}}, publisher = {{De Gruyter}}, series = {{Biological Chemistry}}, title = {{Inhibition of inducible TNF-alpha expression by oxaspirodion, a novel spiro-compound from the ascomycete Chaetomium subspirale}}, url = {{http://dx.doi.org/10.1515/BC.2004.108}}, doi = {{10.1515/BC.2004.108}}, volume = {{385}}, year = {{2004}}, }