Autism spectrum disorder and underlying brain mechanism in the oculoauriculovertebral spectrum
Johansson, Maria ; Billstedt, Eva ; Danielsson, Susanna ; Strömland, Kerstin ; Miller, Marilyn ; Granström, Gösta ; Flodmark, Olof ; Råstam, Maria LU
and Gillberg, Christopher
(2007)
In Developmental Medicine & Child Neurology
49(4).
p.8-280
- Abstract
- As part of a multidisciplinary study, the rate of autism spectrum disorder (ASD), learning disability (LD), and brain abnormalities was examined in 20 participants (12 males, 8 females; age range 8mo-17y, mean age 8y 1mo) diagnosed as falling within the oculoauriculovertebral spectrum (OAV). A neuropsychiatric examination was performed, including standardized autism diagnostic interviews. Two individuals met diagnostic criteria for autism, one for autistic-like condition, and five for autistic traits. Four patients had mild LD, three severe LD, two profound LD, and two borderline intellectual functioning. Neuroimaging indicated cerebral abnormalities in more than half of the patients. Abnormalities of white/grey matter were found in more... (More)
- As part of a multidisciplinary study, the rate of autism spectrum disorder (ASD), learning disability (LD), and brain abnormalities was examined in 20 participants (12 males, 8 females; age range 8mo-17y, mean age 8y 1mo) diagnosed as falling within the oculoauriculovertebral spectrum (OAV). A neuropsychiatric examination was performed, including standardized autism diagnostic interviews. Two individuals met diagnostic criteria for autism, one for autistic-like condition, and five for autistic traits. Four patients had mild LD, three severe LD, two profound LD, and two borderline intellectual functioning. Neuroimaging indicated cerebral abnormalities in more than half of the patients. Abnormalities of white/grey matter were found in more than half of examined individuals; enlargement of ventricles in more than a third. Results indicate that at least a subgroup of ASD may be associated with errors in early embryonic brain development. Awareness of the coexistence of OAV/ASD is important in habilitation care of individuals with OAV. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1440414
- author
- Johansson, Maria
; Billstedt, Eva
; Danielsson, Susanna
; Strömland, Kerstin
; Miller, Marilyn
; Granström, Gösta
; Flodmark, Olof
; Råstam, Maria
LU
and Gillberg, Christopher
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- AdolescentAutistic Disorder/diagnosisAutistic Disorder/physiopathology*Autistic Disorder/rehabilitationBrain/abnormalities*Brain/pathologyBrain/physiopathologyChildChild, PreschoolDiagnostic and Statistical Manual of Mental DisordersElectroencephalographyFemaleGoldenhar Syndrome/diagnosisGoldenhar Syndrome/physiopathology*Goldenhar Syndrome/rehabilitationHumansInfantInfant, NewbornMagnetic Resonance ImagingMaleMental Retardation/diagnosisMental Retardation/physiopathologyNeuropsychological TestsPatient Care TeamPregnancyProspective StudiesRisk FactorsTomography, X-Ray Computed
- in
- Developmental Medicine & Child Neurology
- volume
- 49
- issue
- 4
- pages
- 8 - 280
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:33947573485
- pmid:17376139
- ISSN
- 0012-1622
- DOI
- 10.1111/j.1469-8749.2007.00280.x
- language
- English
- LU publication?
- no
- id
- f57b6d86-137f-4152-a08f-7c114de2cf3e (old id 1440414)
- alternative location
- http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8749.2007.00280.x/abstract
- date added to LUP
- 2016-04-01 12:27:04
- date last changed
- 2022-01-27 03:55:09
@article{f57b6d86-137f-4152-a08f-7c114de2cf3e,
abstract = {{As part of a multidisciplinary study, the rate of autism spectrum disorder (ASD), learning disability (LD), and brain abnormalities was examined in 20 participants (12 males, 8 females; age range 8mo-17y, mean age 8y 1mo) diagnosed as falling within the oculoauriculovertebral spectrum (OAV). A neuropsychiatric examination was performed, including standardized autism diagnostic interviews. Two individuals met diagnostic criteria for autism, one for autistic-like condition, and five for autistic traits. Four patients had mild LD, three severe LD, two profound LD, and two borderline intellectual functioning. Neuroimaging indicated cerebral abnormalities in more than half of the patients. Abnormalities of white/grey matter were found in more than half of examined individuals; enlargement of ventricles in more than a third. Results indicate that at least a subgroup of ASD may be associated with errors in early embryonic brain development. Awareness of the coexistence of OAV/ASD is important in habilitation care of individuals with OAV.}},
author = {{Johansson, Maria and Billstedt, Eva and Danielsson, Susanna and Strömland, Kerstin and Miller, Marilyn and Granström, Gösta and Flodmark, Olof and Råstam, Maria and Gillberg, Christopher}},
issn = {{0012-1622}},
keywords = {{AdolescentAutistic Disorder/diagnosisAutistic Disorder/physiopathology*Autistic Disorder/rehabilitationBrain/abnormalities*Brain/pathologyBrain/physiopathologyChildChild; PreschoolDiagnostic and Statistical Manual of Mental DisordersElectroencephalographyFemaleGoldenhar Syndrome/diagnosisGoldenhar Syndrome/physiopathology*Goldenhar Syndrome/rehabilitationHumansInfantInfant; NewbornMagnetic Resonance ImagingMaleMental Retardation/diagnosisMental Retardation/physiopathologyNeuropsychological TestsPatient Care TeamPregnancyProspective StudiesRisk FactorsTomography; X-Ray Computed}},
language = {{eng}},
number = {{4}},
pages = {{8--280}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Developmental Medicine & Child Neurology}},
title = {{Autism spectrum disorder and underlying brain mechanism in the oculoauriculovertebral spectrum}},
url = {{http://dx.doi.org/10.1111/j.1469-8749.2007.00280.x}},
doi = {{10.1111/j.1469-8749.2007.00280.x}},
volume = {{49}},
year = {{2007}},
}