High-throughput proteomics using antibody microarrays
(2004) In Espert Review of Proteomics 1(3). p.355-364- Abstract
- Antibody-based microarrays are a novel technology that hold great promise in proteomics. Microarrays can be printed with thousands of recombinant antibodies carrying the desired specificities, the biologic sample (e.g., an entire proteome) and any specifically bound analytes detected. The microarray patterns that are generated can then be converted into proteomic maps, or molecular fingerprints, revealing the composition of the proteome. Using this tool, global proteome analysis and protein expression profiling will thus provide new opportunities for biomarker discovery, drug target identification and disease diagnostics, as well as providing insights into disease biology. Intense work is currently underway to develop this novel technology... (More)
- Antibody-based microarrays are a novel technology that hold great promise in proteomics. Microarrays can be printed with thousands of recombinant antibodies carrying the desired specificities, the biologic sample (e.g., an entire proteome) and any specifically bound analytes detected. The microarray patterns that are generated can then be converted into proteomic maps, or molecular fingerprints, revealing the composition of the proteome. Using this tool, global proteome analysis and protein expression profiling will thus provide new opportunities for biomarker discovery, drug target identification and disease diagnostics, as well as providing insights into disease biology. Intense work is currently underway to develop this novel technology platform into the high-throughput proteomic tool required by the research community. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/141773
- author
- Wingren, Christer LU and Borrebaeck, Carl LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Espert Review of Proteomics
- volume
- 1
- issue
- 3
- pages
- 355 - 364
- publisher
- Future Drugs Ltd
- external identifiers
-
- wos:000230114400016
- pmid:15966831
- scopus:19444381184
- ISSN
- 1744-8387
- DOI
- 10.1586/14789450.1.3.355
- language
- English
- LU publication?
- yes
- id
- b9b8bba7-714b-4165-bdf1-3337acff9937 (old id 141773)
- date added to LUP
- 2016-04-01 11:45:53
- date last changed
- 2022-01-26 17:51:13
@article{b9b8bba7-714b-4165-bdf1-3337acff9937,
abstract = {{Antibody-based microarrays are a novel technology that hold great promise in proteomics. Microarrays can be printed with thousands of recombinant antibodies carrying the desired specificities, the biologic sample (e.g., an entire proteome) and any specifically bound analytes detected. The microarray patterns that are generated can then be converted into proteomic maps, or molecular fingerprints, revealing the composition of the proteome. Using this tool, global proteome analysis and protein expression profiling will thus provide new opportunities for biomarker discovery, drug target identification and disease diagnostics, as well as providing insights into disease biology. Intense work is currently underway to develop this novel technology platform into the high-throughput proteomic tool required by the research community.}},
author = {{Wingren, Christer and Borrebaeck, Carl}},
issn = {{1744-8387}},
language = {{eng}},
number = {{3}},
pages = {{355--364}},
publisher = {{Future Drugs Ltd}},
series = {{Espert Review of Proteomics}},
title = {{High-throughput proteomics using antibody microarrays}},
url = {{http://dx.doi.org/10.1586/14789450.1.3.355}},
doi = {{10.1586/14789450.1.3.355}},
volume = {{1}},
year = {{2004}},
}