The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis.
(2009) In Arthritis Research and Therapy 11(3).- Abstract
- ABSTRACT: For a long time, genetic studies of complex diseases were most successfully conducted in animal models. However, the field of genetics is now rapidly evolving, and human genetics has also started to produce strong candidate genes for complex diseases. This raises the question of how to continue gene-finding attempts in animals and how to use animal models to enhance our understanding of gene function. In this review we summarize the uses and advantages of animal studies in identification of disease susceptibility genes, focusing on rheumatoid arthritis. We are convinced that animal genetics will remain a valuable tool for the identification and investigation of pathways that lead to disease, well into the future.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1434624
- author
- Ahlqvist, Emma LU ; Hultqvist, Malin LU and Holmdahl, Rikard LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Arthritis Research and Therapy
- volume
- 11
- issue
- 3
- article number
- 226
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000269019300012
- pmid:19490601
- scopus:65949083562
- pmid:19490601
- ISSN
- 1478-6362
- DOI
- 10.1186/ar2600
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
- id
- 06a3068c-5b3c-41e5-9a9b-1ac765bab715 (old id 1434624)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19490601?dopt=Abstract
- date added to LUP
- 2016-04-04 07:45:47
- date last changed
- 2022-03-15 07:19:47
@article{06a3068c-5b3c-41e5-9a9b-1ac765bab715, abstract = {{ABSTRACT: For a long time, genetic studies of complex diseases were most successfully conducted in animal models. However, the field of genetics is now rapidly evolving, and human genetics has also started to produce strong candidate genes for complex diseases. This raises the question of how to continue gene-finding attempts in animals and how to use animal models to enhance our understanding of gene function. In this review we summarize the uses and advantages of animal studies in identification of disease susceptibility genes, focusing on rheumatoid arthritis. We are convinced that animal genetics will remain a valuable tool for the identification and investigation of pathways that lead to disease, well into the future.}}, author = {{Ahlqvist, Emma and Hultqvist, Malin and Holmdahl, Rikard}}, issn = {{1478-6362}}, language = {{eng}}, number = {{3}}, publisher = {{BioMed Central (BMC)}}, series = {{Arthritis Research and Therapy}}, title = {{The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis.}}, url = {{https://lup.lub.lu.se/search/files/5151575/1445700.pdf}}, doi = {{10.1186/ar2600}}, volume = {{11}}, year = {{2009}}, }