Heparan sulphate proteoglycans: the sweet side of development.
(2005) In Nature Reviews Molecular Cell Biology 6(7). p.530-541- Abstract
- Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/143007
- author
- Häcker, Udo LU ; Nybakken, Kent and Perrimon, Norbert
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Glycosaminoglycans: biosynthesis, Gene Expression Regulation, Animals, N.I.H., U.S. Gov't, P.H.S., Signal Transduction, Non-U.S. Gov't, Research Support, Extramural, Heparan Sulfate Proteoglycan: genetics, Heparan Sulfate Proteoglycan: physiology, Humans, Mutation
- in
- Nature Reviews Molecular Cell Biology
- volume
- 6
- issue
- 7
- pages
- 530 - 541
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000230245700010
- pmid:16072037
- scopus:21744450786
- ISSN
- 1471-0072
- DOI
- 10.1038/nrm1681
- language
- English
- LU publication?
- yes
- id
- 6df48a69-7216-4a48-910e-c123b3a6bfcd (old id 143007)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16072037&dopt=Abstract
- date added to LUP
- 2016-04-01 16:42:00
- date last changed
- 2024-09-13 20:41:51
@article{6df48a69-7216-4a48-910e-c123b3a6bfcd, abstract = {{Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development.}}, author = {{Häcker, Udo and Nybakken, Kent and Perrimon, Norbert}}, issn = {{1471-0072}}, keywords = {{Glycosaminoglycans: biosynthesis; Gene Expression Regulation; Animals; N.I.H.; U.S. Gov't; P.H.S.; Signal Transduction; Non-U.S. Gov't; Research Support; Extramural; Heparan Sulfate Proteoglycan: genetics; Heparan Sulfate Proteoglycan: physiology; Humans; Mutation}}, language = {{eng}}, number = {{7}}, pages = {{530--541}}, publisher = {{Nature Publishing Group}}, series = {{Nature Reviews Molecular Cell Biology}}, title = {{Heparan sulphate proteoglycans: the sweet side of development.}}, url = {{http://dx.doi.org/10.1038/nrm1681}}, doi = {{10.1038/nrm1681}}, volume = {{6}}, year = {{2005}}, }