Functional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin
(2004) In Science 305(5683). p.519-522- Abstract
- Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group... (More)
- Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O–dominant human populations. (Less)
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https://lup.lub.lu.se/record/141467
- author
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Science
- volume
- 305
- issue
- 5683
- pages
- 519 - 522
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- pmid:15273394
- wos:000222828900040
- scopus:3242748894
- ISSN
- 1095-9203
- DOI
- 10.1126/science.1098801
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Department of Experimental Medical Science (013210000), Division of Microbiology, Immunology and Glycobiology - MIG (013025200)
- id
- 60462915-6287-463f-9245-e23cd0a07095 (old id 141467)
- date added to LUP
- 2016-04-01 15:30:32
- date last changed
- 2022-04-22 08:03:48
@article{60462915-6287-463f-9245-e23cd0a07095, abstract = {{Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O–dominant human populations.}}, author = {{Aspholm-Hurtig, Marina and Dailide, Giedrius and Lahmann, Martina and Kalia, Awdhesh and Ilver, Dag and Roche, Niamh and Vikström, Susanne and Sjöström, Rolf and Lindén, Sara and Bäckström, Anna and Lundberg, Carina and Arnqvist, Anna and Mahdavi, Jafar and Nilsson, Ulf and Velapatiño, Billie and Gilman, Robert H and Gerhard, Markus and Alarcon, Teresa and López-Brea, Manuel and Nakazawa, Teruko and Fox, James G and Correa, Pelayo and Dominguez-Bello, Maria Gloria and Perez-Perez, Guillermo I and Blaser, Martin J and Normark, Staffan and Carlstedt, Ingemar and Oscarson, Stefan and Teneberg, Susann and Berg, Douglas E and Borén, Thomas}}, issn = {{1095-9203}}, language = {{eng}}, number = {{5683}}, pages = {{519--522}}, publisher = {{American Association for the Advancement of Science (AAAS)}}, series = {{Science}}, title = {{Functional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin}}, url = {{http://dx.doi.org/10.1126/science.1098801}}, doi = {{10.1126/science.1098801}}, volume = {{305}}, year = {{2004}}, }